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Creatine kinase, mitochondrial 2

sarcomeric mitochondrial creatine kinase, sMtCK, CKMT2
Mitochondrial creatine kinase (MtCK) is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Sarcomeric mitochondrial creatine kinase has 80% homology with the coding exons of ubiquitous mitochondrial creatine kinase. This gene contains sequences homologous to several motifs that are shared among some nuclear genes encoding mitochondrial proteins and thus may be essential for the coordinated activation of these genes during mitochondrial biogenesis. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Papers on sarcomeric mitochondrial creatine kinase
Acyl chain composition determines cardiolipin clustering induced by mitochondrial creatine kinase binding to monolayers.
Granjon et al., Villeurbanne, France. In Biochim Biophys Acta, 2011
Data show that mtCK-cardiolipin domains were observed not only with unsaturated cardiolipins, but also with the cardiolipin precursor phosphatidylglycerol.
Protein kinase CK2alpha as an unfavorable prognostic marker and novel therapeutic target in acute myeloid leukemia.
Min et al., Seoul, South Korea. In Clin Cancer Res, 2007
CK2alpha has a role in progression of acute myeloid leukemia
Functional coupling of adenine nucleotide translocase and mitochondrial creatine kinase is enhanced after exercise training in lung transplant skeletal muscle.
Pison et al., Grenoble, France. In Am J Physiol Regul Integr Comp Physiol, 2005
After the training period, intracellular energetic units had a higher control of mitochondrial respiration by creatine linked to a more efficient functional coupling adenine nucleotide translocase-mitochondrial creatine kinase.
C-terminal lysines determine phospholipid interaction of sarcomeric mitochondrial creatine kinase.
Wallimann et al., Z├╝rich, Switzerland. In J Biol Chem, 2004
three C-terminal lysines determine high affinity sMtCK/cardiolipin interaction and its effects on MtCK structure, whereas low level binding and some effect on membrane fluidity depend on other structural components
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