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Salvador homolog 1

Sav, hWW45, WW45
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a coiled-coil region. It is ubiquitously expressed in adult tissues. The encoded protein is 94% identical to the mouse protein at the amino acid level. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, Warts, MSP, ACID, POLYMERASE
Papers using Sav antibodies
Negative Regulation of Immunoglobulin E–dependent Allergic Responses by Lyn Kinase
Supplier
Rivera Juan et al., In The Journal of Experimental Medicine, 1996
... R53-72), purified mouse IgE (κ isotype control), biotin rat anti–mouse IgE (clone R35-118), and streptavidin-HRP (SAv-HRP) were purchased from BD Biosciences.
Papers on Sav
Radiocesium accumulation properties of Chengiopanax sciadophylloides.
New
Takenaka et al., Nagoya, Japan. In J Environ Radioact, Jan 2016
et Sav.) at the site contained radiocesium (((134),)(137)Cs) at higher concentrations than the other plants.
Epidemics of GI.2 sapovirus in gastroenteritis outbreaks during 2012-2013 in Osaka City, Japan.
New
Kaida et al., Ōsaka, Japan. In J Med Virol, Jan 2016
UNASSIGNED: Sapovirus (SaV) is a causative agent of gastroenteritis in humans in both sporadic cases and outbreaks.
Parallel, open-channel lateral flow (immuno) assay substrate based on capillary-channeled polymer films.
New
Kenneth Marcus et al., United States. In Analyst, Jan 2016
In this demonstration, physical adsorption of a biotinylated-LTL onto the UV-treated PP surface selectively captures Texas Red-labeled streptavidin (SAv-TR) in the presence of enhanced green fluorescence protein (EGFP), which passes without retention in less than 5 s.
Hybrid PET/optical imaging of integrin αVβ3 receptor expression using a (64)Cu-labeled streptavidin/biotin-based dimeric RGD peptide.
New
Kim et al., Seoul, South Korea. In Ejnmmi Res, Dec 2015
Herein, we developed a (64)Cu-labeled AlexaFluor 680-streptavidin ((AF)SAv)/biotin-based dimeric cyclic RGD peptide (RGD2) for hybrid PET/optical imaging of integrin αVβ3 expression.
Warts Phosphorylates Mud to Promote Pins-Mediated Mitotic Spindle Orientation in Drosophila, Independent of Yorkie.
New
Johnston et al., Albuquerque, United States. In Curr Biol, Dec 2015
Knockdown of Hpo, Salvador (Sav), or Warts (Wts) each result in a partial loss of spindle orientation, a phenotype previously described following loss of the Pins-binding protein Mushroom body defect (Mud).
Mechanism of Cell Culture Adaptation of an Enteric Calicivirus, the Porcine Sapovirus Cowden Strain.
Saif et al., Wooster, United States. In J Virol, 2014
UNLABELLED: The porcine sapovirus (SaV) (PoSaV) Cowden strain is one of only a few culturable enteric caliciviruses.
An emerging role for Hippo-YAP signaling in cardiovascular development.
Review
Zhou, Augusta, United States. In J Biomed Res, 2014
Recent studies demonstrate that cardiac-specific deletion of the Hippo pathway kinase Mst (STE20-like protein kinases) co-activator WW45 (WW domain-containing adaptor 45), Mst1, Mst2, or Lats2 (large tumor suppressor homologue 2) in mice result in over-grown hearts with elevated cardiomyocyte proliferation.
Spatial organization of Hippo signaling at the plasma membrane mediated by the tumor suppressor Merlin/NF2.
Impact
Pan et al., Baltimore, United States. In Cell, 2013
Membrane recruitment, in turn, promotes Wts phosphorylation by the Hpo-Sav kinase complex.
Salt-inducible kinases regulate growth through the Hippo signalling pathway in Drosophila.
