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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Spermidine/spermine N1-acetyltransferase 1

SAT, SSAT, spermidine/spermine N1-acetyltransferase, spermidine/spermine N(1)-acetyltransferase
The protein encoded by this gene belongs to the acetyltransferase family, and is a rate-limiting enzyme in the catabolic pathway of polyamine metabolism. It catalyzes the acetylation of spermidine and spermine, and is involved in the regulation of the intracellular concentration of polyamines and their transport out of cells. Defects in this gene are associated with keratosis follicularis spinulosa decalvans (KFSD). Alternatively spliced transcripts have been found for this gene.[provided by RefSeq, Sep 2009] (from NCBI)
Top mentioned proteins: Insulin, HAD, fibrillin-1, CAN, AGE
Papers on SAT
Weight loss is associated with increased NAD(+)/SIRT1 expression but reduced PARP activity in white adipose tissue.
Pietiläinen et al., Helsinki, Finland. In J Clin Endocrinol Metab, Feb 2016
OBJECTIVE: We compared NAD(+)/SIRT pathway expressions and PARP activities in subcutaneous adipose tissue (SAT) between lean and obese subjects and investigated their change in the obese subjects during a 12-month weight loss.
Adipose tissue transcriptomics and epigenomics in low birthweight men and controls: role of high-fat overfeeding.
Ling et al., Copenhagen, Denmark. In Diabetologia, Feb 2016
We studied genome-wide mRNA expression and DNA methylation in subcutaneous adipose tissue (SAT) after 5 days of HFO and after a control diet in 40 young men, of whom 16 had LBW.
Sea cucumbers with an anti-inflammatory effect on endothelial cells and subcutaneous but not on epicardial adipose tissue.
Eiras et al., Santiago de Compostela, Spain. In Food Funct, Feb 2016
OBJECTIVE: epicardial adipose tissue (EAT) from patients with coronary artery disease (CAD) contains higher levels of inflammatory proteins and lower adiponectin levels than subcutaneous adipose tissue (SAT), enhancing the progression of atherosclerosis.
A role of the Inflammasome in the low storage capacity of the abdominal subcutaneous adipose tissue in obese adolescents.
Caprio et al., United States. In Diabetes, Jan 2016
Herein we tested the hypothesis that adipose tissue inflammation and NLRP3-inflammasome are linked to downregulation of subcutaneous adipose tissue (SAT) adipogenesis/lipogenesis in obese adolescents with altered abdominal fat partitioning.We performed abdominal subcutaneous adipose tissue biopsies on 58 obese adolescents and grouped them by MRI derived visceral to subcutaneous ratio (VAT/VAT+SAT) (cut-off 0.11).
Decreased sensitivity to aspirin is associated with altered polyamine metabolism in human prostate cancer cells.
Wallace et al., Aberdeen, United Kingdom. In Amino Acids, Jan 2016
In order to investigate the link between polyamine catabolism and the effects of aspirin we used a "Tet off" system that induced the activity of spermidine/spermine N (1)-acetyltransferase (SSAT) in human prostate cancer cells (LNCap).
Structure-Based Design of Inhibitors of the Crucial Cysteine Biosynthetic Pathway Enzyme O-Acetyl Serine Sulfhydrylase.
Gourinath et al., New Delhi, India. In Curr Top Med Chem, Dec 2015
Cysteine biosynthesis is catalysed by two enzymes: serine acetyl transferase (SAT) followed by O-acetylserine sulfhydrylase (OASS).
Unrecognized circulation of SAT 1 foot-and-mouth disease virus in cattle herds around Queen Elizabeth National Park in Uganda.
Tjørnehøj et al., Entebbe, Uganda. In Bmc Vet Res, Dec 2015
Within these 37 sera, antibody titres ≥ 80 against the structural proteins of serotypes O, SAT 1, SAT 2 and SAT 3 were detected by ELISA in 5, 7, 4 and 3 samples, respectively, while neutralizing antibodies were only detected against serotype O in 3 samples.
Subacute Thyroiditis
Hennessey, Madagascar. In Unknown Journal, May 2015
Subacute thyroiditis (SAT) is an inflammatory condition of the thyroid with characteristic presentations and clinical course.
