gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

IQ motif containing GTPase activating protein 1

Sar1, guanylin, SARA, IQGAP1, GAP1
This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, Actin, V1a, ACID, HAD
Papers using Sar1 antibodies
A molecular mechanism directly linking E-cadherin adhesion to initiation of epithelial cell surface polarity
Menke Andre et al., In Cell Communication and Signaling : CCS, 2006
... IQGAP1 protein expression was inhibited by specific double-stranded siRNAs (Qiagen), designed by using Qiagen ...
PI(4,5)P2-dependent microdomain assemblies capture microtubules to promote and control leading edge motility
Caroni Pico et al., In The Journal of Cell Biology, 2002
... Antibodies and fluorescent reagents were purchased from the following sources: FLAG, anti-vinculin (Sigma-Aldrich); Arp3, IQGAP1 (Santa Cruz Biotechnology, Inc.); cortactin (Upstate Biotechnology); ...
Papers on Sar1
Obesity-Induced Colorectal Cancer Is Driven by Caloric Silencing of the Guanylin-GUCY2C Paracrine Signaling Axis.
Waldman et al., Philadelphia, United States. In Cancer Res, Feb 2016
During colon cancer development in humans or animals, attenuation of the colonic cell surface receptor guanylyl cyclase C (GUCY2C) that occurs due to loss of its paracrine hormone ligand guanylin contributes universally to malignant progression.
FGF-2 inhibits Endothelial-Mesenchymal Transition through microRNA-20a-mediated repression of canonical TGF-β Signaling.
Krenning et al., Groningen, Netherlands. In J Cell Sci, Feb 2016
We identified ALK5, TGFBR2 and SARA as direct miR-20a targets.
Noncanonical Activin A Signaling in PC12 Cells: A Self-Limiting Feedback Loop.
Xu et al., Changchun, China. In Neurochem Res, Jan 2016
This periodic behavior of Act A signal loop was found to be regulated by the level of Smad anchor for receptor activation (SARA).
Polarized endosome dynamics by spindle asymmetry during asymmetric cell division.
Gonzalez-Gaitan et al., Genève, Switzerland. In Nature, Jan 2016
It has recently been shown that Sara (Smad anchor for receptor activation) signalling endosomes in the cytoplasm also segregate asymmetrically during asymmetric division.
IQGAP1 is a phosphoinositide effector and kinase scaffold.
Anderson et al., Madison, United States. In Adv Biol Regul, Nov 2015
IQGAP1 is newly identified as an interactor of multiple isoforms of PIPKs.
A systematic review of known mechanisms of hydroxyurea-induced fetal hemoglobin for treatment of sickle cell disease.
Wonkam et al., Cape Town, South Africa. In Expert Rev Hematol, Oct 2015
RESULTS: Studies have provided consistent associations between genomic variations in HbF-promoting loci and variable HbF level in response to HU. Numerous signal transduction pathways have been implicated, through the identification of key genomic variants in BCL11A, HBS1L-MYB, SAR1 or XmnI polymorphism that predispose the response to the treatment, and signal transduction pathways that modulate γ-globin expression (cAMP/cGMP; Giα/c-Jun N-terminal kinase/Jun; methylation and miRNA).
[Research Progress in the Core Proteins of the Classical Swine Fever Virus].
Zhang et al., In Bing Du Xue Bao, Sep 2015
In this review, we combine study of this protein with its disorders, structural/functional characteristics, as well as its interactions with the non-structural proteins NS3, NS5B and host proteins such as SUMO-1, UBC9, OS9 and IQGAP1.
Pathophysiological evaluation of subacute ruminal acidosis (SARA) by continuous ruminal pH monitoring.
Sato, Morioka, Japan. In Anim Sci J, Sep 2015
UNASSIGNED: Evaluation of the radio-transmission pH-measurement system for monitoring the ruminal pH and subacute ruminal acidosis (SARA) in cattle is described.
