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Torsin family 2, member A

Salusin-alpha, Salusin-beta, TOR2A, Torsin-related protein of
This gene encodes a member of the AAA family of adenosine triphosphatases with similarity to Clp proteases and heat shock proteins. Alternative splicing at this locus results in the translation of multiple isoforms of the encoded protein, some of which contain salusin peptides in the C-terminal region. These peptides may play roles in hypotension, myocardial growth and the induction of mitogenesis, and may also be involved in the pathogenesis of atherosclerosis. [provided by RefSeq, Oct 2011] (from NCBI)
Top mentioned proteins: ACID, CAN, TUBE, Insulin, HAD
Papers on Salusin-alpha
Microinjection of salusin-beta into the nucleus tractus solitarii inhibits cardiovascular function by suppressing presympathetic neurons in rostral ventrolateral medulla in rats.
Yuan et al., Lanzhou, China. In Physiol Res, 2014
Salusin-beta is newly identified bioactive peptide of 20 amino acids, which is widely distributed in hematopoietic system, endocrine system, and the central nervous system (CNS).
Salusin-alpha and -beta expression in heart and aorta with and without metabolic syndrome.
Aydin et al., Elazığ, Turkey. In Biotech Histochem, 2014
We examined the distribution of salusin alpha (sal-α) and salusin beta (sal-β) immunoreactivity in heart and aortic tissues and measured circulating salusin concentrations, glucose, insulin, triglycerides, free fatty acids, uric acid, and total cholesterol in Sprague-Dawley rats with and without MetS.
Concentrations of preptin, salusins and hepcidins in plasma and milk of lactating women with or without gestational diabetes mellitus.
Kumru et al., Elazığ, Turkey. In Peptides, 2013
This study was undertaken to ascertain whether human milk contains preptin, salusin-alpha (salusin-α) and -beta (salusin-β) and pro-hepcidin and hepcidin-25, and whether there are relationships between plasma and milk preptin, salusin-α and -β and pro-hepcidin and hepcidin-25 concentrations in lactating mothers with and without gestational diabetes mellitus (GDM).
[Physicochemical characteristics of salusin-beta and establishment of the radioimmunoassay].
Shichiri et al., Tokyo, Japan. In Rinsho Byori, 2011
Salusin-beta is a 20 amino acid bioactive peptide originally identified using bioinformatic analyses of human full-length enriched cDNA library.
Chronic infusion of salusin-alpha and -beta exerts opposite effects on atherosclerotic lesion development in apolipoprotein E-deficient mice.
GeneRIF
Hirano et al., Tokyo, Japan. In Atherosclerosis, 2010
Salusin-beta accelerates the development of atherosclerotic lesions in APOE knockout mice whilst salusin-alpha exerts anti-atherosclerotic effects.
Serum levels and urinary excretion of salusin-alpha in renal insufficiency.
Shichiri et al., Tokyo, Japan. In Regul Pept, 2010
Salusin-alpha was recently shown to exert anti-atherosclerotic effects and its potential role as a clinical marker for atherosclerosis has been proposed.
Release of salusin-beta from human monocytes/macrophages.
Shichiri et al., Tokyo, Japan. In Regul Pept, 2010
Salusin-alpha and salusin-beta are related bioactive peptides biosynthesized from the same precursor, prosalusin.
Inhibition of L-type calcium currents by salusin-beta in rat cardiac ventricular myocytes.
Ren et al., Shanghai, China. In Peptides, 2010
Salusin-beta is a new regulatory peptide relevant to the cardiovascular system and exerts negative inotropic effect on ventricular muscle.
Mutant torsinA interacts with tyrosine hydroxylase in cultured cells.
GeneRIF
Lockhart et al., Jacksonville, United States. In Neuroscience, 2010
Our results suggest that the interaction of tyrosine hydroxylase and mutant torsinA may contribute to the phenotype and reported dopaminergic dysfunction in torsinA-mediated dystonia.
Presence of immunoreactive salusin-beta in human plasma and urine.
Shichiri et al., Tokyo, Japan. In Regul Pept, 2009
Salusin-alpha and salusin-beta are multifunctional bioactive peptides originally identified using bioinformatics analyses.
Biosynthesis and secretion of salusin-alpha from human cells.
GeneRIF
Shichiri et al., Tokyo, Japan. In Peptides, 2008
salusin-alpha is biosynthesized and released from human-derived cells.
Serum salusin-alpha levels are decreased and correlated negatively with carotid atherosclerosis in essential hypertensive patients.
GeneRIF
Miyazaki et al., Tokyo, Japan. In Hypertens Res, 2008
Decrease in serum salusin-alpha, an anti-atherogenic peptide, may be associated with carotid atherosclerosis in hypertensive patients.
Impact of salusin-alpha and -beta on human macrophage foam cell formation and coronary atherosclerosis.
Miyazaki et al., Tokyo, Japan. In Circulation, 2008
Immunoreactive salusin-alpha and -beta were detected in human coronary atherosclerotic plaques, with dominance of salusin-beta in vascular smooth muscle cells and fibroblasts.
Systemic distribution of salusin expression in the rat.
Hirata et al., Tokyo, Japan. In Hypertens Res, 2007
Salusin-alpha and salusin-beta are multifunctional bioactive peptides with hypotensive and bradycardic effects.
Presence of immunoreactive salusin-alpha in human serum and urine.
Shichiri et al., Tokyo, Japan. In Peptides, 2006
We developed a radioimmunoassay suitable for the detection of immunoreactive human salusin-alpha and characterized the molecular forms and concentrations of salusin-alpha in human serum and urine.
Salusins protect neonatal rat cardiomyocytes from serum deprivation-induced cell death through upregulation of GRP78.
Wen-Jun et al., Shanghai, China. In J Cardiovasc Pharmacol, 2006
Salusin-alpha and salusin-beta are newly identified bioactive peptides with hemodynamic and mitogenic activities.
Salusin beta is a surrogate ligand of the mas-like G protein-coupled receptor MrgA1.
GeneRIF
Civelli et al., Irvine, United States. In Eur J Pharmacol, 2006
Human salusin beta is a surrogate ligand of mouse MrgA1.
Salusins: newly identified bioactive peptides with hemodynamic and mitogenic activities.
Impact
GeneRIF
Hirata et al., Tokyo, Japan. In Nat Med, 2003
the identification and characterization of two related peptides of 28 and 20 amino acids, which we designated salusin-alpha and salusin-beta. Salusins are translated from an alternatively spliced mRNA of TOR2A
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