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Stearoyl-Coenzyme A desaturase 2

SCD2, SCD5, Scd5p
Stearoyl-CoA desaturase (SCD; EC is an integral membrane protein of the endoplasmic reticulum that catalyzes the formation of monounsaturated fatty acids from saturated fatty acids. SCD may be a key regulator of energy metabolism with a role in obesity and dislipidemia. Four SCD isoforms, Scd1 through Scd4, have been identified in mouse. In contrast, only 2 SCD isoforms, SCD1 (MIM 604031) and SCD5, have been identified in human. SCD1 shares about 85% amino acid identity with all 4 mouse SCD isoforms, as well as with rat Scd1 and Scd2. In contrast, SCD5 shares limited homology with the rodent SCDs and appears to be unique to primates (Wang et al., 2005 [PubMed 15907797]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: Stearoyl-CoA Desaturase, ACID, CAN, CIs, Insulin
Papers on SCD2
Hypothalamic stearoyl-CoA desaturase-2 (SCD2) controls whole-body energy expenditure.
Velloso et al., Campinas, Brazil. In Int J Obes (lond), Oct 2015
BACKGROUND/OBJECTIVES: Stearoyl-CoA desaturase-2 (SCD2) is the main δ9 desaturase expressed in the central nervous system.
X-ray structure of a mammalian stearoyl-CoA desaturase.
Zhou et al., Houston, United States. In Nature, Sep 2015
Humans have two SCD homologues (SCD1 and SCD5), while mice have four (SCD1-SCD4).
SCD5-induced oleic acid production reduces melanoma malignancy by intracellular retention of SPARC and cathepsin B.
Mattia et al., Roma, Italy. In J Pathol, Jul 2015
We unveiled the role of the stearoyl-CoA desaturase SCD5 in converting saturated FAs into mono-unsaturated FAs during melanoma progression.
Bovine brain region-specific stearoyl-CoA desaturase expression and fatty acid composition.
Corl et al., Blacksburg, United States. In Lipids, Jun 2015
In this study, we sought to determine the relationship between stearoyl-CoA desaturase (SCD) gene isoform expression in the bovine brain and the accumulation of 18:1n-9.
Impact of alogliptin and pioglitazone on lipid metabolism in islets of prediabetic and diabetic Zucker Diabetic Fatty rats.
Olson et al., East Lansing, United States. In Biochem Pharmacol, Jun 2015
Transition of control prediabetic ZDF rats to diabetes was associated with reduced plasma insulin levels, reduced islet insulin content and GSIS, reduced stearoyl-CoA desaturase 2 (SCD 2) expression, and increased islet TAG, diacylglyceride (DAG) and ceramides species containing saturated FA.
Hepatic oleate regulates adipose tissue lipogenesis and fatty acid oxidation.
Ntambi et al., Madison, United States. In J Lipid Res, Feb 2015
To understand the mechanism by which hepatic MUFA production influences adipose tissue stores, we created two liver-specific transgenic mouse models in the SCD1 knockout that express either human SCD5 or mouse SCD3, that synthesize oleate and palmitoleate, respectively.
Saturated phosphatidic acids mediate saturated fatty acid-induced vascular calcification and lipotoxicity.
Miyazaki et al., In J Clin Invest, 2014
Here, we have shown that repression of stearoyl-CoA desaturase (SCD) enzymes, which regulate the intracellular balance of SFAs and unsaturated FAs, and the subsequent accumulation of SFAs in vascular smooth muscle cells (VSMCs), are characteristic events in the development of vascular calcification.
In situ characterizing membrane lipid phenotype of breast cancer cells using mass spectrometry profiling.
Li et al., Beijing, China. In Sci Rep, 2014
The Western blotting assays indicated that the expression of five lipogenesis-related enzymes (i.e., fatty acid synthase 1(FASN1), stearoyl-CoA desaturase 1 (SCD1), stearoyl-CoA desaturase 5 (SCD5), choline kinase α (CKα), and sphingomyelin synthase 1) was associated with the types of the breast cells, and that the SCD1 level in MCF-7 cells was significantly increased relative to other breast cell lines.
