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Sterol carrier protein 2

SCP2, sterol carrier protein-2, SCPx
This gene encodes two proteins: sterol carrier protein X (SCPx) and sterol carrier protein 2 (SCP2), as a result of transcription initiation from 2 independently regulated promoters. The transcript initiated from the proximal promoter encodes the longer SCPx protein, and the transcript initiated from the distal promoter encodes the shorter SCP2 protein, with the 2 proteins sharing a common C-terminus. Evidence suggests that the SCPx protein is a peroxisome-associated thiolase that is involved in the oxidation of branched chain fatty acids, while the SCP2 protein is thought to be an intracellular lipid transfer protein. This gene is highly expressed in organs involved in lipid metabolism, and may play a role in Zellweger syndrome, in which cells are deficient in peroxisomes and have impaired bile acid synthesis. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms.[provided by RefSeq, Aug 2010] (from NCBI)
Top mentioned proteins: ACID, HAD, CAN, V1a, fibrillin-1
Papers using SCP2 antibodies
Matrix metalloproteinases are expressed during ductal and alveolar mammary morphogenesis, and misregulation of stromelysin-1 in transgenic mice induces unscheduled alveolar development
Supplier
Bissell Mina J. et al., In The Journal of Cell Biology, 1994
... The final vector (pTet-Splice-SL-1:M1-tag) was used for transfection of SCp2 cells together with the pTet.tTAk
Papers on SCP2
Proteome-wide identification of novel ceramide-binding proteins by yeast surface cDNA display and deep sequencing.
New
Liu et al., United States. In Mol Cell Proteomics, Feb 2016
Several novel ceramide-binding domains were discovered, including the EF-hand calcium-binding motif, the heat shock chaperonin-binding motif STI1, the SCP2 sterol-binding domain, and the tetratrico peptide repeat region (TPR) motif.
Synthetic High-Density Lipoprotein-Like Nanocarrier Improved Cellular Transport of Lysosomal Cholesterol in Human Sterol Carrier Protein-Deficient Fibroblasts.
New
Lee et al., South Korea. In J Med Food, Jan 2016
Sterol carrier protein-2 (SCP-2), which is not found in tissues of people with Zellweger syndrome, facilitates the movement of cholesterol within cells, resulting in abnormal accumulation of cholesterol in SCP-2-deficient cells.
Relative contributions of L-FABP, SCP-2/SCP-x, or both to hepatic biliary phenotype of female mice.
New
Schroeder et al., College Station, United States. In Arch Biochem Biophys, Jan 2016
Both sterol carrier protein-2/sterol carrier protein-x (SCP-2/SCP-x) and liver fatty acid binding protein (L-FABP) have been proposed to function in hepatobiliary bile acid metabolism/accumulation.
Structural Conservation and Functional Diversity of the Poxvirus Immune Evasion (PIE) Domain Superfamily.
Review
New
Fremont et al., Saint Louis, United States. In Viruses, Sep 2015
For example, cowpox strain Brighton Red appears to encode 10 different PIEs: vCCI, A41, C8, M2, T4 (CPVX203), and the SECRET proteins CrmB, CrmD, SCP-1, SCP-2, and SCP-3.
Sterol Carrier Protein 2, a Critical Host Factor for Dengue Virus Infection, Alters the Cholesterol Distribution in Mosquito Aag2 Cells.
New
Lan et al., Madison, United States. In J Med Entomol, Sep 2015
In mosquito Aedes aegypti, sterol carrier protein 2 (SCP-2) is critical for cellular cholesterol homeostasis.
Loss of L-FABP, SCP-2/SCP-x, or both induces hepatic lipid accumulation in female mice.
New
Kier et al., College Station, United States. In Arch Biochem Biophys, Sep 2015
Although roles for both sterol carrier protein-2/sterol carrier protein-x (SCP-2/SCP-x) and liver fatty acid binding protein (L-FABP) have been proposed in hepatic lipid accumulation, individually ablating these genes has been complicated by concomitant alterations in the other gene product(s).
Synthesis, purification and crystallographic studies of the C-terminal sterol carrier protein type 2 (SCP-2) domain of human hydroxysteroid dehydrogenase-like protein 2.
New
Xie et al., Beijing, China. In Acta Crystallogr Sect F Struct Biol Commun, Jul 2015
Human hydroxysteroid dehydrogenase-like protein 2 (HSDL2) is a member of the short-chain dehydrogenase/reductase (SDR) subfamily of oxidoreductases and contains an N-terminal catalytic domain and a C-termianl sterol carrier protein type 2 (SCP-2) domain.
Microarray analysis of anti-cancer effects of docosahexaenoic acid on human colon cancer model in nude mice.
Zhou et al., Suzhou, China. In Int J Clin Exp Med, 2014
And several genes related to tumor growth and metastasis including COX2, HIF-1α, VEGF-A, COMP, MMP-1, MMP-9, SCP2, SDC3, which were down-regulated by DHA, were further confirmed in HCT-15 cell line using RT-PCR method.
