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ELK4, ETS-domain protein

SAP1, ELK4
This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is phosphorylated by the kinases, MAPK1 and MAPK8. Several transcript variants have been described for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: SAP, NET, ACID, CAN, serum response factor
Papers on SAP1
Phospholipase and Aspartyl Proteinase Activities of Candida Species Causing Vulvovaginal Candidiasis in Patients with Type 2 Diabetes Mellitus.
New
AboElnaga et al., Al Fayyūm, Egypt. In J Microbiol Biotechnol, Nov 2015
Detection of aspartyl proteinase genes (SAP1 to SAP8) and phospholipase genes (PLB1, PLB2) were performed by multiplex polymerase chain reaction.
Protein tyrosine phosphatase SAP-1 protects against colitis through regulation of CEACAM20 in the intestinal epithelium.
New
Matozaki et al., Kōbe, Japan. In Proc Natl Acad Sci U S A, Sep 2015
Stomach-cancer-associated protein tyrosine phosphatase 1 (SAP-1, also known as PTPRH) is a receptor-type protein tyrosine phosphatase that is localized specifically at microvilli of the brush border in gastrointestinal epithelial cells.
Cyclin-dependent kinase 2 (CDK2) is a key mediator for EGF-induced cell transformation mediated through the ELK4/c-Fos signaling pathway.
New
Chen et al., Austin, United States. In Oncogene, Jul 2015
Interestingly, CDK2 directly phosphorylates ELK4 at Thr194 and Ser387 and regulates the ELK4 transcriptional activity, which serves as a mechanism to regulate c-fos expression.
Inactivation of the antifungal and immunomodulatory properties of human cathelicidin LL-37 by aspartic proteases produced by the pathogenic yeast Candida albicans.
New
Kozik et al., Kraków, Poland. In Infect Immun, Jun 2015
LL-37 is cleaved into multiple products by SAP1 to -4, SAP8, and SAP9, and this proteolytic processing is correlated with the gradual decrease in the antifungal activity of LL-37.
Multiple barcode assessment within the Saprolegnia-Achlya clade (Saprolegniales, Oomycota, Straminipila) brings order in a neglected group of pathogens.
Belbahri et al., La Plata, Argentina. In Ima Fungus, 2014
A consensus tree of the three genes provided support for nine clades encompassing eleven documented genera and a new clade (SAP1) that has not been described morphologically.
Secretory Aspartyl Proteinases Cause Vaginitis and Can Mediate Vaginitis Caused by Candida albicans in Mice.
Cassone et al., Perugia, Italy. In Mbio, 2014
The same antibodies and Pepstatin A also inhibited neutrophil influx and cytokine production stimulated by C. albicans intravaginal injection, and a mutant strain lacking SAP1, SAP2, and SAP3 was unable to cause vaginal inflammation.
SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation.
Impact
Chua et al., Stanford, United States. In Nature, 2012
The spectrum of SIRT7 target genes is defined in part by its interaction with the cancer-associated E26 transformed specific (ETS) transcription factor ELK4, and comprises numerous genes with links to tumour suppression.
Navβ subunits modulate the inhibition of Nav1.8 by the analgesic gating modifier μO-conotoxin MrVIB.
GeneRIF
Yoshikami et al., Salt Lake City, United States. In J Pharmacol Exp Ther, 2011
Coexpression of beta-subunits of NaV1.8 strongly influences the affinity of the muO-conotoxin MrVIB conopeptide for the channel.
Expression, localization, and biological function of the R3 subtype of receptor-type protein tyrosine phosphatases in mammals.
Review
Ohnishi et al., Maebashi, Japan. In Cell Signal, 2010
The R3 subtype of receptor-type protein tyrosine phosphatases (RPTPs) includes VE-PTP, DEP-1, PTPRO, and SAP-1.
Ternary complex factors SAP-1 and Elk-1, but not net, are functionally equivalent in thymocyte development.
GeneRIF
Treisman et al., London, United Kingdom. In J Immunol, 2010
Data show that Elk-1 and Net do not contribute significantly to thymocyte development in the presence of SAP-1.
Transcriptome sequencing to detect gene fusions in cancer.
Impact
GeneRIF
Chinnaiyan et al., Ann Arbor, United States. In Nature, 2009
SLC45A3?ELK4 may represent the first description of a recurrent RNA chimaeric transcript specific to prostate cancer that does not have a detectable DNA aberration
SAP-1 is a microvillus-specific protein tyrosine phosphatase that modulates intestinal tumorigenesis.
GeneRIF
Matozaki et al., Maebashi, Japan. In Genes Cells, 2009
These results thus suggest that SAP-1 is a microvillus-specific receptor-type protein tyrosine phosphatase that regulates intestinal tumorigenesis.
Identification of ETS-like transcription factor 4 as a novel androgen receptor target in prostate cancer cells.
GeneRIF
Palvimo et al., Kuopio, Finland. In Oncogene, 2008
ELK4 is a direct androgen receptor target in prostate cancer cells. Androgens may thus contribute to the growth of prostate cancer via influencing ELK4 levels
Ternary complex factor SAP-1 is required for Erk-mediated thymocyte positive selection.
Impact
GeneRIF
Treisman et al., London, United Kingdom. In Nat Immunol, 2004
SAP-1 is required for Erk-mediated transcriptional events in thymocyte development.
Ets ternary complex transcription factors.
Review
Wasylyk et al., Illkirch-Graffenstaden, France. In Gene, 2004
The three ternary complex factors (TCFs) Elk-1, Net and Sap-1 form a subfamily of the E twenty-six (Ets) domain transcription factors.
Transcription factor complexes.
Review
Kamada et al., New York City, United States. In Curr Opin Struct Biol, 2002
Recently determined structures include negative cofactor 2 recognizing a preformed TATA-box-binding protein-DNA binary complex, a dimer of BmrR bound to both DNA and tetra-phenylphosphonium, DNA-bound complexes of SarA and FadR, leukemia-associated AML1-CBFbeta-DNA ternary complexes and a SAP1-SRF-DNA ternary complex.
[What functions do six different genes for secretory proteinases have in Candida albicans?].
Review
Gow et al., Hamburg, Germany. In Mycoses, 1997
Sap isoenzymes are encoded by at least nine different genes (SAP1-9), which are differentially regulated in vitro.
Ets oncogene family.
Review
Dhulipal, Philadelphia, United States. In Indian J Exp Biol, 1997
Subsequently, a series of cellular Ets genes were isolated (Ets-1, Ets-2, Erg, Elk-1, Sap-1, PEA-3, PU.1, Fli-1, Pok/Yan, Etv-1 etc.).
Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element.
Impact
Treisman et al., London, United Kingdom. In Cell, 1992
We used a yeast genetic screen to isolate cDNAs that encode a protein, SRF accessory protein-1 (SAP-1), that is recruited to the c-fos serum response element (SRE) as part of a ternary complex that includes serum response factor (SRF).
Coding of two sphingolipid activator proteins (SAP-1 and SAP-2) by same genetic locus.
Impact
Fluharty et al., San Diego, United States. In Science, 1988
The nucleotide sequence of the largest cDNA was colinear with the derived amino acid sequence of SAP-2 and with the nucleotide sequence of the cDNA coding for the 70-kilodalton precursor of SAP-1 (SAP precursor cDNA).
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