Sec22b is a negative regulator of phagocytosis in macrophages.
Fukushima, Japan. In Mol Biol Cell, 2009
The R-SNARE motif, a selective domain for forming a SNARE complex with syntaxin18 and/or D12, was responsible for the inhibition of phagocytosis. Sec22b is a negative regulator of phagocytosis in macrophages by regulating free syntaxin 18 and/or D12.
Differential use of endoplasmic reticulum membrane for phagocytosis in J774 macrophages.
New York City, United States. In Proc Natl Acad Sci U S A, 2005
Here we report that direct ER-plasma membrane fusion during phagocytosis requires the ER resident soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) protein ERS24/Sec22b and that J774-macrophages react toward the challenge of large (3.0-microm) but not small (0.8-microm) particles by triggering this fusion mechanism, allowing them to access the most abundant endogenous membrane source in the cell, the ER.