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Secretory carrier membrane protein 3

SCAMP3, propin1
This gene encodes an integral membrane protein that belongs to the secretory carrier membrane protein family. The encoded protein functions as a carrier to the cell surface in post-golgi recycling pathways. This protein is also involved in protein trafficking in endosomal pathways. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011] (from NCBI)
Papers on SCAMP3
Regulation of the MVB pathway by SCAMP3.
Gruenberg et al., Genève, Switzerland. In Traffic, 2012
SCAMP3 has a positive role in sorting into and budding of intralumenal vesicles and thereby controls the process of multivesicular endosome biogenesis.
SCAMP3 is a component of the Salmonella-induced tubular network and reveals an interaction between bacterial effectors and post-Golgi trafficking.
Holden et al., London, United Kingdom. In Cell Microbiol, 2009
SCAMP3 tubules reflect a manipulation of specific post-Golgi trafficking that might allow Salmonella to acquire nutrients and membrane, or to control host immune responses.
SCAMP3 negatively regulates epidermal growth factor receptor degradation and promotes receptor recycling.
Castle et al., Charlottesville, United States. In Mol Biol Cell, 2009
Depletion of SCAMP3 in HeLa cells by inhibitory RNA accelerated degradation of epidermal growth factor receptor (EGFR) and EGF while inhibiting recycling
Three mammalian SCAMPs (secretory carrier membrane proteins) are highly related products of distinct genes having similar subcellular distributions.
Castle et al., Charlottesville, United States. In J Cell Sci, 1997
the SCAMPs may largely function at the same sites during vesicular transport rather than in separate post-Golgi recycling pathways.
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