Molecular Mechanisms and Timing of Cortical Immune Activation in Schizophrenia.
Pittsburgh, United States. In Am J Psychiatry, Dec 2015
RESULTS: Schizophrenia subjects had markedly higher mRNA levels for interleukin 6 (IL-6) (+379%) and interferon-β (+29%), which induce IFITM expression; lower mRNA levels for Schnurri-2 (-10%), a transcriptional inhibitor that lowers IFITM expression; and higher mRNA levels for nuclear factor-κB (+86%), a critical transcription factor that mediates cytokine regulation of immune-related gene expression.
Comparative genomics and function analysis on BI1 family.
Wuhan, China. In Comput Biol Chem, 2008
The tmbim4 may participate in cell death regulation by interacting with proteins of Bcl-2 family, promoting tumor metastasis, which is deduced from the evolutionary conservation of the membrane protein family containing multiple membrane spanning segments