NMR structure and function of Helicoverpa armigera sterol carrier protein-2, an important insecticidal target from the cotton bollworm.
Peng et al., Madison, United States. In Sci Rep, 2014
Sterol Carrier Protein-2 (SCP-2) is an important non-specific lipid transfer protein in insects and appears to be a potential new target.
Novel anticancer agent, SQAP, binds to focal adhesion kinase and modulates its activity.
Sugawara et al., Noda, Japan. In Sci Rep, 2014
This approach identified five SQAP-binding proteins including sterol carrier protein 2, multifunctional enzyme type 2, proteasomal ubiquitin receptor, UV excision repair protein and focal adhesion kinase (FAK).
PPARα signal pathway gene expression is associated with fatty acid content in yak and cattle longissimus dorsi muscle.
Yan et al., Lanzhou, China. In Genet Mol Res, 2014
The mRNA expression levels of FABP4 (P < 0.05), SCP2 (P < 0.05), and APOA1 (P < 0.01) in yaks were significantly lower than those in cattle.
The diverse roles of RNA polymerase II C-terminal domain phosphatase SCP1.
Review
Kim et al., Ch'ŏngju, South Korea. In Bmb Rep, 2014
The subfamily includes Small CTD phosphatases, like SCP1, SCP2, SCP3, TIMM50, HSPC129 and UBLCP.
Metabolic neuropathies and myopathies.
Review
Bertini et al., Roma, Italy. In Handb Clin Neurol, 2012
On the other hand, lysosomal (mucopolysaccharidosis, Gaucher and Fabry diseases), mitochondriopathic (mitochondrial or nuclear mutations or mDNA depletion), peroxisomal (adrenomyeloneuropathy, Refsum disease, sterol carrier protein-2 deficiency, cerebrotendinous xanthomatosis, α-methylacyl racemase deficiency) diseases are multisystemic disorders involving also the heart, liver, brain, retina, and kidney.
Intracellular cholesterol-binding proteins enhance HDL-mediated cholesterol uptake in cultured primary mouse hepatocytes.
GeneRIF
Schroeder et al., College Station, United States. In Am J Physiol Gastrointest Liver Physiol, 2012
liver fatty acid-binding protein, the single most prevalent hepatic cytosolic protein that binds cholesterol, was upregulated twofold in SCP-2 null hepatocytes
The Peroxisomal Targeting Signal 1 in sterol carrier protein 2 is autonomous and essential for receptor recognition.
GeneRIF
Stanley et al., Hamburg, Germany. In Bmc Biochem, 2010
The Peroxisomal targeting signal 1 in Scp2 is autonomous and is essential for binding to pex5.
Sterol carrier protein-2 (SCP-2) involvement in cholesterol hydroperoxide cytotoxicity as revealed by SCP-2 inhibitor effects.
GeneRIF
Girotti et al., Milwaukee, United States. In J Lipid Res, 2010
cellular SCP-2 not only binds and translocates cholesterol but also cholesterol hydroperoxides, thus expanding their redox toxicity and signaling ranges under oxidative stress conditions
An approach based on a genome-wide association study reveals candidate loci for narcolepsy.
GeneRIF
Tokunaga et al., Tokyo, Japan. In Hum Genet, 2010
Statistical analysis indicated that six genes, NFATC2, SCP2, CACNA1C, TCRA, POLE, and FAM3D, were associated with narcolepsy.
Effect of sterol carrier protein-2 gene ablation on HDL-mediated cholesterol efflux from cultured primary mouse hepatocytes.
GeneRIF
Schroeder et al., College Station, United States. In Am J Physiol Gastrointest Liver Physiol, 2010
SCP-2 expression plays a significant role in HDL-mediated cholesterol efflux by regulating the size of rapid vs. slow cholesterol efflux pools and/or eliciting concomitant upregulation of L-FABP in cultured primary hepatocytes.
Caveolin, sterol carrier protein-2, membrane cholesterol-rich microdomains and intracellular cholesterol trafficking.
Review
Kier et al., College Station, United States. In Subcell Biochem, 2009
Further, the role of cholesterol-rich membrane microdomains as targets for intracellular cholesterol trafficking proteins such as sterol carrier protein-2 (SCP-2) that facilitate cholesterol uptake and transcellular transport for targeting storage (cholesterol esters) or efflux is only beginning to be understood.
Oncogene-transformed granulosa cells as a model system for the study of steroidogenic processes.
Review
Strauss et al., Israel. In J Steroid Biochem Mol Biol, 1992
Since cholesterol import into mitochondria is essential for steroidogenesis, the expression of the peripheral benzodiazepine receptor (PBR) and the sterol carrier protein 2 was characterized in these cells.
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