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Protein phosphatase 6, regulatory subunit 1

Saps1, PP6R1
Protein phosphatase regulatory subunits, such as SAPS1, modulate the activity of protein phosphatase catalytic subunits by restricting substrate specificity, recruiting substrates, and determining the intracellular localization of the holoenzyme. SAPS1 is a regulatory subunit for the protein phosphatase-6 catalytic subunit (PPP6C; MIM 612725) (Stefansson and Brautigan, 2006 [PubMed 16769727]).[supplied by OMIM, Nov 2010] (from NCBI)
Top mentioned proteins: Saps, LNP, PP6, SAPS2, SAP
Papers on Saps1
PP6 regulatory subunit R1 is bidentate anchor for targeting protein phosphatase-6 to DNA-dependent protein kinase.
Larner et al., Charlottesville, United States. In J Biol Chem, 2012
PP6 regulatory subunit R1 is bidentate anchor for targeting protein phosphatase-6 to DNA-dependent protein kinase.
Protein phosphatase 6 interacts with the DNA-dependent protein kinase catalytic subunit and dephosphorylates gamma-H2AX.
Lees-Miller et al., Calgary, Canada. In Mol Cell Biol, 2010
Here we report that DNA-PKcs interacts with the catalytic subunits of PP6 (PP6c) and PP2A (PP2Ac), as well as with the PP6 regulatory subunits PP6R1, PP6R2, and PP6R3.
Activation of DNA-PK by ionizing radiation is mediated by protein phosphatase 6.
Larner et al., Charlottesville, United States. In Plos One, 2008
Mass spectrometry analysis revealed that DNA-PK interacts with the protein phosphatase-6 (PP6) SAPS subunit PP6R1.
Human protein phosphatase PP6 regulatory subunits provide Sit4-dependent and rapamycin-sensitive sap function in Saccharomyces cerevisiae.
Cardenas et al., Durham, United States. In Plos One, 2008
In the budding yeast Saccharomyces cerevisiae the protein phosphatase Sit4 and four associated proteins (Sap4, Sap155, Sap185, and Sap190) mediate G(1) to S cell cycle progression and a number of signaling events controlled by the target of rapamycin TOR signaling cascade.
Promiscuous T cell epitope prediction of Candida albicans secretory aspartyl protienase family of proteins.
Chaiyaroj et al., Bangkok, Thailand. In Infect Genet Evol, 2008
Analysis of Saps1-10 protein entries from CandiVF database revealed that a consensus T cell epitope was located at the C-terminal region of Saps1-10.
Gene expression ratio stability evaluation in prepubertal bovine mammary tissue from calves fed different milk replacers reveals novel internal controls for quantitative polymerase chain reaction.
Loor et al., Urbana, United States. In J Nutr, 2008
Genes evaluated were ubiquitously expressed transcript, protein phosphatase 1 regulatory (inhibitor) subunit 11 (PPP1R11), matrix metallopeptidase 14 (MMP14), ClpB caseinolytic peptidase B, SAPS domain family member 1 (SAPS1), mitochondrial GTPase 1 (MTG1), mitochondrial ribosomal protein L39, ribosomal protein S15a (RPS15A), and actin beta (ACTB).
Protein phosphatase 6 regulatory subunits composed of ankyrin repeat domains.
Brautigan et al., Charlottesville, United States. In Biochemistry, 2008
This study used a human SAPS domain subunit FLAG-PP6R1 to identify endogenous interacting proteins.
Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IkappaBepsilon.
Brautigan et al., Charlottesville, United States. In J Biol Chem, 2006
Northern hybridization showed differential distribution of the human SAPS-related mRNA in multiple human tissues, named as PP6R1, PP6R2, and PP6R3.
Individual acid aspartic proteinases (Saps) 1-6 of Candida albicans are not essential for invasion and colonization of the gastrointestinal tract in mice.
Nichterlein et al., Mannheim, Germany. In Microb Pathog, 2002
Also with immunoelectron microscopy we demonstrated production of Saps1-3 as well as Saps4-6 with antibodies cross-reacting with either Saps1-3 or Saps4-6.
Accuracy of a composite score using daily SAPS II and LOD scores for predicting hospital mortality in ICU patients hospitalized for more than 72 h.
Cohen et al., Paris, France. In Intensive Care Med, 2001
MEASUREMENTS AND MAIN RESULTS: The LOD and SAPS II scores were calculated during the first (SAPS1, LOD1), second (SAPS2, LOD2), and third (SAPS3, LOD3) calendar days.
Multicentric study of monitoring alarms in the adult intensive care unit (ICU): a descriptive analysis.
Boniface et al., Lille, France. In Intensive Care Med, 1999
MEASUREMENTS AND MAIN RESULTS: The mean age of the patients included was 59.8 +/- 16.4 and SAPS1 was 15.9 +/- 7.4.
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