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SCO cytochrome oxidase deficient homolog 2

SCO2
Cytochrome c oxidase (COX) catalyzes the transfer of electrons from cytochrome c to molecular oxygen, which helps to maintain the proton gradient across the inner mitochondrial membrane that is necessary for aerobic ATP production. Human COX is a multimeric protein complex that requires several assembly factors; this gene encodes one of the COX asembly factors. The encoded protein is a metallochaperone that is involved in the biogenesis of cytochrome c oxidase subunit II. Mutations in this gene are associated with fatal infantile encephalocardiomyopathy. [provided by RefSeq, Dec 2009] (from NCBI)
Top mentioned proteins: CAN, SCO1, HAD, p53, AGE
Papers on SCO2
SCO2 mediates oxidative stress-induced glycolysis to OXPHOS switch in hematopoietic stem cells.
New
Pang et al., Cincinnati, United States. In Stem Cells, Jan 2016
Finally, oxidative stress-induced glycolysis-to-OXPHOS switch is mediated by SCO2.
The Role of Cerebral Oxygenation and Regional Cerebral Blood Flow on Tolerance to Central Hypovolemia.
New
Rickards et al., United States. In Am J Physiol Regul Integr Comp Physiol, Jan 2016
We hypothesized that individuals with high tolerance to central hypovolemia would exhibit protection of cerebral oxygenation (ScO2), and prolonged preservation of CBF in the posterior versus anterior cerebral circulation.
Chemical Composition and Biological Activity of Extracts Obtained by Supercritical Extraction and Ethanolic Extraction of Brown, Green and Red Propolis Derived from Different Geographic Regions in Brazil.
New
Padilha et al., Aracaju, Brazil. In Plos One, Dec 2015
Considering this fact, this study evaluated propolis extracts obtained by supercritical extraction (SCO2) and ethanolic extraction (EtOH), in eight samples of different types of propolis (red, green and brown), collected from different regions in Brazil.
Genetic alterations in fatty acid transport and metabolism genes are associated with metastatic progression and poor prognosis of human cancers.
New
Chan et al., East Lansing, United States. In Sci Rep, Dec 2015
Our association analysis revealed a uniform pattern of Warburg effect mutations influencing prognosis across all tumor types, while copy number alterations in the electron transport chain gene SCO2, fatty acid uptake (CAV1, CD36) and lipogenesis (PPARA, PPARD, MLXIPL) genes were enriched in metastatic tumors.
Cooperation between COA6 and SCO2 in COX2 maturation during cytochrome c oxidase assembly links two mitochondrial cardiomyopathies.
New
Impact
Deckers et al., Göttingen, Germany. In Cell Metab, Jul 2015
Interestingly, similar to the copper metallochaperone SCO2, loss of COA6 causes cardiomyopathy in humans.
Upregulation of energy metabolism-related, p53-target TIGAR and SCO2 in HuH-7 cells with p53 mutation by geranylgeranoic acid treatment.
Shidoji et al., Nagasaki, Japan. In Biomed Res, 2014
Here, we show that a branched-chain C-20 polyunsaturated fatty acid, geranylgeranoic acid (GGA), induces upregulation of the cellular protein levels of TP53-induced glycolysis and apoptosis regulator (TIGAR) and synthesis of cytochrome c oxidase 2 (SCO2) in human hepatoma-derived HuH-7cells harboring the mutant TP53 gene, suggesting that GGA may shift an energetic state of the tumor cells from aerobic glycolysis to mitochondrial respiration.
Use of whole-exome sequencing to determine the genetic basis of multiple mitochondrial respiratory chain complex deficiencies.
Impact
Chinnery et al., Newcastle upon Tyne, United Kingdom. In Jama, 2014
However, atypical clinical features were present in some patients, including normal liver function and Leigh syndrome (subacute necrotizing encephalomyelopathy) seen in association with TRMU mutations and no cardiomyopathy with founder SCO2 mutations.
Oxidative folding in chloroplasts.
Review
Kieselbach, Umeå, Sweden. In Antioxid Redox Signal, 2013
The proteins' low quantum yield of Photosystem II 1 (LQY1, At1g75690) and snowy cotyledon 2 (SCO2, At3g19220) exhibits protein disulfide isomerase activity and is suggested to function in the assembly and repair of Photosystem II (PSII), and the biogenesis of thylakoids in cotyledons, respectively.
Mitochondrial cardioencephalomyopathy due to a novel SCO2 mutation in a Brazilian patient: case report and literature review.
