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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Signal peptide, CUB domain, EGF-like 2

SCUBE2, U-shaped somites, CEGP1, CEGF1
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Top mentioned proteins: Epidermal Growth Factor, CAN, CD45, Shh, CagA
Papers on SCUBE2
Disruption of Scube2 Impairs Endochondral Bone Formation.
New
Yang et al., Taipei, Taiwan. In J Bone Miner Res, Jul 2015
Signal peptide-CUB-EGF domain-containing protein 2 (SCUBE2) belongs to a secreted and membrane-tethered multidomain SCUBE protein family composed of three members found in vertebrates and mammals.
Decreased expression of SCUBE2 is associated with progression and prognosis in colorectal cancer.
New
Wang et al., China. In Oncol Rep, Apr 2015
Signal peptide-CUB-epidermal growth factor-like domain-containing protein 2 (SCUBE2), a member of the SCUBE protein family, is a secreted and membrane-associated multi-domain glycoprotein.
Additive effect of the AZGP1, PIP, S100A8 and UBE2C molecular biomarkers improves outcome prediction in breast carcinoma.
Helou et al., Göteborg, Sweden. In Int J Cancer, 2014
In the external gene expression dataset, six of the 13 genes (AZGP1, NME5, S100A8, SCUBE2, STC2 and UBE2C) retained their prognostic potential and were significantly associated with disease-free survival (p < 0.001).
Tumor suppressor SCUBE2 inhibits breast-cancer cell migration and invasion through the reversal of epithelial-mesenchymal transition.
Yang et al., Taipei, Taiwan. In J Cell Sci, 2014
Signal peptide-CUB-EGF domain-containing protein 2 (SCUBE2) belongs to a secreted and membrane-associated multi-domain SCUBE protein family.
Expression of SCUBE2 gene declines in high grade endometrial cancer and associates with expression of steroid hormone receptors and tumor suppressor PTEN.
Treeck et al., Regensburg, Germany. In Gynecol Endocrinol, 2013
SCUBE2 (Signal peptide-CUB-epidermal growth factor-like domain-containing 2) gene codes for a cell-surface glycoprotein.
Clinical relevance of breast cancer-related genes as potential biomarkers for oral squamous cell carcinoma.
Helou et al., Göteborg, Sweden. In Bmc Cancer, 2013
RESULTS: We found that CBX2, SCUBE2, and STK32B protein expression were associated with important clinicopathological features for OSCC (peritumoral inflammatory infiltration, metastatic spread to the cervical lymph nodes, and tumor size).
Genetic determinants of plasma β₂-glycoprotein I levels: a genome-wide association study in extended pedigrees from Spain.
Soria et al., Barcelona, Spain. In J Thromb Haemost, 2013
RESULTS: After correction for multiple testing, three SNPs located in/around two genes (ELF5 and SCUBE2) reached genome-wide significance.
Co-expression of genes with estrogen receptor-α and progesterone receptor in human breast carcinoma tissue.
Wittliff et al., In Horm Mol Biol Clin Investig, 2012
Coordinate expression of EVL, NAT1, TBC1D9, SCUBE2, RABEP1, SLC39A6, TCEAL1, FUT8, XBP1, PTP4A2 or GATA3 with either ESR1 or PGR was detected.
Localization and characterization of a novel secreted protein, SCUBE2, in the development and progression of atherosclerosis.
Hirata et al., Kōbe, Japan. In Kobe J Med Sci, 2012
The other member, SCUBE2 has been reported to mediate Hedgehog (Hh) protein signaling and is expressed in major blood vessels during mouse embryogenesis.
Interrogating differences in expression of targeted gene sets to predict breast cancer outcome.
Wittliff et al., Louisville, United States. In Bmc Cancer, 2012
RESULTS: Univariate analyses revealed over-expression of RABEP1, PGR, NAT1, PTP4A2, SLC39A6, ESR1, EVL, TBC1D9, FUT8, and SCUBE2 were all associated with reduced time to disease-related mortality (HR between 0.8 and 0.91, adjusted p < 0.05), while RABEP1, PGR, SLC39A6, and FUT8 were also associated with reduced recurrence times.
Scube activity is necessary for Hedgehog signal transduction in vivo.
GeneRIF
Currie et al., Australia. In Dev Biol, 2012
Data show that knocking down the function of all three scube genes scube1, scube2 and scube3 simultaneously phenocopies a complete loss of Hedgehog (HH) signal transduction in the embryo.
Scube/You activity mediates release of dually lipid-modified Hedgehog signal in soluble form.
GeneRIF
Beachy et al., Stanford, United States. In Genes Dev, 2012
The role of Scube/You proteins in Hh signaling in vivo is to facilitate the release and mobilization of Hh proteins for distant action.
Scube2 expression extends beyond the central nervous system during mouse development.
GeneRIF
Cobourne et al., London, United Kingdom. In J Mol Histol, 2011
Scube2 may play an important role during development of multiple regions in the embryo.
Domain and functional analysis of a novel breast tumor suppressor protein, SCUBE2.
GeneRIF
Yang et al., Taipei, Taiwan. In J Biol Chem, 2011
Domain and functional analysis of a novel breast tumor suppressor protein, SCUBE2.
Core fucosylation is required for midline patterning during zebrafish development.
Shur et al., Atlanta, United States. In Dev Dyn, 2010
Reduced FucT8 expression leads to mild cyclopia, small forebrains, U-shaped somites, among other midline patterning defects.
Clinical implications of gene dosage and gene expression patterns in diploid breast carcinoma.
Helou et al., Göteborg, Sweden. In Clin Cancer Res, 2010
In addition, more malignant tumors with normal gene dosage levels displayed a recurrent overexpression of UBE2C, S100A8, and CBX2, and downregulation of LOC389033, STC2, DNALI1, SCUBE2, NME5, SUSD3, SERPINA11, AZGP1, and PIP.
Isolation and characterization of a secreted, cell-surface glycoprotein SCUBE2 from humans.
GeneRIF
Yang et al., Taipei, Taiwan. In Biochem J, 2009
The full-length cDNA of human SCUBE2 was isolated and the role in the hedgehog signalling cascade, was studied.
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