Impact
Tapon et al., London, United Kingdom. In Nat Cell Biol, 2013
The pathway core is a kinase cassette, comprising the kinases Hpo and Warts (Wts) and the scaffold proteins Salvador (Sav) and Mats, which inactivates the pro-growth transcriptional co-activator Yorkie (Yki).
Protein kinases of the Hippo pathway: regulation and substrates.
Review
Barrufet et al., Boston, United States. In Semin Cell Dev Biol, 2012
In mammals, the Hippo orthologs Mst1 and Mst2 utilize the Salvador ortholog WW45/Sav1 and other scaffolds to regulate the kinases Lats1/Lats2 and ndr1/ndr2.
Screening of binding proteins that interact with human Salvador 1 in a human fetal liver cDNA library by the yeast two-hybrid system.
GeneRIF
Hu et al., Wuhan, China. In Mol Biol Rep, 2012
We also confirmed the interaction of HAX-1 and hSav1 in mammalian cells.
Mammalian ste20-like kinase and SAV1 promote 3T3-L1 adipocyte differentiation by activation of PPARγ.
GeneRIF
Lee et al., South Korea. In Plos One, 2011
Differentiation of 3T3-L1 cells was augmented by MST2 and SAV1 expression and inhibited by knockdown of MST1/2 or SAV1.
Tao-1 phosphorylates Hippo/MST kinases to regulate the Hippo-Salvador-Warts tumor suppressor pathway.
GeneRIF
Fehon et al., Chicago, United States. In Dev Cell, 2011
The Salvador pathway restrains tissue growth by phosphorylating and inactivating the oncoprotein Yorkie.
The sterile 20-like kinase Tao-1 controls tissue growth by regulating the Salvador-Warts-Hippo pathway.
GeneRIF
Harvey et al., Melbourne, Australia. In Dev Cell, 2011
The salvador protein pathway restrains tissue growth by phosphorylating and inactivating the oncoprotein Yorkie.
The Hippo pathway in biological control and cancer development.
Review
Hong et al., Singapore, Singapore. In J Cell Physiol, 2011
The core kinase components Hippo, Salvador, Warts, and Mats in the fly and Mst1/2, WW45, Lats1/2, and Mob1 in mammals phosphorylate and inactivate downstream transcriptional co-activators Yorkie in the fly, Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) in mammals, respectively.
Downregulation of SAV1 plays a role in pathogenesis of high-grade clear cell renal cell carcinoma.
GeneRIF
Moriyama et al., Ōita, Japan. In Bmc Cancer, 2010
downregulation of SAV1 and the consequent YAP1 activation are involved in the pathogenesis of high-grade clear cell renal cell carcinoma.
Function and frustration of multi-drug ABC exporter protein and design of model proteins for drug delivery using protein hydration thermodynamics.
Review
Zabel et al., Vestavia Hills, United States. In Curr Pharm Des, 2008
The mechanism is presented whereby simultaneous hydrolysis of two molecules of ATP in the ATP-binding cassette (ABC) exporter protein, Sav 1866, opens a transmembrane channel to pump drug out of the cell and confers drug resistance, e.g., gives rise to methicillin resistant Staphylococcus aureus, MRSA.
The emerging role of the hippo pathway in cell contact inhibition, organ size control, and cancer development in mammals.
Review
Impact
Hong et al., Singapore, Singapore. In Cancer Cell, 2008
The fly core components Hippo, Sav, Wts, and Mats are conserved in mammals as Mst1/2, WW45, LATS1/2, and Mob1.
The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila.
Impact
GeneRIF
Léopold et al., Nice, France. In Nat Cell Biol, 2003
data identify Hippo (Hpo) as a partner of Salvador (Sav), and suggest that Hpo and Sav function together to restrict tissue growth in vivo
Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway.
Impact
GeneRIF
Halder et al., Houston, United States. In Nat Cell Biol, 2003
Results suggest that Hippo acts together with Salvador and Warts in a signalling module that coordinately regulates cell proliferation and apoptosis.
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