Pharmacology of bile acid receptors: Evolution of bile acids from simple detergents to complex signaling molecules.
East Lansing, United States. In Pharmacol Res, Jan 2016
Ultimately, seminal studies by many investigators led to the discovery of several bile acid-activated receptors including the farnesoid X receptor, the vitamin D receptor, the pregnane X receptor, TGR5, α5 β1 integrin, and sphingosine-1-phosphate receptor 2. Several of these receptors are expressed outside of the gastrointestinal system, indicating that bile acids may have diverse functions throughout the body.
Imidazoquinolines: Recent developments in anticancer activity.
North Chicago, United States. In Mini Rev Med Chem, Jan 2016
This article reviews briefly the synthesis, structure-activity relationship (SAR) and biological activities of clinically studied imidazoquinolines along with novel emerging preclinical imidazoquinolines for the anticancer activity.
Bile acid signaling in metabolic disease and drug therapy.
Tokelau. In Pharmacol Rev, 2014
The bile acid-activated nuclear receptors farnesoid X receptor, pregnane X receptor, constitutive androstane receptor, vitamin D receptor, and G protein-coupled bile acid receptor play critical roles in the regulation of lipid, glucose, and energy metabolism, inflammation, and drug metabolism and detoxification.