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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Src kinase associated phosphoprotein 2

Saps, SKAP-HOM, SKAP55R
The protein encoded by this gene belongs to the src family kinases. This protein is similar to the src kinase associated phosphoprotein 1. It is an adaptor protein that is thought to play an essential role in the src signaling pathway in various cells. It inhibits PTK2B/RAFTK activity and regulates alpha-synuclein phosphorylation. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: SAP, CAN, SAP1, HAD, ACID
Papers on Saps
Two SAPP2 gene homologs are present in Candida parapsilosis genome.
New
Hrušková-Heidingsfeldová et al., Praha, Czech Republic. In Folia Microbiol (praha), Sep 2015
Candida parapsilosis produces secreted aspartic proteinases (Saps), which contribute to the virulence of this opportunistic pathogen.
Novel Aggregation Properties of Candida albicans Secreted Aspartyl Proteinase Sap6 Mediate Virulence in Oral Candidiasis.
New
Edgerton et al., In Infect Immun, Jul 2015
Secreted aspartic proteinases (Saps) are a family of 10 related proteases and are virulence factors due to their proteolytic activity, as well as their roles in adherence and colonization of host tissues.
Induction of caspase-11 by aspartyl proteinases of Candida albicans and implication in promoting inflammatory response.
New
Vecchiarelli et al., Perugia, Italy. In Infect Immun, May 2015
We recently demonstrated that the secreted aspartyl proteinases (Saps), Sap2 and Sap6, of Candida albicans have the potential to induce the canonical activation of the NLRP3 inflammasome, leading to the secretion of interleukin-1β (IL-1β) and IL-18 via caspase-1 activation.
Role of SAP7-10 and Morphological Regulators (EFG1, CPH1) in Candida albicans' Hypha Formation and Adhesion to Colorectal Carcinoma Caco-2.
Chudy et al., In Pol J Microbiol, 2014
Secreted aspartic proteases (Saps) are considered as key virulence factors of Candida albicans.
Kinin release from human kininogen by 10 aspartic proteases produced by pathogenic yeast Candida albicans.
Rapala-Kozik et al., Kraków, Poland. In Bmc Microbiol, 2014
BACKGROUND: Candida albicans yeast produces 10 distinct secreted aspartic proteases (Saps), which are some of the most important virulence factors of this pathogenic fungus.
Candida albicans Shed Msb2 and Host Mucins Affect the Candidacidal Activity of Salivary Hst 5.
Edgerton et al., Buffalo, United States. In Pathogens, 2014
Proteins secreted by C. albicans during infection such as secreted aspartyl proteases (Saps) and shed mucin Msb2 can reduce Hst 5 activity; and human salivary mucins, while suggested to protect Hst 5 from proteolytic degradation, can entrap peptides into mucin gels, thereby reducing bioavailability.
Genetic variability of Candida albicans Sap8 propeptide in isolates from different types of infection.
Sampaio et al., Braga, Portugal. In Biomed Res Int, 2014
The secreted aspartic proteases (Saps) are among the most studied virulence determinants in Candida albicans.
Hippocampus-dependent learning in SKAP-HOM deficient mice.
Becker et al., Magdeburg, Germany. In Behav Brain Res, 2014
SKAP-HOM is an adapter protein which regulates the cross-talk between immunoreceptors and integrins and is involved in signal transduction.
Role of Candida albicans-secreted aspartyl proteinases (Saps) in severe early childhood caries.
Zhao et al., Guangzhou, China. In Int J Mol Sci, 2013
However, the roles of secreted aspartyl proteinases (Saps), an important virulence factor of C. albicans, in the progress of S-ECC are not clear.
Aspartic protease inhibitors: effective drugs against the human fungal pathogen Candida albicans.
Review
Braga-Silva et al., Rio de Janeiro, Brazil. In Mini Rev Med Chem, 2013
There is no doubt that the secretion of aspartic proteases, designated as Saps, is one of the major virulence attributes produced by C. albicans cells, since these hydrolytic enzymes participate in a wide range of fungal physiological processes as well as in different facets of the fungal-host interactions.
Sap6, a secreted aspartyl proteinase, participates in maintenance the cell surface integrity of Candida albicans.
Chen et al., Kao-hsiung, Taiwan. In J Biomed Sci, 2012
The secreted aspartyl proteinases (Saps) of C. albicans, encoded by a family of 10 SAP genes, have been investigated as the virulent factors during candidiasis.
Candida and candidiasis in HIV-infected patients: where commensalism, opportunistic behavior and frank pathogenicity lose their borders.
Review
Cauda et al., Roma, Italy. In Aids, 2012
In addition, HIV infection generates an 'environment' selecting for overexpression of the virulence potential by the fungus, particularly concerning the secreted aspartyl proteinases (Saps).
Substrate specificity of lymphoid-specific tyrosine phosphatase (Lyp) and identification of Src kinase-associated protein of 55 kDa homolog (SKAP-HOM) as a Lyp substrate.
GeneRIF
Zhang et al., Indianapolis, United States. In J Biol Chem, 2011
analysis of substrate specificity of lymphoid-specific tyrosine phosphatase (Lyp) and identification of Src kinase-associated protein of 55 kDa homolog (SKAP-HOM) as a Lyp substrate
SKAP2, a novel target of HSF4b, associates with NCK2/F-actin at membrane ruffles and regulates actin reorganization in lens cell.
GeneRIF
Hu et al., Shanghai, China. In J Cell Mol Med, 2011
These results revealed an essential role for HSF4-mediated SKAP2 expression in the regulation of actin reorganization during lens differentiation.
Aspartic protease inhibitors as potential anti-Candida albicans drugs: impacts on fungal biology, virulence and pathogenesis.
Review
Santos et al., Rio de Janeiro, Brazil. In Curr Med Chem, 2010
Some virulence factors, like the secreted aspartic proteases (Saps), play a role in several infection stages and the inhibition of one of the many stages may contribute to the containment of the pathogen and thus should help in the treatment of disease.
Expression of SKAP-HOM in DCs is required for an optimal immune response in vivo.
GeneRIF
Togni et al., Magdeburg, Germany. In J Leukoc Biol, 2009
SKAP-HOM expression in DCs is required for the induction of an optimal immune response; antigen-dependent conjugate formed between wild-type T cells and SKAP-HOM(-/-) DCs is delayed
Genome-wide DNA copy number analysis in pancreatic cancer using high-density single nucleotide polymorphism arrays.
GeneRIF
Lemoine et al., London, United Kingdom. In Oncogene, 2008
Overexpression of SKAP2 is associated with the development of pancreatic ductal adenocarcinoma
RIAM links the ADAP/SKAP-55 signaling module to Rap1, facilitating T-cell-receptor-mediated integrin activation.
GeneRIF
Koretzky et al., Philadelphia, United States. In Mol Cell Biol, 2007
Results describe a link between ADAP/SKAP-55 and the Rap1/RIAM complex and provide a potential new mechanism for T cell receptor-mediated integrin activation.
Hydrolytic enzymes as virulence factors of Candida albicans.
Review
Hube et al., München, Germany. In Mycoses, 2005
The most discussed hydrolytic enzymes produced by C. albicans are secreted aspartic proteinases (Saps).
Principles of lysosomal membrane digestion: stimulation of sphingolipid degradation by sphingolipid activator proteins and anionic lysosomal lipids.
Review
Sandhoff et al., Bonn, Germany. In Annu Rev Cell Dev Biol, 2004
The lysosomal degradation of sphingolipids with short hydrophilic head groups requires the presence of sphingolipid activator proteins (SAPs).
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