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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 25 Jan 2016.

Disabled homolog 1

Scr, Dab1, Sex combs reduced
Members of the F-box protein family, such as FBXL20, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, Antennapedia, ACID, V1a
Papers on Scr
CRISPR/Cas9 Mutagenesis Reveals Versatile Roles of Hox Genes in Crustacean Limb Specification and Evolution.
Patel et al., Berkeley, United States. In Curr Biol, 11 Feb 2016
In the mouth, Scr and Antp confer the part-gnathal, part-thoracic hybrid identity of the maxilliped, and Scr and Dfd prevent antennal identity in posterior head segments.
Kaiso, a transcriptional repressor, promotes cell migration and invasion of prostate cancer cells through regulation of miR-31 expression.
Yates et al., United States. In Oncotarget, 30 Jan 2016
Comparative analysis of miRNA arrays revealed that 13 miRNAs were significantly altered (> 1.5 fold, p < 0.05) in sh-Kaiso PC-3 compared to sh-Scr control cells.
High Dose of Atorvastatin for the Treatment of Contrast-Induced Nephropathy After Carotid Artery Stenting.
He et al., Quanzhou, China. In Am J Ther, 29 Jan 2016
In patients treated with high-dose atorvastatin, no significant change was observed in levels of serum creatinine (Scr), blood urea nitrogen (BUN), creatinine clearance, and high-sensitivity C-reactive protein after the CAS procedure (P > 0.05).
Does the parasite-mediated selection drive the MHC class IIB diversity in wild populations of European chub (Squalius cephalus)?
Šimková et al., Brno, Czech Republic. In Parasitol Res, 23 Jan 2016
DAB1-like alleles were more involved in associations with ectoparasites, while DAB3-like alleles were positively associated with endoparasites which could suggest potential differences between DAB genes caused by different selection pressure.
[Protective effects of Zhenwutang on cardiac function in mice with uremic cardiomyopathy induced by subtotal nephrectomy].
Yan et al., Guangzhou, China. In Nan Fang Yi Ke Da Xue Xue Bao, 20 Jan 2016
RESULTS: Compared with the sham-operated group, the mice in the model group showed significantly lowered body weight and increased heart weight, heart index, left ventricular posterior wall thickness in diastole (LVPWd) and in systole (LVPWs), blood urea nitrogen (BUN) and serum creatinine (Scr) (P<0.05);
Genome-wide association study of 25(OH) Vitamin D concentrations in Punjabi Sikhs: Results of the Asian Indian diabetic heart study.
Sanghera et al., Oklahoma City, United States. In J Steroid Biochem Mol Biol, 15 Jan 2016
Additionally, our study replicated 3 of 5 known GWAS genes associated with 25(OH)D concentrations including GC (p=0.007) and CYP2R1 (p=0.019) reported in Europeans and the DAB1 (p=0.003), reported in Hispanics.
Risk Factors of Parathyroid Dysfunction in Elderly Patients with Chronic Kidney Disease Undergoing Hemodialysis.
Zhang et al., China. In Adv Clin Exp Med, Nov 2015
Before dialysis, fasting blood samples were initially collected, then hemoglobin (Hb), serum creatinine (Scr), blood urea nitrogen (BUN), calcium, phosphorus, intact parathyroid hormone (iPTH), high-sensitivity C-reactive protein (HsCRP) and albumin (Alb) were measured.
Prehospitalization Risk Factors for Acute Kidney Injury during Hospitalization for Serious Infections in the REGARDS Cohort.
Safford et al., United States. In Nephron Extra, Sep 2015
Using the Kidney Disease Improving Global Outcomes (KDIGO) criteria, we defined AKI as an increase in serum creatinine (sCr) ≥0.3 mg/dl from the first inpatient sCr measurement during the first 7 hospitalization days.
[Analysis on factors relevant to operation success rate of internal arteriovenous fistula used in pediatric patients with end stage renal disease].
Shen et al., Beijing, China. In Zhonghua Er Ke Za Zhi, Sep 2015
Factors like sex, choice of operation side, choice of operation vessel, anesthesia, urine protein, model of vascular suture line, age of surgery, inner diameter of anastomotic stoma, hemoglobin (Hb), platelet (Plt), hematocrit (Hct), coagulation function (prothrombin time, PT, fibrinogen, Fib, activated partial thromboplastin time, APTT), creatinine (Scr), Ca²⁺, left ventricular ejection fraction (LVEF), blood pressure (before, during and after surgery) were collected retrospectively.
