Genetics of prion diseases.
London, United Kingdom. In Curr Opin Genet Dev, 2013
Complementary studies in mouse have used complex crosses to identify new modifiers such as Cpne8 and provided supporting evidence for previously implicated genes (Rarb and Stmn2).
Uses for JNK: the many and varied substrates of the c-Jun N-terminal kinases.
Australia. In Microbiol Mol Biol Rev, 2006
Many nonnuclear substrates have also been characterized, and these are involved in protein degradation (e.g., the E3 ligase Itch), signal transduction (e.g., adaptor and scaffold proteins and protein kinases), apoptotic cell death (e.g., mitochondrial Bcl2 family members), and cell movement (e.g., paxillin, DCX, microtubule-associated proteins, the stathmin family member SCG10, and the intermediate filament protein keratin 8).