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Human immunodeficiency virus type I enhancer binding protein 1

This gene encodes a transcription factor belonging to the ZAS family, members of which are large proteins that contain a ZAS domain - a modular protein structure consisting of a pair of C2H2 zinc fingers with an acidic-rich region and a serine/threonine-rich sequence. These proteins bind specifically to the DNA sequence motif, GGGACTTTCC, found in the enhancer elements of several viral promoters, including human immunodeficiency virus (HIV), and to related sequences found in the enhancer elements of a number of cellular promoters. This protein binds to this sequence motif, suggesting a role in the transcriptional regulation of both viral and cellular genes. [provided by RefSeq, Oct 2011] (from NCBI)
Top mentioned proteins: MIBP1, CAN, DSP, Qin, TGF-beta
Papers on Schnurri
Combined behavioral studies and in vivo imaging of inflammatory response and expression of mGlu5 receptors in schnurri-2 knockout mice.
Brownell et al., United States. In Neurosci Lett, Dec 2015
Schnurri-2 (Shn-2) knockout (KO) mice have been proposed as a preclinical neuroinflammatory schizophrenia model.
Molecular Mechanisms and Timing of Cortical Immune Activation in Schizophrenia.
Lewis et al., Pittsburgh, United States. In Am J Psychiatry, Dec 2015
RESULTS: Schizophrenia subjects had markedly higher mRNA levels for interleukin 6 (IL-6) (+379%) and interferon-β (+29%), which induce IFITM expression; lower mRNA levels for Schnurri-2 (-10%), a transcriptional inhibitor that lowers IFITM expression; and higher mRNA levels for nuclear factor-κB (+86%), a critical transcription factor that mediates cytokine regulation of immune-related gene expression.
Golgi anti-apoptotic proteins are highly conserved ion channels that affect apoptosis and cell migration.
Smith et al., Cambridge, United Kingdom. In J Biol Chem, Jun 2015
Mutation of residue Glu-207 or -178 reduced the effects of GAAP on cell migration and adhesion without affecting protection from apoptosis.
BMP-dependent gene repression cascade in Drosophila eggshell patterning.
Pyrowolakis et al., Freiburg, Germany. In Dev Biol, May 2015
We show that Dpp directly regulates brk transcription through Smad- and Schnurri (Shn)-dependent repression.
CTCF-dependent co-localization of canonical Smad signaling factors at architectural protein binding sites in D. melanogaster.
Corces et al., Atlanta, United States. In Cell Cycle, 2014
We have mapped Drosophila TGF-β signaling factors Mad, dSmad2, Medea, and Schnurri genome-wide in Kc cells and find that numerous sites for these factors overlap with the architectural protein CTCF.
[Immaturity of brain as an endophenotype of neuropsychiatric disorders].
Miyakawa et al., In Nihon Shinkei Seishin Yakurigaku Zasshi, 2014
So far, the iDG phenotype and similar behavioral abnormalities have been found in Schnurri-2 knockout, SNAP-25 mutant, and forebrain-specific calcineurin knockout mice.
Immature dentate gyrus: an endophenotype of neuropsychiatric disorders.
Miyakawa et al., Japan. In Neural Plast, 2012
To date, the iDG phenotype and shared behavioral abnormalities (including working memory deficit and hyperlocomotor activity) have been discovered in Schnurri-2 knockout, mutant SNAP-25 knock-in, and forebrain-specific calcineurin knockout mice.
Six-transmembrane topology for Golgi anti-apoptotic protein (GAAP) and Bax inhibitor 1 (BI-1) provides model for the transmembrane Bax inhibitor-containing motif (TMBIM) family.
Smith et al., Cambridge, United Kingdom. In J Biol Chem, 2012
Data indicate that GAAP and BI-1 have a six membrane-spanning topology with cytosolic N and C termini and a C-terminal reentrant loop.
A follow-up study of a genome-wide association scan identifies a susceptibility locus for venous thrombosis on chromosome 6p24.1.
Rosendaal et al., Marseille, France. In Am J Hum Genet, 2010
HIVEP1 rs169713C allele was associated with venous thrombosis.
CLIC4 and Schnurri-2: a dynamic duo in TGF-beta signaling with broader implications in cellular homeostasis and disease.
Yuspa et al., Bethesda, United States. In Nucleus, 2010
Recently, it was discovered that TGF-beta causes CLIC4 to associate with Schnurri-2 and together they translocate to the nucleus and dissociate thereafter.
Regulation of bone formation and immune cell development by Schnurri proteins.
Glimcher et al., Boston, United States. In Adv Exp Med Biol, 2009
Although identified over a decade ago, the function and physiological significance of the mammalian Schnurri protein family remained largely unknown.
Human Golgi antiapoptotic protein modulates intracellular calcium fluxes.
van Kuppeveld et al., Nijmegen, Netherlands. In Mol Biol Cell, 2009
Data demonstrate that h-GAAP modulates intracellular Ca(2+) fluxes induced by both physiological and apoptotic stimuli.
TGF-beta signalling is regulated by Schnurri-2-dependent nuclear translocation of CLIC4 and consequent stabilization of phospho-Smad2 and 3.
Yuspa et al., Bethesda, United States. In Nat Cell Biol, 2009
CLIC4 (chloride intracellular channel 4), a multifunctional protein that traffics between the cytoplasm and nucleus, interacts with Schnurri-2, a transcription factor in the bone morphogenetic protein (BMP) signalling pathway.
Finding partners: how BMPs select their targets.
Cho et al., Irvine, United States. In Dev Dyn, 2009
We highlight recent studies suggesting the evolutionary conservation of BMP target gene regulation signaling by Schnurri family zinc finger proteins.
The Drosophila Smad cofactor Schnurri engages in redundant and synergistic interactions with multiple corepressors.
Laughon et al., Madison, United States. In Biochim Biophys Acta, 2009
Shn of Drosophila engages in redundant and synergistic interactions with multiple corepressors.
Comparative genomics and function analysis on BI1 family.
Ma et al., Wuhan, China. In Comput Biol Chem, 2008
The tmbim4 may participate in cell death regulation by interacting with proteins of Bcl-2 family, promoting tumor metastasis, which is deduced from the evolutionary conservation of the membrane protein family containing multiple membrane spanning segments
Regulation of adult bone mass by the zinc finger adapter protein Schnurri-3.
Glimcher et al., Boston, United States. In Science, 2006
Here we show that Schnurri-3 (Shn3), a mammalian homolog of the Drosophila zinc finger adapter protein Shn, is an essential regulator of adult bone formation.
Conversion of an extracellular Dpp/BMP morphogen gradient into an inverse transcriptional gradient.
Basler et al., Zürich, Switzerland. In Cell, 2003
Furthermore, we present genetic and biochemical evidence that the brk silencer serves as a direct target for a protein complex consisting of the Smad homologs Mad/Medea and the zinc finger protein Schnurri.
Murine Schnurri-2 is required for positive selection of thymocytes.
Ishii et al., Tsukuba, Japan. In Nat Immunol, 2001
We show here that mice lacking the transcription factor Schnurri-2 (Shn-2), a large metal-finger protein, had severely defective positive selection of CD4+ and CD8+ cells.
Schnurri mediates Dpp-dependent repression of brinker transcription.
Affolter et al., Basel, Switzerland. In Nat Cell Biol, 2000
Here we show that Schnurri (Shn), a large zinc-finger protein, is essential for Dpp-mediated repression of brk transcription; in contrast, Shn is not required for target-gene activation.
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