Effect of dexmedetomidine on rats with renal ischemia-reperfusion injury and the expression of tight junction protein in kidney.
Hou et al., Shenyang, China. In Int J Clin Exp Med, 2014
The kidneys in each group were made out pathologic slices after 6 h I/R, stained with HE; blood samples were taken with separation plasma, creatinine (Scr) and urea nitrogen (BUN) were detected by automatic biochemical analyzer; IL-1β and TNF-α were detected by Enzyme-linked Immunosorbent Assay (ELISA); the expression level of tight junction protein ZO-1 and protein occludin in kidney were detected by Western-blot.
Abnormal grooming activity in Dab1(scm) (scrambler) mutant mice.
Lalonde et al., Vandœuvre-lès-Nancy, France. In Behav Brain Res, 2012
This study demonistrated that Dab1(scm) (scrambler) mutant mice show the Abnormal grooming activity.
Dimer formation via the homeodomain is required for function and specificity of Sex combs reduced in Drosophila.
Gehring et al., Basel, Switzerland. In Dev Biol, 2012
Results indicate that Scr functions as a homodimer to increase its transcriptional specificity and suggest that the formation of homeodomain (HD) homo- or heterodimers might underlie the functional distinction between very similar HD proteins in vivo.
Splice-mediated motif switching regulates disabled-1 phosphorylation and SH2 domain interactions.
Godbout et al., Edmonton, Canada. In Mol Cell Biol, 2012
coordinated expression of specific Dab1 isoforms in different populations of cells in the developing brain contributes to precise neuronal migration by modulating the activity of subsets of Dab1 downstream effectors
Impact of the Reelin signaling cascade (ligands-receptors-adaptor complex) on cognition in schizophrenia.
Kalaydjieva et al., Perth, Australia. In Am J Med Genet B Neuropsychiatr Genet, 2012
Variation in genes encoding proteins at the gateway of Reelin signaling: ligands RELN and APOE, their common receptors APOER2 and VLDLR, and adaptor DAB1, was examined.
Reelin regulates differentiation of neural stem cells by activation of notch signaling through Disabled-1 tyrosine phosphorylation.
Sugaya et al., Orlando, United States. In Can J Physiol Pharmacol, 2012
show that Reelin-stimulated Notch-1 activation is dependent on Reelin signaling
Direct demonstration of an intramolecular SH2-phosphotyrosine interaction in the Crk protein.
Kay et al., Toronto, Canada. In Nature, 1995
Many signal transduction processes are mediated by the binding of Scr-homology-2 (SH2) domains to phosphotyrosine (pTyr)-containing proteins.
Control of cell fates in the central body region of C. elegans by the homeobox gene lin-39.
Horvitz et al., Cambridge, United States. In Cell, 1993
lin-39 encodes a protein with an Antennapedia class homeodomain, most similar to those of the Drosophila homeotic genes Deformed and Sex combs reduced, and is located in a homeotic gene cluster with two other regional homeotic genes, mab-5 and egl-5.
The specificities of Sex combs reduced and Antennapedia are defined by a distinct portion of each protein that includes the homeodomain.
Gehring et al., Basel, Switzerland. In Cell, 1990
The sequence requirements for distinguishing the functional specificities of two homeodomain proteins, Antennapedia and Sex combs reduced, involved in the specification of segmental identities in Drosophila, have been determined.
Differential expression of bithorax complex genes in the absence of the extra sex combs and trithorax genes.
Ingham, In Nature, 1984
Each body segment of Drosophila follows a unique developmental pathway, controlled by the selective expression of homoeotic genes such as Sex combs reduced (Scr)and the bithorax complex (BX-C).
The molecular organization of the Antennapedia locus of Drosophila.
Kaufman et al., In Cell, 1983
The Antennapedia complex (ANT-C) of Drosophila is a cluster of genes involved in the regulation of morphogenesis, including at least three homoeotic loci (Antp, Scr, and pb), in which mutations cause switches of cell fates from one developmental pathway to another.
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