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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Sal-like 4

SALL4
The protein encoded by this gene may be a zinc finger transcription factor. Defects in this gene are a cause of Duane-radial ray syndrome (DRRS). [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, Adenylate Cyclase, HAD, Sox2, Nanog
Papers on SALL4
Expression and clinical significance of SALL4 and β-catenin in colorectal cancer.
New
Su et al., Shenyang, China. In J Mol Histol, Feb 2016
UNASSIGNED: Previous studies on the expression of Sal-like 4 (SALL4), a zinc finger transcription factor, had conflicting results in colorectal cancer (CRC).
SALL4 is a marker of poor prognosis in serous ovarian carcinoma promoting invasion and metastasis.
New
Ding et al., Changsha, China. In Oncol Rep, Feb 2016
UNASSIGNED: Spalt-like transcription factor 4 (SALL4) is a transcription factor which is able to regulate development and embryonic stem cell pluripotency, and it is also involved in some tumor progression.
Sex difference of autosomal alleles in populations of European and African descent.
New
Luo et al., New Haven, United States. In Journal 2093-4947, Jan 2016
We found 13 markers that were genome-wide significant (p≤5×10(-8)) between females and males in the meta-analysis of all cohorts of European descent, including rs7740449 at SYNE1, rs7531151 at PLD5, rs697455 at PPP1R12B, rs6745746 at LOC100128413, rs17000079 at PARM1, rs11948070 at PDE4D, rs7801825 at INSIG1, rs9551642 at MTUS2, rs2932174 at TPTE2, rs1961597 at SALL3, rs4117529 at METTL4, rs6021473 at SALL4 and rs6092466 at RAE1, and one marker, i.e., rs10145208 at PCNX, that was genome-wide significant in the meta-analysis of all cohorts of African descent.
Expression and clinical significance of SALL4 and LGR5 in patients with lung cancer.
New
Mo et al., Guilin, China. In Oncol Lett, Dec 2015
The purpose of the present study is to investigate the expression and clinical significance of the stem cell-associated markers Sal-like protein 4 (SALL4) and leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5) in lung cancer, and to provide novel diagnostic markers and targets for the treatment of lung cancer.
Cancer stem cells in oesophageal squamous cell carcinoma: Identification, prognostic and treatment perspectives.
Review
New
Lam et al., Gold Coast, Australia. In Crit Rev Oncol Hematol, Oct 2015
It has also been demonstrated that stem cell markers like ALDH1, HIWI, Oct3/4, ABCG2, SOX2, SALL4, BMI-1, NANOG, CD133 and podoplanin are associated with patient's prognosis, pathological stages, cancer recurrence and therapy resistance.
Carcinosarcoma with Choriocarcinomatous and Osteosarcomatous Differentiation in a Patient with Juvenile Polyposis Syndrome.
New
Polo et al., Bogotá, Colombia. In Rare Tumors, Oct 2015
Immunohistochemistry was AE1/AE3, CK7, HCG and SALL4 positive.
Towards elucidating the stability, dynamics and architecture of the nucleosome remodeling and deacetylase complex by using quantitative interaction proteomics.
Review
New
Vermeulen et al., Nijmegen, Netherlands. In Febs J, May 2015
Some of these interactions are salt-sensitive (ZNF512B and SALL4), whereas others (ZMYND8) are not.
SALL4: an emerging cancer biomarker and target.
Review
New
Xu et al., Zhenjiang, China. In Cancer Lett, Mar 2015
SALL4 is a transcription factor that plays essential roles in maintaining self-renewal and pluripotency of embryonic stem cells (ESCs).
High cytoplasmic expression of SALL4 predicts a malignant phenotype and poor prognosis of breast invasive ductal carcinoma.
Zhang et al., In Neoplasma, 2014
Sal-like 4(SALL4) is significant for maintaining self-renewal and pluripotency in embryonic stem cells, cancer cells and perhaps even cancer stem cells.
Inhibition of SALL4 suppresses carcinogenesis of colorectal cancer via regulating Gli1 expression.
Tao et al., Wuhan, China. In Int J Clin Exp Pathol, 2014
BACKGROUND: SALL4 is a novel oncogene mediating tumorigenesis in multiple carcinomas.
Association of PAX2 and Other Gene Mutations with the Clinical Manifestations of Renal Coloboma Syndrome.
Wada et al., Kanazawa, Japan. In Plos One, 2014
Moreover, four other sequence variants (CHD7, SALL4, KIF26B, and SIX4) were also confirmed, including a potentially pathogenic novel KIF26B mutation.
Molecular biology of liver cancer stem cells.
Review
Kaneko et al., Kanazawa, Japan. In Liver Cancer, 2014
Recent work has also identified Sal-like protein 4 (SALL4) and some epigenetic regulations as important molecules, while several therapeutic drugs that directly control HPCs have been tested both in vivo and in vitro.
SALL4: engine of cell stemness.
Review
Xiong, Bethesda, United States. In Curr Gene Ther, 2013
In vertebrates, the expression of sal-like 4 (SALL4) is specifically enriched in both embryonic and adult stem/stem-like cells.
Oncofetal gene SALL4 in aggressive hepatocellular carcinoma.
Impact
Tenen et al., Singapore, Singapore. In N Engl J Med, 2013
The oncofetal gene SALL4, a marker of a subtype of hepatocellular carcinoma with progenitor-like features, is associated with a poor prognosis and is a potential target for treatment.
The expression and oncogenic effects of the embryonic stem cell marker SALL4 in ALK-positive anaplastic large cell lymphoma.
GeneRIF
Lai et al., Edmonton, Canada. In Cell Signal, 2012
SALL4 knockdown results in downregulation of anti-apoptotic proteins, activation of the caspases.
Role of SALL4 in hematopoiesis.
Review
GeneRIF
Ma et al., Stony Brook, United States. In Curr Opin Hematol, 2012
The emerging knowledge about how SALL4 regulates HSC behavior may be used in the near future to develop advanced cell therapies, for example, through large-scale stem cell expansion ex vivo.
Diagnostic utility of CD117, CD133, SALL4, OCT4, TCL1 and glypican-3 in malignant germ cell tumors of the ovary.
GeneRIF
Kikkawa et al., Nagoya, Japan. In J Obstet Gynaecol Res, 2012
SALL4 is a more sensitive and specific marker for yolk sac tumors than glypican-3
Functional antagonism between Sall4 and Plzf defines germline progenitors.
Impact
GeneRIF
Pandolfi et al., Boston, United States. In Cell Stem Cell, 2012
Plzf antagonizes Sall4 function by displacing Sall4 from cognate chromatin to induce Sall1 expression
Stem cell gene SALL4 suppresses transcription through recruitment of DNA methyltransferases.
GeneRIF
Ma et al., Las Vegas, United States. In J Biol Chem, 2012
stem cell self-renewal mediated by SALL4 via epigenetic machinery.
Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heart.
Impact
GeneRIF
Bruneau et al., Toronto, Canada. In Nat Genet, 2006
A positive and negative feed-forward circuit between Tbx5 and Sall4 ensures precise patterning of embryonic limb and heart and provides a unifying mechanism for heart/hand syndromes.
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