Toll/interleukin-1 receptor (TIR) domain-mediated cellular signaling pathways.
Kyŏngsan, South Korea. In Apoptosis, Feb 2015
The Toll-like receptor/Interleukin (IL)-1 receptor (TLR/IL-1R) superfamily comprises proteins that contain the phylogenetically conserved Toll/IL-1 receptor (TIR) domain, which is responsible for the propagation of downstream signaling through recruitment of TIR domain containing cytosolic adaptor proteins such as MyD88, TIRAP/MAL, TRIF, TRAM and SARM.
dSarm/Sarm1 is required for activation of an injury-induced axon death pathway.
Worcester, United States. In Science, 2012
severed mouse Sarm1 null axons exhibit long-term survival both in vivo and in vitro, indicating Sarm1 prodegenerative signaling is conserved in mammals; results provide direct evidence that axons actively promote their own destruction after injury and identify dSarm/Sarm1 as a member of an ancient axon death signaling pathway