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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Ankyrin repeat domain 42

SARP
Top mentioned proteins: CAN, V1a, ACID, HAD, POLYMERASE
Papers on SARP
Characterisation of the genes involved in the biosynthesis and attachment of the aminodeoxysugar D-forosamine in the auricin gene cluster of Streptomyces aureofaciens CCM3239.
New
Kormanec et al., Bratislava, Slovakia. In Appl Microbiol Biotechnol, Jan 2016
The expression of the other D-forosamine genes, however, is governed by promoters differentially dependent upon the two SARP family auricin-specific activators Aur1PR3 and Aur1PR4.
Constitutive overexpression of asm18 increases the production and diversity of maytansinoids in Actinosynnema pretiosum.
New
Shen et al., Jinan, China. In Appl Microbiol Biotechnol, Dec 2015
In this study, we investigated the function of a pathway-specific S treptomyces antibiotic regulatory protein (SARP) family regulator, Asm18, and observed that ectopic overexpression of the asm18 gene increased the production of N-demethyl-4,5-desepoxy-maytansinol (2) to 50 mg/L in the HGF052 + pJTU824-asm18 strain, an increase by 4.7-fold compared to that of the control strain HGF052 + pJTU824.
Overproduction of lactimidomycin by cross-overexpression of genes encoding Streptomyces antibiotic regulatory proteins.
New
Shen et al., Harbin, China. In Appl Microbiol Biotechnol, Dec 2015
These results support MgsA and ChxA as members of the SARP family of positive regulators for the iso-MGS and CHX biosynthetic machinery and demonstrate the feasibility to improve glutarimide-containing polyketide production in Streptomyces strains by exploiting common regulators.
A Complex Signaling Cascade Governs Pristinamycin Biosynthesis in Streptomyces pristinaespiralis.
New
Schinko et al., Tübingen, Germany. In Appl Environ Microbiol, Oct 2015
A γ-butyrolactone receptor gene (spbR), two TetR repressor genes (papR3 and papR5), three SARP (Streptomyces antibiotic regulatory protein) genes (papR1, papR2, and papR4), and a response regulator gene (papR6) are carried on the large 210-kb pristinamycin biosynthetic gene region of Streptomyces pristinaespiralis Pr11.
The SARP Family Regulator Txn9 and Two-Component Response Regulator Txn11 are Key Activators for Trioxacarcin Biosynthesis in Streptomyces bottropensis.
New
Yuan et al., Shanghai, China. In Curr Microbiol, Oct 2015
Trioxacarcin A is a polyoxygenated, structurally complex antibiotic produced by Streptomyces spp., which possesses high anti-bacterial, anti-malaria, and anti-tumor activities.
Functional characterization of different ORFs including luciferase-like monooxygenase genes from the mensacarcin gene cluster.
New
Bechthold et al., Freiburg, Germany. In Chembiochem, Jun 2015
Analysis of the metabolic profiles of the mutant strains showed the complete collapse of DDMM biosynthesis, but upon overexpression of the SARP regulatory gene msnR1 in each mutant new intermediates were detected.
Transcriptional regulation of mithramycin biosynthesis in Streptomyces argillaceus: dual role as activator and repressor of the PadR-like regulator MtrY.
New
Méndez et al., In Microbiology, Feb 2015
The mithramycin biosynthesis gene cluster of Streptomyces argillaceus ATCC 12956 contains 34 ORFs and includes two putative regulatory genes (mtmR and mtrY), which encode proteins of the SARP (Streptomyces antibiotic regulatory protein) and PadR transcriptional regulator families, respectively.
Gene expression in relation to exhaled nitric oxide identifies novel asthma phenotypes with unique biomolecular pathways.
Wenzel et al., Pittsburgh, United States. In Am J Respir Crit Care Med, 2015
METHODS: We used a microarray platform to analyze bronchial airway epithelial cell gene expression in relation to the asthma biomarker fractional exhaled nitric oxide (FeNO) in 155 subjects with asthma and healthy control subjects from the Severe Asthma Research Program (SARP).
Differential contributions of two SARP family regulatory genes to indigoidine biosynthesis in Streptomyces lavendulae FRI-5.
Nihira et al., Suita, Japan. In Appl Microbiol Biotechnol, 2014
The Streptomyces antibiotic regulatory protein (SARP) family regulators have been shown to control the production of secondary metabolites in many Streptomyces species as the most downstream regulators in the regulatory cascade.
Identification of a cluster-situated activator of oxytetracycline biosynthesis and manipulation of its expression for improved oxytetracycline production in Streptomyces rimosus.
Yang et al., Beijing, China. In Microb Cell Fact, 2014
RESULTS: A gene encoding a Streptomyces antibiotic regulatory protein (SARP) was discovered immediately adjacent to the otrB gene of oxy cluster in S. rimosus and designated otcR.
The gamma-butyrolactone receptors BulR1 and BulR2 of Streptomyces tsukubaensis: tacrolimus (FK506) and butyrolactone synthetases production control.
Martín et al., León, Spain. In Appl Microbiol Biotechnol, 2014
This region contains ten genes (bulA, bulZ, bulY, bulR2, bulS2, bulR1, bulW, bluB, bulS1, bulC) including two γ-butyrolactone receptor homologues (bulR1, bulR2), two putative gamma-butyrolactone synthetase homologues (bulS1, bulS2) and two SARP regulatory genes (bulY, bulZ).
A gene determining a new member of the SARP family contributes to transcription of genes for the synthesis of the angucycline polyketide auricin in Streptomyces aureofaciens CCM 3239.
Kormanec et al., Bratislava, Slovakia. In Fems Microbiol Lett, 2013
Three regulators, Aur1P, Aur1R and a SARP-family Aur1PR3, have been previously found to control expression of the aur1 cluster for the angucycline antibiotic auricin in Streptomyces aureofaciens CCM 3239.
SARP: A Novel Algorithm to Assess Compositional Biases in Protein Sequences.
Nizhnikov et al., Saint Petersburg, Russia. In Evol Bioinform Online, 2012
Here, we present a Sequence Analysis based on the Ranking of Probabilities (SARP), a novel algorithm for the annotation of compositional biases based on ranking subsequences by their probabilities.
Engineering of regulatory cascades and networks controlling antibiotic biosynthesis in Streptomyces.
Review
Liras et al., León, Spain. In Curr Opin Microbiol, 2010
Two types of regulatory mechanisms have been studied in Streptomyces species: (1) pyramidal cascades of regulation that usually involve a butyrolactone and its receptor protein triggering the formation of pathway-associated regulatory proteins (SARP), and (2) global regulators that transduce protein phosphorylation signals responding to stress factors.
SARP, a new alternatively spliced protein phosphatase 1 and DNA interacting protein.
GeneRIF
da Cruz E Silva et al., Dundee, United Kingdom. In Biochem J, 2007
the cloning and characterization of a new protein, termed SARP (several ankyrin repeat protein), which is shown to interact with all isoforms of PP1 by a variety of techniques.
[Regulation of antibiotic biosynthesis in Streptomycetes].
Review
Matseliukh, In Mikrobiol Z, 2006
The first regulatory level is presented by related proteins of SARP family playing the role of positive transcription factors of pathway-specific genes of clusters of antibiotic biosynthesis.
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