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Mitogen-activated protein kinase 9

SAPK, JNK2, Mitogen-Activated Protein Kinase 9, Jun kinase, c-Jun kinase
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Sep 2008] (from NCBI)
Top mentioned proteins: JNK, AP-1, p38, MAPK, V1a
Papers using SAPK antibodies
Sunday Driver links axonal transport to damage signaling
Supplier
Goldstein Lawrence S.B. et al., In The Journal of Cell Biology, 1998
... and anti-p50 (BD Biosciences), anti-JNK1 and anti-JNK2 (BD Biosciences), anti-JNK3 (Upstate Biotechnology), anti–P-JNK ...
Integrin-dependent adhesive activity is spatially controlled by inductive signals at gastrulation.
Supplier
Zhang Lin, In PLoS ONE, 1995
... ), JNK2 SMARTpool siRNA (Thermo Scientific) and alternate JNK2 siRNA: ...
TNF-a induces tyrosine phosphorylation of mitogen-activated protein kinase in adherent human neutrophils
Supplier
Binion David G et al., In Cell communication and signaling : CCS, 1994
... -terminal MAPK (SAPK)) were from New England Biolabs (Beverly, MA) ...
Gene induction by gamma-irradiation leads to DNA fragmentation in lymphocytes
Supplier
Kitanaka C et al., In Cell Death & Disease, 1986
... Anti-ERK2 antibody, polyclonal anti-Bak antibody (G-23), polyclonal anti-Bax antibody (N-20), anti-Bcl-2 antibody (N-19), anti-total JNK2 antibody, and horseradish peroxidase-conjugated anti-goat IgG secondary antibodies were from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Papers on SAPK
BMP-6 modulates somatostatin effects on luteinizing hormone production by gonadrotrope cells.
New
Makino et al., Okayama, Japan. In Peptides, Feb 2016
In addition, GnRH-induced phosphorylation of MAPKs including ERK, but not P38 or SAPK, was suppressed by pasireotide in the presence of BMP-6.
Low-dose occupational exposure to benzene and signal transduction pathways involved in the regulation of cellular response to oxidative stress.
New
Costa et al., Messina, Italy. In Life Sci, Feb 2016
This study aims to evaluate the effects of low-dose, long-term exposure on NF-κB, STAT3, p38-MAPK and stress-activated protein kinase/Jun amino-terminal kinase (SAPK/JNK) signal transduction pathways in peripheral blood mononuclear cells in gasoline station attendants.
Mimosine suppresses the PGF2α-induced synthesis of osteoprotegerin but not interleukin-6 in osteoblasts.
New
Tokuda et al., Nagoya, Japan. In Int J Mol Med, Feb 2016
We previously reported that prostaglandin F2α (PGF2α) induced osteoprotegerin synthesis through p38 mitogen-activated protein (MAP) kinase, p44/p42 MAP kinase and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) in osteoblast-like MC3T3-E1 cells.
The Epstein-Barr virus encoded LMP1 oncoprotein modulates cell adhesion via regulation of activin A/TGFβ and β1 integrin signalling.
New
Young et al., Kuala Lumpur, Malaysia. In Sci Rep, Dec 2015
Latent membrane protein 1 (LMP1), the major oncoprotein encoded by EBV, behaves as a constitutively active tumour necrosis factor (TNF) receptor activating a variety of signalling pathways, including the three classic MAPKs (ERK-MAPK, p38 MAPK and JNK/SAPK).
Molecular Pathways: Targeting the CXCR4-CXCL12 Axis--Untapped Potential in the Tumor Microenvironment.
Review
New
Scala, Napoli, Italy. In Clin Cancer Res, Nov 2015
The homeostatic microenvironment chemokine CXCL12 binds the CXCR4 and CXCR7 receptors, activating divergent signals on multiple pathways, such as ERK1/2, p38, SAPK/JNK, AKT, mTOR, and the Bruton tyrosine kinase (BTK).
Stress kinases in the modulation of metabolism and energy balance.
Review
New
Sabio et al., Madrid, Spain. In J Mol Endocrinol, Oct 2015
Stress-activated protein kinases (SAPK), including cJun N-terminal kinases (JNKs) and p38, are required for cellular responses to metabolic stress and therefore might contribute to the pathogenesis of obesity.
Birth defects in pregestational diabetes: Defect range, glycemic threshold and pathogenesis.
Review
New
Yang et al., Baltimore, United States. In World J Diabetes, May 2015
Deletion of the ASK1 gene, the JNK1 gene, or the JNK2 gene, or inhibition of ER stress by 4-Phenylbutyric acid abrogates diabetes-induced apoptosis and reduces the formation of NTDs.
