An emerging role for Hippo-YAP signaling in cardiovascular development.
Augusta, United States. In J Biomed Res, 2014
Recent studies demonstrate that cardiac-specific deletion of the Hippo pathway kinase Mst (STE20-like protein kinases) co-activator WW45 (WW domain-containing adaptor 45), Mst1, Mst2, or Lats2 (large tumor suppressor homologue 2) in mice result in over-grown hearts with elevated cardiomyocyte proliferation.
The Hippo pathway in biological control and cancer development.
Singapore, Singapore. In J Cell Physiol, 2011
The core kinase components Hippo, Salvador, Warts, and Mats in the fly and Mst1/2, WW45, Lats1/2, and Mob1 in mammals phosphorylate and inactivate downstream transcriptional co-activators Yorkie in the fly, Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) in mammals, respectively.
The emerging role of the hippo pathway in cell contact inhibition, organ size control, and cancer development in mammals.
Singapore, Singapore. In Cancer Cell, 2008
The fly core components Hippo, Sav, Wts, and Mats are conserved in mammals as Mst1/2, WW45, LATS1/2, and Mob1.