Review
Hirano et al., Belo Horizonte, Brazil. In Jama Neurol, 2013
OBJECTIVES: To review all patients with SCO2 mutations and to describe a Brazilian patient with cardioencephalomyopathy carrying compound heterozygous mutations in SCO2, one being the known pathogenic p.E140K mutation and the other a novel 12-base pair (bp) deletion at nucleotides 1519 through 1530 (c.1519_1530del).
Synthesis of cytochrome C oxidase 2: a p53-dependent metabolic regulator that promotes respiratory function and protects glioma and colon cancer cells from hypoxia-induced cell death.
GeneRIF
Rieger et al., Frankfurt am Main, Germany. In Oncogene, 2012
wild-type p53 gene silencing reduced the expression of synthesis of cytochrome c oxidase 2 (SCO2), an effector necessary for respiratory chain function
The SCO2 protein disulphide isomerase is required for thylakoid biogenesis and interacts with LHCB1 chlorophyll a/b binding proteins which affects chlorophyll biosynthesis in Arabidopsis seedlings.
GeneRIF
Albrecht et al., Australia. In Plant J, 2012
SCO2 interacts with LHCB1 proteins and is co-expressed with genes encoding proteins of the tetrapyrrole biosynthesis pathway. Mutations in sco2 affect the accumulation of the chlorophyll precursor protochlorophyllide.
Regulatory role of p53 in cancer metabolism via SCO2 and TIGAR in human breast cancer.
GeneRIF
Lee et al., Seoul, South Korea. In Hum Pathol, 2012
These results suggest that p53 can modulate the metabolic pathways via the proteins SCO2 and TIGAR in human breast cancer.
Selective divalent copper chelation for the treatment of diabetes mellitus.
Review
Cooper, Manchester, United Kingdom. In Curr Med Chem, 2011
These examples illustrate how impaired regulation of copper transport pathways can cause organ damage and provide important insights into the impact of defects in specific molecular processes, including those catalyzed by the copper-transporting ATPases, ATP7A (mutated in Menkes disease), ATP7B (Wilson's disease), and the copper chaperones such as those for cytochrome c oxidase, SCO1 and SCO2.
Regulation of glucose metabolism by p53: emerging new roles for the tumor suppressor.
Review
Mahdi et al., Lucknow, India. In Oncotarget, 2011
p53 regulates aerobic respiration at the glycolytic and oxidative phosphorylation (OXPHOS) steps via transcriptional regulation of its downstream genes TP53-induced glycolysis regulator (TIGAR) and synthesis of cytochrome c oxidase (SCO2).
NF-κB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration.
Impact
Franzoso et al., London, United Kingdom. In Nat Cell Biol, 2011
This NF-κB-dependent metabolic pathway involves stimulation of oxidative phosphorylation through upregulation of mitochondrial synthesis of cytochrome c oxidase 2 (SCO2; ref. ).
Physical exercise regulates p53 activity targeting SCO2 and increases mitochondrial COX biogenesis in cardiac muscle with age.
GeneRIF
Qian et al., Shanghai, China. In Plos One, 2010
Data suggest that physical exercise attenuates age-related changes in mitochondrial COX biogenesis and p53 activity targeting SCO2 and mitochondria, and thereby induces antisenescent and protective effects in cardiac muscle.
Unexpected vascular enrichment of SCO1 over SCO2 in mammalian tissues: implications for human mitochondrial disease.
GeneRIF
Schon et al., New York City, United States. In Am J Pathol, 2010
Results describe the tissue distribution of SCO1 and SCO2 in mouse and human tissues.
The role of p53 in cell metabolism.
Review
Wang et al., Suzhou, China. In Acta Pharmacol Sin, 2010
p53 regulates OXPHOS through the transcriptional regulation of fructose-2,6-bisphosophatase, TP53-induced glycolysis regulator (TIGAR) and synthesis of cytochrome c oxidase (SCO2) subunit of complex IV of the electron transport chain.
The human cytochrome c oxidase assembly factors SCO1 and SCO2 have regulatory roles in the maintenance of cellular copper homeostasis.
Impact
GeneRIF
Shoubridge et al., Montréal, Canada. In Cell Metab, 2007
These results suggest a mitochondrial pathway for the regulation of cellular copper content that involves signaling through SCO1 and SCO2, perhaps by their thiol redox or metal-binding state.
Differential utilization of two ATP-generating pathways is regulated by p53.
Impact
Benchimol et al., Toronto, Canada. In Cancer Cell, 2006
In a recent article, Matoba et al. report that the p53 tumor suppressor regulates the expression of SCO2, a protein that is required for the assembly of cytochrome c oxidase (COX), a multimeric protein complex required for oxidative phosphorylation.
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