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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Signal peptide, CUB domain, EGF-like 3

SCUBE3, hSCUBE3
Top mentioned proteins: Epidermal Growth Factor, SCUBE2, CAN, CIs, CD45
Papers on SCUBE3
Disruption of Scube2 Impairs Endochondral Bone Formation.
New
Yang et al., Taipei, Taiwan. In J Bone Miner Res, Jul 2015
In this study, we first showed that as compared with SCUBE1 or SCUBE3, SCUBE2 is the most potent modulator of IHH signaling in vitro.
SCUBE3 (signal peptide-CUB-EGF domain-containing protein 3) modulates fibroblast growth factor signaling during fast muscle development.
Yang et al., Taipei, Taiwan. In J Biol Chem, 2014
SCUBE3 (signal peptide CUB-EGF-like domain-containing protein 3) belongs to a newly identified secreted and cell membrane-associated SCUBE family, which is evolutionarily conserved in vertebrates.
[Role of SCUBE3 in promoting osteosarcoma cell growth and its association with prognosis].
Shen et al., Guangzhou, China. In Nan Fang Yi Ke Da Xue Xue Bao, 2014
OBJECTIVE: To detect the expression of SCUBE3 in human osteosarcoma cell lines and surgical specimens of osteosarcomas and investigate its association with the patients' prognosis.
SCUBE3 overexpression predicts poor prognosis in non-small cell lung cancer.
Deng et al., Shanghai, China. In Biosci Trends, 2013
Signal peptide-CUB-EGF-like domain-containing protein 3 (SCUBE3) is highly expressed in invasive lung cancers.
Genome-wide association studies identify the loci for 5 exterior traits in a Large White × Minzhu pig population.
Wang et al., Beijing, China. In Plos One, 2013
Annotations from pig reference genome suggested six genes (GRM4, HMGA1, NUDT3, RPS10, SPDEF and PACSIN1) in block 1 (495 kb), and one gene (SCUBE3) in block 3 (124 kb).
Scube regulates synovial angiogenesis-related signaling.
Jiang et al., Chengdu, China. In Med Hypotheses, 2013
Scube3 functions as an endogenous TGFβ receptor ligand, increasing Smad2/3 phosphorylation, and thus upregulates target genes involved in angiogenesis.
The role of Vitamin D level and related single nucleotide polymorphisms in Crohn's disease.
Ferguson et al., São Paulo, Brazil. In Nutrients, 2013
Two variants: rs731236[A] (VDR) and rs732594[A] (SCUBE3) showed a significant association with serum Vit D levels in CD patients.
SCUBE3 regulation of early lung cancer angiogenesis and metastatic progression.
Chang et al., Taipei, Taiwan. In Clin Exp Metastasis, 2013
Signal peptide-CUB-EGF-like domain-containing protein 3 (SCUBE3) is strongly expressed in extremely invasive lung carcinoma.
Localization and characterization of a novel secreted protein, SCUBE2, in the development and progression of atherosclerosis.
Hirata et al., Kōbe, Japan. In Kobe J Med Sci, 2012
Two members of the SCUBE family, SCUBE1 and SCUBE3 are reported to play a role in cardiovascular diseases.
Scube3 is expressed in multiple tissues during development but is dispensable for embryonic survival in the mouse.
Cobourne et al., London, United Kingdom. In Plos One, 2012
In order to further investigate the role of Scube genes during development, we have generated mice with targeted inactivation of Scube3.
Genome-wide association study of porcine hematological parameters in a Large White × Minzhu F2 resource population.
Zhang et al., Beijing, China. In Int J Biol Sci, 2011
In current research, a total of seven significant SNPs were found within six candidate genes SCUBE3, KDR, TDO, IGFBP7, ADAMTS3 and AFP.
SCUBE3 is an endogenous TGF-β receptor ligand and regulates the epithelial-mesenchymal transition in lung cancer.
GeneRIF
Yang et al., Taipei, Taiwan. In Oncogene, 2011
in lung cancer cells, SCUBE3 could serve as an endogenous autocrine and paracrine ligand of TGF-beta type II receptor, which could regulate TGF-beta receptor signaling and modulate EMT and cancer progression
Genome-wide methylation analysis identifies epigenetically inactivated candidate tumour suppressor genes in renal cell carcinoma.
Maher et al., Birmingham, United Kingdom. In Oncogene, 2011
MeDIP analysis on 9 RCC tumours and 3 non-malignant normal kidney tissue samples was performed, and an initial shortlist of 56 candidate genes that were methylated by array analysis was further investigated; 9 genes were confirmed to show frequent promoter region methylation in primary RCC tumour samples (KLHL35 (39%), QPCT (19%), SCUBE3 (19%), ZSCAN18 (32%), CCDC8 (35%), FBN2 (34%), ATP5G2 (36%), PCDH8 (58%) and CORO6 (22%)).
Characterization of a mouse Scube3 reporter line.
Cobourne et al., London, United Kingdom. In Genesis, 2010
We describe a Scube3(tm1Dge/H) targeted allele, which replaces the entire coding region for Exons 2 and 3 with a neomycin-lacZ selectable marker cassette predicted to delete the first two EGF-like domains of the transcribed protein.
Transgenic overexpression of the secreted, extracellular EGF-CUB domain-containing protein SCUBE3 induces cardiac hypertrophy in mice.
Yang et al., Taipei, Taiwan. In Cardiovasc Res, 2007
OBJECTIVE: The aim of this study was to investigate in a transgenic animal model the cardiac expression and function of a novel extracellular protein SCUBE3 [signal peptide-CUB (complement proteins C1r/C1s, Uegf, and Bmp1)-EGF (epidermal growth factor)-like domain-containing protein 3].
A novel secreted, cell-surface glycoprotein containing multiple epidermal growth factor-like repeats and one CUB domain is highly expressed in primary osteoblasts and bones.
GeneRIF
Yang et al., Taipei, Taiwan. In J Biol Chem, 2004
may act locally and/or distantly through a proteolytic mechanism, and may play an important role in bone cell biology
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