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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 06 Dec 2014.

Disabled homolog 1

Scr, Dab1, Sex combs reduced
Members of the F-box protein family, such as FBXL20, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, Antennapedia, ACID, Serum albumin
Papers on Scr
Acute tubulo-interstitial nephritis in Scotland.
New
Bell et al., Dundee, United Kingdom. In Qjm, 28 Dec 2014
Median serum creatinine (sCr) was 327μmol/L at biopsy (106μmol/L at baseline).
Promotion of Colorectal Cancer Invasion and Metastasis Through Activation of Notch-Dab1-Abl-RhoGEF Protein Trio.
New
Taketo et al., Kyoto, Japan. In Cancer Discov, 28 Dec 2014
Here we show that one of the genes induced by Notch signaling in CRC is DAB1/Dab1.
Synergetic Effects of Carboxymethyl-Hexanoyl Chitosan and Cationic Polyurethane-Short Branch PEI in miR122 Gene Delivery: Accelerated Differentiation of iPSCs into Mature Hepatocyte-like Cells and Improved Stem Cell therapy in a Hepatic Failure Model.
New
Huang et al., Taipei, Taiwan. In Acta Biomater, 21 Dec 2014
Furthermore, intrahepatic delivery of miR122-iPSC-Heps, but not miR-Scr-iPSC-Heps, improved liver functions and rescued recipient survival, and CHC-mediated delivery showed a better efficacy than that using PBS as delivery vehicle.
The Effects of Tai Chi on the Renal and Cardiac Functions of Patients with Chronic Kidney and Cardiovascular Diseases.
New
Yao et al., China. In J Phys Ther Sci, 30 Nov 2014
[Results] The 12 weeks Tai Chi intervention improved the estimated glomerular filtration rate (eGFR), left ventricular ejection fraction (LVEF), and the high density lipoprotein (HDL) level, and decreased the serum creatintine (Scr) level, heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), and the total cholesterol (CH), triglyceride (TG) and low density lipoprotein (LDL) levels.
Comparison of serum concentrations of symmetric dimethylarginine and creatinine as kidney function biomarkers in healthy geriatric cats fed reduced protein foods enriched with fish oil, L-carnitine, and medium-chain triglycerides.
New
Jewell et al., Corvallis, United States. In Vet J, 22 Nov 2014
Glomerular filtration rate (GFR), serum biochemistries, renal function biomarkers including serum creatinine (sCr) and symmetrical dimethylarginine (SDMA), and plasma metabolomic profiles were measured at baseline, and at 1.5, 3, and 6 months.
Molecular markers for ischemia, do we have something better then creatinine and glomerular filtration rate?
Review
Russo et al., New York City, United States. In Arch Esp Urol, 2013
Serum creatinine (sCr) is the current gold standard for measuring changes in kidney function and identifying AKI.
Abnormal grooming activity in Dab1(scm) (scrambler) mutant mice.
GeneRIF
Lalonde et al., Vandœuvre-lès-Nancy, France. In Behav Brain Res, 2012
This study demonistrated that Dab1(scm) (scrambler) mutant mice show the Abnormal grooming activity.
Dimer formation via the homeodomain is required for function and specificity of Sex combs reduced in Drosophila.
GeneRIF
Gehring et al., Basel, Switzerland. In Dev Biol, 2012
Results indicate that Scr functions as a homodimer to increase its transcriptional specificity and suggest that the formation of homeodomain (HD) homo- or heterodimers might underlie the functional distinction between very similar HD proteins in vivo.
Splice-mediated motif switching regulates disabled-1 phosphorylation and SH2 domain interactions.
GeneRIF
Godbout et al., Edmonton, Canada. In Mol Cell Biol, 2012
coordinated expression of specific Dab1 isoforms in different populations of cells in the developing brain contributes to precise neuronal migration by modulating the activity of subsets of Dab1 downstream effectors
Impact of the Reelin signaling cascade (ligands-receptors-adaptor complex) on cognition in schizophrenia.
