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Squamous cell carcinoma antigen recognized by T cells

SART1
This gene encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. The SART1(259) protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation; its full-length sequence is not published yet. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens. The SART1(259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1(259) antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1(259) protein is found to be essential for the recruitment of the tri-snRNP to the pre-spliceosome in the spliceosome assembly pathway. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, ACID, fibrillin-1, OUT, Ubiquitin
Papers on SART1
The spliceosome factor SART1 exerts its anti-HCV action through mRNA splicing.
New
Chung et al., Boston, United States. In J Hepatol, May 2015
We previously identified SART1, a host protein involved in RNA splicing and pre-mRNA processing, as a regulator of IFN's antiviral effects.
Mutant versions of von Hippel-Lindau (VHL) can protect HIF1α from SART1-mediated degradation in clear-cell renal cell carcinoma.
New
Landazuri et al., Madrid, Spain. In Oncogene, May 2015
This reduction of HIF1α protein is due to proteasome-dependent degradation and is mediated by the E3 ubiquitin ligase SART1.
Immune responses in patients with esophageal cancer treated with SART1 peptide-pulsed dendritic cell vaccine.
New
Takahashi et al., Niigata, Japan. In Int J Oncol, Apr 2015
In order to explore the feasibility and effectiveness of dendritic cell (DC)-based immunotherapy for squamous cell carcinoma of esophagus, we performed a phase I/II clinical trial of monocyte-derived dendritic cells (moDCs) pulsed with SART1 peptide in seven patients with advanced stage of this disease.
Multiple components of the spliceosome regulate Mcl1 activity in neuroblastoma.
Hogarty et al., Philadelphia, United States. In Cell Death Dis, 2013
The latter two are members of a recently characterized subcomplex of the spliceosome that along with SART1 is responsible for non-canonical 5'-splice sequence recognition in yeast.
In vitro induction of specific CD8+ T lymphocytes by tumor-associated antigenic peptides in patients with oral squamous cell carcinoma.
Nakamura et al., Fukuoka, Japan. In Cancer Lett, 2012
The potent peptides were SART-1(690) in 9/35 (25.7%),
A functional genomic screen reveals novel host genes that mediate interferon-alpha's effects against hepatitis C virus.
Chung et al., Beijing, China. In J Hepatol, 2012
We confirmed that silencing squamous cell carcinoma antigen recognized by T cells (SART1), a specific factor of tri-snRNP, abrogates IFN-α's suppressive effects against HCV in both replicon cells and JFH1 infectious cells.
A systems biology approach identifies SART1 as a novel determinant of both 5-fluorouracil and SN38 drug resistance in colorectal cancer.
GeneRIF
Johnston et al., Ireland. In Mol Cancer Ther, 2012
This study identifies SART1 as a previously unidentified regulator of c-FLIP and drug-induced activation of caspase-8.
Identification of novel SNPs in glioblastoma using targeted resequencing.
Meese et al., Heidelberg, Germany. In Plos One, 2010
Particularly, the breast cancer associated allele of rs660118 SNP in the gene SART1 showed a near doubled frequency in glioblastoma patients, as verified in an independent control cohort by Sanger sequencing.
Positively charged amino acids flanking a sumoylation consensus tetramer on the 110kDa tri-snRNP component SART1 enhance sumoylation efficiency.
Vertegaal et al., Leiden, Netherlands. In J Proteomics, 2010
Previously, we have identified the 110kDa U4/U6.U5 tri-snRNP component SART1 as a target protein for SUMO-1 and SUMO-2.
Variation in genes required for normal mitosis and risk of breast cancer.
Couch et al., Rochester, United States. In Breast Cancer Res Treat, 2010
Two variants in EIF3A (rs10787899 and rs3824830; P < 0.01) and four variants in SART1 (rs660118, rs679581, rs754532, and rs735942; P(trend) < or = 0.02) were significantly associated with an altered risk of breast cancer along with single variants in RRM2, PSCD3, C11orf51, CDC16, SNW1, MFAP1, and CDC2 (P < 0.05).
Induction of antigen-specific cytotoxic T lymphocytes by using monocyte-derived DCs transfected with in vitro-transcribed WT1 or SART1 mRNA.
Takahashi et al., Niigata, Japan. In Med Oncol, 2009
These findings revealed that monocyte-derived dendritic cells transfected with WT1 or SART1 mRNA are able to induce tumor antigen-specific cytotoxic T cells and applicable for antitumor dendritic cell-based cellular immunotherapy.
The telomere-specific non-LTR retrotransposons SART1 and TRAS1 are suppressed by Piwi subfamily proteins in the silkworm, Bombyx mori.
Kusakabe et al., Fukuoka, Japan. In Cell Mol Biol Lett, 2009
Here, we report that the transcription of the telomeric retroelements SART1 and TRAS1 is suppressed by the silkworm Piwi subfamily proteins BmAgo3 and Siwi.
Expression of SART-1 mRNA in canine squamous cell carcinomas.
Orima et al., Japan. In J Vet Med Sci, 2008
SART-1, a squamous cell carcinoma (SCC) antigen recognized by cytotoxic T lymphocytes, has been useful in human cancer therapy.
Hypoxia-associated factor, a novel E3-ubiquitin ligase, binds and ubiquitinates hypoxia-inducible factor 1alpha, leading to its oxygen-independent degradation.
GeneRIF
Powis et al., Houston, United States. In Mol Cell Biol, 2008
hypoxia-associated factor (HAF), also known as SART1, a protein expressed in proliferating cells, binds and ubiquitinates HIF-1alpha in vitro, and both binding and E3 ligase activity are mediated by HAF amino acids 654 to 800
[Cytogenetics and application in domesticated silkworm Bombyx mori].
Review
Huang et al., Chengdu, China. In Yi Chuan, 2006
Molecular and cytogenetics will help us to reveal the structure and function of chromosome of Bombyx mori, the W chromosome is composed largely of dense nested retrotransposons, and telomeres are consist of the TTAGG motifs and two type of telomere-specific non-LTR retrotransposons (TRAS1 and SART1), the TRAS1 and SART1 with abundant transcription activity may be involved in the stabilization of chromosomal ends.
Identification of the autoantigen SART-1 as a candidate gene for the development of atopy.
GeneRIF
Hall et al., Nottingham, United Kingdom. In Hum Mol Genet, 2002
hypothesize that polymorphic variation within the SART-1 gene may account for individuals developing atopy
p110, a novel human U6 snRNP protein and U4/U6 snRNP recycling factor.
GeneRIF
Bindereif et al., Gießen, Germany. In Embo J, 2002
p110, a novel human U6 snRNP protein and U4/U6 snRNP recycling factor
[Specific immunotherapy with cancer vaccines].
Review
Itoh et al., Kurume, Japan. In Gan To Kagaku Ryoho, 2000
Using CTLs, we identified a new gene SART-1 by cDNA-expression cloning and some SART-1-derived cancer rejection peptides were also identified.
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