Directional Notch trafficking in Sara endosomes during asymmetric cell division in the spinal cord.
González-Gaitán et al., Genève, Switzerland. In Nat Cell Biol, Mar 2015
Here we show that, during mitosis of neural precursors in zebrafish, directional trafficking of Sara endosomes to one of the daughters can function as such a determinant.
Biological and clinical characteristics of the European Friedreich's Ataxia Consortium for Translational Studies (EFACTS) cohort: a cross-sectional analysis of baseline data.
Schulz et al., Aachen, Germany. In Lancet Neurol, Feb 2015
The primary outcome measure was the Scale for the Assessment and Rating of Ataxia (SARA) and secondary outcome measures were the Inventory of Non-Ataxia Signs (INAS), the performance-based coordination test Spinocerebellar Ataxia Functional Index (SCAFI), the neurocognitive phonemic verbal fluency test, and two quality-of-life measures: the activities of daily living (ADL) part of the Friedreich's Ataxia Rating Scale and EQ-5D.
IQGAPs as Key Regulators of Actin-cytoskeleton Dynamics.
Kaibuchi et al., Nagoya, Japan. In Cell Struct Funct, 2014
The actin-binding protein IQGAP1 was identified as an effector of Rac and Cdc42 and is the founding member of the IQGAP family with two additional isoforms.
Effect of NaCl on Biofilm Formation of the Isolate from Staphylococcus aureus Outbreak Linked to Ham.
Yoon et al., Seoul, South Korea. In Korean J Food Sci Anim Resour, 2013
The transcriptional analysis of biofilm-related genes, such as icaA, atl, clfA, fnbA, sarA, and rbf, was conducted by quantitative real-time PCR.
Mind the IQGAP.
Marais et al., Manchester, United Kingdom. In Cancer Cell, 2013
The scaffold protein IQGAP1 regulates cell signaling through the RAF/MEK/ERK pathway.
IQGAP1 scaffold-kinase interaction blockade selectively targets RAS-MAP kinase-driven tumors.
Khavari et al., Stanford, United States. In Nat Med, 2013
MAPK scaffolds, such as IQ motif-containing GTPase activating protein 1 (IQGAP1), assemble pathway kinases to affect signal transmission, and disrupting scaffold function therefore offers an orthogonal approach to MAPK cascade inhibition.
Sedlin controls the ER export of procollagen by regulating the Sar1 cycle.
De Matteis et al., Napoli, Italy. In Science, 2012
Sedlin bound and promoted efficient cycling of Sar1, a guanosine triphosphatase that can constrict membranes, and thus allowed nascent carriers to grow and incorporate procollagen prefibrils.
IQGAP1 is necessary for pulmonary vascular barrier protection in murine acute lung injury and pneumonia.
Sheppard et al., San Francisco, United States. In Am J Physiol Lung Cell Mol Physiol, 2012
IQGAP1 localized to the endothelial cell-cell junction after sphingosine-1-phosphate (S1P) treatment.
The cytoskeletal adaptor protein IQGAP1 regulates TCR-mediated signaling and filamentous actin dynamics.
Billadeau et al., Rochester, United States. In J Immunol, 2012
our data suggest that IQGAP1 acts as a dual negative regulator in T cells, limiting both TCR-mediated activation kinetics and F-actin dynamics via distinct mechanisms.
Retinal guanylyl cyclase isozyme 1 is the preferential in vivo target for constitutively active GCAP1 mutants causing congenital degeneration of photoreceptors.
Dizhoor et al., United States. In J Neurosci, 2012
results argue that there must be a cellular mechanism that limits GCAP1 access to RetGC2 and makes RetGC1 isozyme a preferential target for the disease-causing GCAP1 mutants.
The murine Gcap14 gene encodes a novel microtubule binding and bundling protein.
Nadano et al., Nagoya, Japan. In Febs Lett, 2012
Recombinant Gcap14 protein cosedimented with pure microtubules, indicating a direct binding between the two
share on facebooktweetadd +1mail to friends