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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

ATG16 Atg16p

SAP18, ATG16, Apg16
Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter. A pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2008] (from NCBI)
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Top mentioned proteins: Atg5, Atg12, Ubiquitin, LC3, mSin3A
Papers on SAP18
Microbial Disruption of Autophagy Alters Expression of the RISC Component AGO2, a Critical Regulator of the miRNA Silencing Pathway.
Jones et al., Toronto, Canada. In Inflamm Bowel Dis, Dec 2015
RESULTS: Increased AGO2 was detected in autophagy-deficient ATG5-/- and ATG16-/- mouse embryonic fibroblast cells (MEFs) in comparison with wild-type MEFs.
Expression of Autophagy-Related Proteins in the Spinal Cord of Pembroke Welsh Corgi Dogs With Canine Degenerative Myelopathy.
Nakayama et al., Tokyo, Japan. In Vet Pathol, Nov 2015
Western blotting revealed in DM dogs the decreased expression of Beclin1 and Atg16 L, which are molecules involved in formation of the isolation membrane.
Sin3A-associated protein, 18 kDa, a novel binding partner of TRIB1, regulates MTTP expression.
Iwamoto et al., Tochigi, Japan. In J Lipid Res, Jun 2015
Sin3A-associated protein, 18 kDa (SAP18) was identified as a novel binding partner of TRIB1.
The phenotypes of ATG9, ATG16 and ATG9/16 knock-out mutants imply autophagy-dependent and -independent functions.
Eichinger et al., Köln, Germany. In Open Biol, Apr 2015
Here, we describe the phenotypes of Dictyostelium discoideum ATG16(-) and ATG9(-)/16(-) cells and compare them to the previously reported ATG9(-) mutant.
Myristoylation confers noncanonical AMPK functions in autophagy selectivity and mitochondrial surveillance.
Mills et al., Houston, United States. In Nat Commun, 2014
Mitochondrial damage induces a physical association of AMPK with ATG16-ATG5-12 and an AMPK-dependent recruitment of the VPS34 and ATG16 complexes with the mitochondria.
TipC and the chorea-acanthocytosis protein VPS13A regulate autophagy in Dictyostelium and human HeLa cells.
Escalante et al., Madrid, Spain. In Autophagy, 2014
tipD codes for a homolog of Atg16, which confirms the role of this protein in Dictyostelium autophagy and validates our approach.
AMDE-1 is a dual function chemical for autophagy activation and inhibition.
Yin et al., Guangzhou, China. In Plos One, 2014
This molecule, termed as Autophagy Modulator with Dual Effect-1 (AMDE-1), triggered autophagy in an Atg5-dependent manner, recruiting Atg16 to the pre-autophagosomal site and causing LC3 lipidation.
Connexins modulate autophagosome biogenesis.
Cuervo et al., New York City, United States. In Nat Cell Biol, 2014
We have found that plasma-membrane-localized Cx proteins constitutively downregulate autophagy through a direct interaction with several autophagy-related proteins involved in the initial steps of autophagosome formation, such as Atg16 and components of the PI(3)K autophagy initiation complex (Vps34, Beclin-1 and Vps15).
Molecular mechanism of autophagic membrane-scaffold assembly and disassembly.
Wollert et al., Martinsried, Germany. In Cell, 2014
A key step in the pathway is the covalent conjugation of the ubiquitin-related protein Atg8 to phosphatidylethanolamine (Atg8-PE) in autophagic membranes by a complex consisting of Atg16 and the Atg12-Atg5 conjugate.
The role of the selective adaptor p62 and ubiquitin-like proteins in autophagy.
Lőw et al., Budapest, Hungary. In Biomed Res Int, 2013
Two ubiquitin-like protein conjugation pathways were discovered that are required for autophagosome biogenesis: the Atg12-Atg5-Atg16 and Atg8 systems.
Two ubiquitin-like conjugation systems that mediate membrane formation during autophagy.
Nakatogawa, Yokohama, Japan. In Essays Biochem, 2012
Sequential reactions by the E1 enzyme Atg7 and the E2 enzyme Atg10 conjugate Atg12 to the lysine residue in Atg5, and the resulting Atg12-Atg5 conjugate forms a complex with Atg16.
Evidence from genetics for a role of autophagy and innate immunity in IBD pathogenesis.
Parkes, Cambridge, United Kingdom. In Dig Dis, 2011
Thus ATG16 hypomorphic mice show major morphological change in Paneth cells--also observed in humans homozygous for the ATG16L1T300A.
Drosophila melanogaster SAP18 protein is required for environmental stress responses.
Espinàs et al., Barcelona, Spain. In Febs Lett, 2011
dSAP18 is a key player in transcriptional responses to stress.
Human SAP18 mediates assembly of a splicing regulatory multiprotein complex via its ubiquitin-like fold.
Schwerk et al., Düsseldorf, Germany. In Rna, 2010
A novel function of SAP18 in splicing regulation.
Dimeric coiled-coil structure of Saccharomyces cerevisiae Atg16 and its functional significance in autophagy.
Inagaki et al., Sapporo, Japan. In J Biol Chem, 2010
Evolutionary conserved surface residues clustered at the C-terminal half of Atg16 CCD were shown to be crucial for autophagy.
Recruitment of a SAP18-HDAC1 complex into HIV-1 virions and its requirement for viral replication.
Kalpana et al., New York City, United States. In Plos Pathog, 2009
study indicates HIV-1 integrase & INI1/hSNF5 bind SAP18 & recruit components of Sin3a-HDAC1 complex into HIV-1 virions; HIV-1 virion-associated HDAC1 is required for efficient early post-entry events, indicating novel role for HDAC1 in HIV-1 replication
SAP18 promotes Krüppel-dependent transcriptional repression by enhancer-specific histone deacetylation.
Jäckle et al., Göttingen, Germany. In J Biol Chem, 2009
Kruppel tethers the SAP18 bound histone deacetylase complex 1 at distinct enhancer elements, which causes repression via histone H3 deacetylation
A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells.
Virgin et al., Saint Louis, United States. In Nature, 2008
One Crohn's disease risk allele is in ATG16L1, a gene homologous to the essential yeast autophagy gene ATG16 (ref.
The hedgehog signaling network.
Cohen, Halifax, Canada. In Am J Med Genet A, 2003
Many more factors that are essential for the hedgehog signaling network are also discussed: Megalin, Rab23, Hip, GAS1, PKA, GSK3, CK1, Slimb, SAP18, and CBP.
Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex.
Reinberg et al., United States. In Cell, 1997
In addition, two novel mSin3-associated polypeptides, SAP18 and SAP30, were identified.
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