Signal transduction by VEGF receptors in regulation angiogenesis and lymphangiogenesis
In Cell death and differentiation, 2005
... HDMEC and UM-SCC-1 cells were starved overnight, and treated with 0-50 ng/ml rhEGF, 0-50 ng/ml rhVEGF165, or 0-50 ng/ml rhPlGF (R & D Systems, Minneapolis, MN), 0-50 ng/ml rhVEGF-E (Fitzgerald, Concord, MA), or 0-20 ...
Urinary Biomarkers for Diagnosis of Bladder Cancer: A Systematic Review and Meta-analysis.
In Ann Intern Med, Jan 2016
STUDY SELECTION: 57 studies that evaluated the diagnostic accuracy of quantitative or qualitative nuclear matrix protein 22 (NMP22), qualitative or quantitative bladder tumor antigen (BTA), fluorescence in situ hybridization (FISH), fluorescent immunohistochemistry (ImmunoCyt [Scimedx]), and Cxbladder (Pacific Edge Diagnostics USA) using cystoscopy and histopathology as the reference standard met inclusion criteria.
Cornelia de Lange syndrome.
Copenhagen, Denmark. In Clin Genet, Jul 2015
To date five genes [NIPBL (Nipped-B-like protein), SMC1A (structural maintenance of chromosomes 1A), SMC3 (structural maintenance of chromosomes 3), RAD21 (human homolog of Schizosaccharomyces pombe radiation sensitive mutant 21) and HDAC8 (histone deacetylase 8)] have been associated with CdLS and mutations of these genes comprise the underlying defect in 70% of the patients.
Cohesin complexes with a potential to link mammalian meiosis to cancer.
Guangzhou, China. In Cell Regen (lond), 2012
The first reports characterizing the SMC1 and RAD21 genes, encoding subunits of cohesin, were published 20 years ago; however the exact molecular mechanics of cohesin molecular machine in vivo remains rather obscure notwithstanding ample elegant experiments.
Activation of the innate immune receptor Dectin-1 upon formation of a 'phagocytic synapse'.
Los Angeles, United States. In Nature, 2011
In this study we show that, despite its ability to bind both soluble and particulate β-glucan polymers, Dectin-1 signalling is only activated by particulate β-glucans, which cluster the receptor in synapse-like structures from which regulatory tyrosine phosphatases CD45 and CD148 (also known as PTPRC and PTPRJ, respectively) are excluded (Supplementary Fig. 1).
Rockville, United States. In Unknown Journal, 0001
RESULTS: Urinary biomarkers were associated with sensitivity for bladder cancer that ranged from 0.57 to 0.82 and specificity from 0.74 to 0.88, for positive likelihood ratios from 2.52 to 5.53 and negative likelihood ratios from 0.21 to 0.48 (strength of evidence [SOE]: moderate for quantitative nuclear matrix protein 22 [NMP22], qualitative bladder tumor antigen [BTA], fluorescence in situ hybridization [FISH], and ImmunoCyt(™); low for other biomarkers).