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Scrapie responsive gene 1

Scrg1, scrapie responsive gene 1, scrapie responsive protein 1

Scrapie-responsive gene 1 is associated with neurodegenerative changes observed in transmissible spongiform encephalopathies. It may play a role in host response to prion-associated infections. The scrapie responsive protein 1 may be partly included in the membrane or secreted by the cells due to its hydrophobic N-terminus. [provided by RefSeq, Jul 2008] (from NCBI)

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Top mentioned proteins: Bax, OUT, LC3B, PrP, HMG2

Papers on Scrg1

Transcriptional profiling predicts overwhelming homology of Schwann cells, olfactory ensheathing cells, and Schwann cell-like glia.

Baumgärtner et al., Hannover, Germany. In Glia, 2014

Thereby AQP1 and SCRG1 were predicted to be the most powerful biomarkers distinguishing SCs from OECs/SG.

Novel SCRG1/BST1 axis regulates self-renewal, migration, and osteogenic differentiation potential in mesenchymal stem cells.

Chosa et al., Japan. In Sci Rep, 2013

Here, we identified the hMSC-secreted protein SCRG1 and its receptor BST1 as a positive regulator of self-renewal, migration, and osteogenic differentiation.

Autophagy and cell death of Purkinje cells overexpressing Doppel in Ngsk Prnp-deficient mice.

Bailly et al., Strasbourg, France. In Brain Pathol, 2010

In this study, Western blotting and immunohistofluorescence show that both before and during significant PC loss, the scrapie-responsive gene 1 (Scrg1)--potentially associated with autophagy--and the autophagic markers LC3B and p62 increased in the NP(0/0) PCs whereas RT-PCR shows stable mRNA expression, suggesting that the degradation of autophagic products is impaired in NP(0/0) PCs.

Doppel induces autophagic stress in prion protein-deficient Purkinje cells.

Bailly et al., Strasbourg, France. In Autophagy, 2009

These neurons display increased amounts of several autophagy-related molecules such as the scrapie-responsive gene one (Scrg1), LC3B-II and p62 without showing any changes in mRNA expression; in addition, autolysosomes accumulate in all neuronal compartments including axon terminals.

Comprehensive gene expression analysis in human periodontal ligaments of the mandibular third molars performing vertical movement and the maxillary second premolars with occlusal contact.

Suda, Tokyo, Japan. In Orthod Craniofac Res, 2008

The expression of CALB1 (encoding calbindin 1), CYP26A1 (encoding cytochrome P450, family 26, subfamily A, polypeptide 1), SPOCK3 (encoding testican-3), CCK (encoding cholecystokinin) and SCRG1 (encoding scrapie responsive protein 1) was more than 30-fold higher in PDLs of the third molars than the second premolars.

Genome scans and gene expression microarrays converge to identify gene regulatory loci relevant in schizophrenia.

Byerley et al., Irvine, United States. In Hum Genet, 2006

Three genes in the 4q33-35.1 haplotype region were also differentially expressed in schizophrenia in postmortem dorsolateral prefrontal cortex: AGA, HMGB2, and SCRG1.

A predominantly articular cartilage-associated gene, SCRG1, is induced by glucocorticoid and stimulates chondrogenesis in vitro.

Tuan et al., Bethesda, United States. In Osteoarthritis Cartilage, 2006

One of the genes that met our criteria was SCRG1.

SCRG1, a potential marker of autophagy in transmissible spongiform encephalopathies.

Dandoy-Dron et al., Villejuif, France. In Autophagy, 2006

The Scrg1 gene was initially discovered as one of the genes upregulated in transmissible spongiform encephalopathies (TSE).

Scrg1 is induced in TSE and brain injuries, and associated with autophagy.

GeneRIF

Dandoy-Dron et al., Villejuif, France. In Eur J Neurosci, 2005

Taken together, our results indicate that Scrg1 is associated with neurodegenerative processes in TSE, but is not directly linked to dysregulation of prion protein.

Scrg1, a novel protein of the CNS is targeted to the large dense-core vesicles in neuronal cells.

GeneRIF

Dron et al., Villejuif, France. In Eur J Neurosci, 2003

Scrg1 is associated with the secretory pathway of neuronal cells.

Mouse scrapie responsive gene 1 (Scrg1): genomic organization, physical linkage to sap30, genetic mapping on chromosome 8, and expression in neuronal primary cell cultures.

Dandoy-Dron et al., Villejuif, France. In Genomics, 2000

We have previously reported a transcript of a novel mouse gene (Scrg1) with increased expression in transmissible spongiform encephalopathies and the cloning of the human mRNA analogue.

Characterization of the human analogue of a Scrapie-responsive gene.

Tovey et al., Villejuif, France. In J Biol Chem, 1998

We have recently described a novel mRNA denominated ScRG-1, the level of which is increased in the brains of Scrapie-infected mice (Dandoy-Dron, F., Guillo, F., Benboudjema, L., Deslys, J.-P., Lasmézas, C., Dormont, D., Tovey, M. G., and Dron, M. (1998) J. Biol.

Gene expression in scrapie. Cloning of a new scrapie-responsive gene and the identification of increased levels of seven other mRNA transcripts.

Dron et al., Villejuif, France. In J Biol Chem, 1998

Kinetic analysis revealed a concomitant increase in the levels of ScRG-1, cathepsin S, the C1q B-chain of complement, and beta2 microglobulin mRNA as well as glial fibrillary acidic protein and F4/80 transcripts, markers of astrocytosis and microglial activation, respectively.