Insulin resistance and impaired adipogenesis.
Smith et al., Göteborg, Sweden. In Trends Endocrinol Metab, Apr 2015
Subcutaneous adipose tissue (SAT) stores excess lipids through expansion of adipocytes (hypertrophic obesity) and/or recruitment of new precursor cells (hyperplastic obesity).
Control of adipocyte differentiation in different fat depots; implications for pathophysiology or therapy.
James et al., Sydney, Australia. In Front Endocrinol (lausanne), 2014
The largest depot, subcutaneous white fat [subcutaneous white adipose tissue (SAT)], has important beneficial characteristics including storage of lipid "out of harms way" and secretion of adipokines, especially leptin and adiponectin, with positive metabolic effects including lipid oxidation, energy utilization, enhanced insulin action, and an anti-inflammatory role.
The potential role of inhibitor of differentiation-3 in human adipose tissue remodeling and metabolic health.
Vestergaard et al., Copenhagen, Denmark. In Mol Genet Metab, 2014
Metabolic health in obesity is known to differ among individuals, and the distribution of visceral (VAT) and subcutaneous adipose tissue (SAT) plays an important role in this regard.
Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity.
Kahn et al., Boston, United States. In Nature, 2014
Polyamine flux including synthesis, catabolism and excretion, is controlled by the rate-limiting enzymes ornithine decarboxylase (ODC) and spermidine-spermine N(1)-acetyltransferase (SSAT; encoded by Sat1) and by polyamine oxidase (PAO), and has a major role in energy metabolism.
MyomiR-133 regulates brown fat differentiation through Prdm16.
Stoffel et al., Zürich, Switzerland. In Nat Cell Biol, 2012
Here we show that after cold exposure, the muscle-enriched miRNA-133 is markedly downregulated in BAT and subcutaneous white adipose tissue (SAT) as a result of decreased expression of its transcriptional regulator Mef2.
Overexpression of SSAT by DENSPM treatment induces cell detachment and apoptosis in glioblastoma.
Zhang et al., Tianjin, China. In Oncol Rep, 2012
SSAT induction plays a role in cell detachment and apoptosis of glioblastoma cells by N1,N11-diethylnorspermine treatment.
Polyamine-regulated translation of spermidine/spermine-N1-acetyltransferase.
Merali et al., Philadelphia, United States. In Mol Cell Biol, 2012
SSAT translational control mechanisms
Lipopolysaccharide-induced anti-inflammatory acute phase response is enhanced in spermidine/spermine N1-acetyltransferase (SSAT) overexpressing mice.
Uimari et al., Kuopio, Finland. In Amino Acids, 2012
study suggests that SSAT overexpression obtained in SSAT mice enhances the anti-inflammatory actions in the acute phase of LPS-induced immune response
Epigenetic regulation of spermidine/spermine N1-acetyltransferase (SAT1) in suicide.
Turecki et al., Montréal, Canada. In J Psychiatr Res, 2011
The results of this study indicated that epigenetic factors in the promoter region of SAT1 influence gene expression levels, and may provide a mechanism for both our previous findings of haplotype-specific effects of promoter variations on SAT1 expression
Association of polyaminergic loci with anxiety, mood disorders, and attempted suicide.
Turecki et al., Montréal, Canada. In Plos One, 2009
Studies indicate that each of the 4 genes was associated with at least one main outcome: anxiety (SAT1, SMS), mood disorders (SAT1, SMOX), and suicide attempts (SAT1, OATL1).
DNA computing on surfaces.
Smith et al., Madison, United States. In Nature, 2000
We consider a small example of the satisfiability problem (SAT), in which the values of a set of boolean variables satisfying certain logical constraints are determined.
Melting of H2SO4·4H2O Particles upon Cooling: Implications for Polar Stratospheric Clouds
Carslaw et al., Mainz, Germany. In Science, 1996
Solid PSCs can form on sulfuric acid tetrahydrate (SAT) (H2SO4·4H2O) nuclei, but recent laboratory experiments have shown that PSC nucleation on SAT is strongly hindered.
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