Identification of Candidate Biomarkers in Peripheral Blood for Cardiac Allograft Rejection based on Bioinformatics Analysis.
Gong et al., Hangzhou, China. In Ann Transplant, 2014
CONCLUSIONS: RPL7, RPL11, RPS23, RPS25, SCD5, CSF3R, and FPR1 were predicted as candidate biomarkers in peripheral blood for monitoring cardiac AR.
Regulation of the bovine SCD5 promoter by EGR2 and SREBP1.
Corl et al., Blacksburg, United States. In Biochem Biophys Res Commun, 2012
This is the first report of potential regulators of SCD5 transcription.
Modulation of palmitate-induced endoplasmic reticulum stress and apoptosis in pancreatic β-cells by stearoyl-CoA desaturase and Elovl6.
Olson et al., East Lansing, United States. In Am J Physiol Endocrinol Metab, 2011
Overt type 2 diabetes is associated with diminished islet expression of SCD and Elovl6, and this can disrupt desaturation of saturated FAs to MUFAs, rendering beta-cells more susceptible to saturated FA-induced ER stress and apoptosis.
Stearoyl-CoA desaturase 2 is required for peroxisome proliferator-activated receptor gamma expression and adipogenesis in cultured 3T3-L1 cells.
Czech et al., Worcester, United States. In J Biol Chem, 2008
Inhibition of adipogenesis caused by SCD2 depletion was associated with a decrease in PPAR-gamma mRNA and protein, whereas in mature adipocytes loss of SCD2 diminished PPARgamma protein levels, with little change in mRNA levels.
Scd5p mediates phosphoregulation of actin and endocytosis by the type 1 phosphatase Glc7p in yeast.
Cai et al., Singapore, Singapore. In Mol Biol Cell, 2007
Glc7p antagonizes the activity of the Prk1p kinase in regulating the functions of Pan1p and possibly other actin- and endocytosis-related proteins
[Study of the genes expression of SCD-2 and B-FABP in the mice brain of exercise-induced fatigue by genechip cDNA microarray].
Zhang et al., Xi'an, China. In Zhongguo Ying Yong Sheng Li Xue Za Zhi, 2005
Exercise-induced nerve center fatigue is correlated with gene expressions of B-FABP and SCD2.
Regulation of stearoyl-CoA desaturase expression.
Dobrzyn et al., Madison, United States. In Lipids, 2004
Several SCD gene isoforms (SCD1, SCD2, SCD3, and SCD4) exist in mice, and two have been characterized in humans.
Microarrays, antiobesity and the liver.
Castro-Chávez, Guadalajara, Mexico. In Ann Hepatol, 2004
Both models of obesity resistance share many similar phenotypic antiobesity features, however, the perilipin-/- mice had a significant downregulation of stearoyl CoA desaturases scd1 and scd2 in its white adipose tissue, but a normal level of both genes inside the liver, even under high-fat diet.
Regulation of stearoyl-CoA desaturases and role in metabolism.
Miyazaki et al., Madison, United States. In Prog Lipid Res, 2004
Stearoyl-CoA desaturase (SCD) is the rate-limiting enzyme catalyzing the synthesis of monounsaturated fatty acids, mainly oleate (18:1) and palmitoleate (16:1).
Regulation of stearoyl-CoA desaturase genes: role in cellular metabolism and preadipocyte differentiation.
Ntambi et al., Madison, United States. In Biochem Biophys Res Commun, 2000
Stearoyl-CoA desaturase (SCD) is a key rate-limiting enzyme in the synthesis of unsaturated fatty acids by insertion of a cis-double bond in the Delta9 position of fatty acid substrates.
Regulation of stearoyl-CoA desaturase by polyunsaturated fatty acids and cholesterol.
Ntambi, Madison, United States. In J Lipid Res, 1999
A key enzyme involved in this process is the membrane-bound stearoyl-CoA desaturase (SCD) which is the rate-limiting enzyme in the cellular synthesis of monounsaturated fatty acids from saturated fatty acids.
Cooperative interaction of S. pombe proteins required for mating and morphogenesis.
Wigler et al., New York City, United States. In Cell, 1994
We isolated two S. pombe genes, scd1 and scd2, that are required for normal morphology and mating.
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