gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Disabled homolog 1

Scr, Dab1, Sex combs reduced
Members of the F-box protein family, such as FBXL20, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008] (from NCBI)
Papers on Scr
Abnormal grooming activity in Dab1(scm) (scrambler) mutant mice.
GeneRIF
Lalonde et al., Vandœuvre-lès-Nancy, France. In Behav Brain Res, 2012
This study demonistrated that Dab1(scm) (scrambler) mutant mice show the Abnormal grooming activity.
Dimer formation via the homeodomain is required for function and specificity of Sex combs reduced in Drosophila.
GeneRIF
Gehring et al., Basel, Switzerland. In Dev Biol, 2012
Results indicate that Scr functions as a homodimer to increase its transcriptional specificity and suggest that the formation of homeodomain (HD) homo- or heterodimers might underlie the functional distinction between very similar HD proteins in vivo.
Splice-mediated motif switching regulates disabled-1 phosphorylation and SH2 domain interactions.
GeneRIF
Godbout et al., Edmonton, Canada. In Mol Cell Biol, 2012
coordinated expression of specific Dab1 isoforms in different populations of cells in the developing brain contributes to precise neuronal migration by modulating the activity of subsets of Dab1 downstream effectors
Impact of the Reelin signaling cascade (ligands-receptors-adaptor complex) on cognition in schizophrenia.
GeneRIF
Kalaydjieva et al., Perth, Australia. In Am J Med Genet B Neuropsychiatr Genet, 2012
Variation in genes encoding proteins at the gateway of Reelin signaling: ligands RELN and APOE, their common receptors APOER2 and VLDLR, and adaptor DAB1, was examined.
Reelin regulates differentiation of neural stem cells by activation of notch signaling through Disabled-1 tyrosine phosphorylation.
GeneRIF
Sugaya et al., Orlando, United States. In Can J Physiol Pharmacol, 2012
show that Reelin-stimulated Notch-1 activation is dependent on Reelin signaling
share on facebooktweetadd +1mail to friends