GeneRIF
Kalaydjieva et al., Perth, Australia. In Am J Med Genet B Neuropsychiatr Genet, 2012
Variation in genes encoding proteins at the gateway of Reelin signaling: ligands RELN and APOE, their common receptors APOER2 and VLDLR, and adaptor DAB1, was examined.
Reelin regulates differentiation of neural stem cells by activation of notch signaling through Disabled-1 tyrosine phosphorylation.
GeneRIF
Sugaya et al., Orlando, United States. In Can J Physiol Pharmacol, 2012
show that Reelin-stimulated Notch-1 activation is dependent on Reelin signaling
[Significance of urokinase and its inhibitors in the invasiveness and metastasing of malignant tumors].
Review
Penka et al., Brno, Czech Republic. In Vnitr Lek, 2012
At the same time, direct signalling pathway via Jak/STAT cascade utilising signalling transduction of Scr-like protein tyrosine kinase have also been described.
Molecular targeted therapies in head and neck cancer--an update of recent developments-.
Review
Sudhoff et al., Bielefeld, Germany. In Head Neck Oncol, 2009
But inhibitors of alternative targets, such as Scr and proteasomes, have already been evaluated in early clinical trials with HNSCC patients.
Interactions between advanced glycation end-products (AGE) and their receptors in the development and progression of diabetic nephropathy - are these receptors valid therapeutic targets.
Review
Forbes et al., Melbourne, Australia. In Curr Drug Targets, 2009
AGEs elicit their receptor mediated effects via their engagement with numerous receptors and binding proteins which are broadly thought to be either inflammatory (RAGE and AGE-R2) or clearance receptors (AGE-R1, AGE-R3, CD36, Scr-II, FEEL-1 and FEEL-2).
Non-random inactivation of large common fragile site genes in different cancers.
Review
Smith et al., Rochester, United States. In Cytogenet Genome Res, 2006
To determine if there was selection for the inactivation of different large CFS genes in different cancers, we examined the expression of 13 of the 20 known large CFS genes: FHIT, WWOX, PARK2, GRID2, NBEA, DLG2, RORA isoforms 1 and 4, DAB1, CNTNAP2, DMD, IL1RAPL1, IMMP2L and LARGE in breast, ovarian, endometrial and brain cancers using real-time RT-PCR analysis.
Direct demonstration of an intramolecular SH2-phosphotyrosine interaction in the Crk protein.
Impact
Kay et al., Toronto, Canada. In Nature, 1995
Many signal transduction processes are mediated by the binding of Scr-homology-2 (SH2) domains to phosphotyrosine (pTyr)-containing proteins.
Control of cell fates in the central body region of C. elegans by the homeobox gene lin-39.
Impact
Horvitz et al., Cambridge, United States. In Cell, 1993
lin-39 encodes a protein with an Antennapedia class homeodomain, most similar to those of the Drosophila homeotic genes Deformed and Sex combs reduced, and is located in a homeotic gene cluster with two other regional homeotic genes, mab-5 and egl-5.
The specificities of Sex combs reduced and Antennapedia are defined by a distinct portion of each protein that includes the homeodomain.
Impact
Gehring et al., Basel, Switzerland. In Cell, 1990
The sequence requirements for distinguishing the functional specificities of two homeodomain proteins, Antennapedia and Sex combs reduced, involved in the specification of segmental identities in Drosophila, have been determined.
Differential expression of bithorax complex genes in the absence of the extra sex combs and trithorax genes.
Impact
Ingham, In Nature, 1984
Each body segment of Drosophila follows a unique developmental pathway, controlled by the selective expression of homoeotic genes such as Sex combs reduced (Scr)and the bithorax complex (BX-C).
The molecular organization of the Antennapedia locus of Drosophila.
Impact
Kaufman et al., In Cell, 1983
The Antennapedia complex (ANT-C) of Drosophila is a cluster of genes involved in the regulation of morphogenesis, including at least three homoeotic loci (Antp, Scr, and pb), in which mutations cause switches of cell fates from one developmental pathway to another.
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