Buyanghuanwu Tang therapy for neonatal rats with hypoxic ischemic encephalopathy.
Tian et al., Xiamen, China. In Int J Clin Exp Med, 2014
The changes of hippocampal tissue observed by histopathologic examination, and the expressions of JNK1/JNK2 and TNF-α protein were observed western blotting.
Molecular biology of the stress response in the early embryo and its stem cells.
Review
Rappolee et al., Detroit, United States. In Adv Exp Med Biol, 2014
Important protein kinases that mediate the stress response of embryos and their stem cells are SAPK, p38MAPK, AMPK, PI3K, Akt, MEK1/2, MEKK4, PKA, IRE1 and PERK.
Rho GTPases: Novel Players in the Regulation of the DNA Damage Response?
Review
Henninger et al., Düsseldorf, Germany. In Biomolecules, 2014
Rac1 also adjusts cellular responses to genotoxic stress by regulating the activity of stress kinases, including c-Jun-N-terminal kinase/stress-activated protein kinase (JNK/SAPK) and p38 kinases as well as related transcription factors.
Coordinated control of replication and transcription by a SAPK protects genomic integrity.
Impact
Posas et al., Barcelona, Spain. In Nature, 2013
In response to osmostress, hundreds of stress-responsive genes are rapidly induced by the stress-activated protein kinase (SAPK) Hog1 (ref.
Delayed cell cycle progression in selenoprotein W-depleted cells is regulated by a mitogen-activated protein kinase kinase 4-p38/c-Jun NH2-terminal kinase-p53 pathway.
GeneRIF
Alkan et al., Davis, United States. In J Biol Chem, 2012
SEPW1 silencing increases MKK4, which activates p38gamma, p38delta, and JNK2 to phosphorylate p53 on Ser-33 and cause a transient G(1) arrest.
Increased JNK in males compared with females in a rodent model of abdominal aortic aneurysm.
GeneRIF
Upchurch et al., Ann Arbor, United States. In J Surg Res, 2012
Alterations in JNK between genders is partially responsible for the differential rates of experimental abdominal aortic aneurysm formation, likely through differential regulation of MMPs.
Elevated hepatic multidrug resistance-associated protein 3/ATP-binding cassette subfamily C 3 expression in human obstructive cholestasis is mediated through tumor necrosis factor alpha and c-Jun NH2-terminal kinase/stress-activated protein kinase-signaling pathway.
GeneRIF
Chen et al., Chongqing, China. In Hepatology, 2012
up-regulation of hepatic MRP3/ABCC3 expression in human obstructive cholestasis is likely triggered by TNFalpha, mediated by activation of JNK/SAPK and SP1.
JNK regulates the photic response of the mammalian circadian clock.
GeneRIF
Fukada et al., Tokyo, Japan. In Embo Rep, 2012
Mice deficient for neuron-specific isoform JNK3 have altered behavioural rhythms, with longer free-running period and compromised phase shifts to light.
Effect of ulinastatin on growth inhibition, apoptosis of breast carcinoma cells is related to a decrease in signal conduction of JNk-2 and NF-κB.
GeneRIF
Sun et al., Chongqing, China. In J Exp Clin Cancer Res, 2011
ulinastatin inhibits the proliferation of human breast cancer cells and the growth of xenografted tumors.This mechanism might be related to decreasing signal transduction of JNk-2 and NF-kappaB.
The stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression.
Impact
Penninger et al., Vienna, Austria. In Nat Genet, 2011
Mechanistically, MKK7 acts through the kinases JNK1 and JNK2, and this signaling pathway directly couples oncogenic and genotoxic stress to the stability of p53, which is required for cell cycle arrest and suppression of epithelial cancers.
Formation of stress granules inhibits apoptosis by suppressing stress-responsive MAPK pathways.
Impact
Takekawa et al., Tokyo, Japan. In Nat Cell Biol, 2008
Type 2 stress, which includes X-rays and genotoxic drugs, induce apoptosis through the stress-activated p38 and JNK MAPK (SAPK) pathways.
Rac1 activation controls nuclear localization of beta-catenin during canonical Wnt signaling.
Impact
Long et al., Saint Louis, United States. In Cell, 2008
The role of Rac1 depends on phosphorylation of beta-catenin at Ser191 and Ser605, which is mediated by JNK2 kinase.
The CARMA1-Bcl10 signaling complex selectively regulates JNK2 kinase in the T cell receptor-signaling pathway.
Impact
Lin et al., Houston, United States. In Immunity, 2007
Although many studies have indicated that JNK1 and JNK2 have functional differences and redundancy, the upstream signaling pathway that selectively activates JNK1 or JNK2 remains unknown.
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