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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

NOP2/Sun domain family, member 2

Saki, Trm4, NSUN2, Misu, Ncl1p
This gene encodes a methyltransferase that catalyzes the methylation of cytosine to 5-methylcytosine (m5C) at position 34 of intron-containing tRNA(Leu)(CAA) precursors. This modification is necessary to stabilize the anticodon-codon pairing and correctly translate the mRNA. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Mar 2011] (from NCBI)
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Top mentioned proteins: CAN, V1a, c-Myc, caspase-3, iMpact
Papers on Saki
NSun2 delays replicative senescence by repressing p27 (KIP1) translation and elevating CDK1 translation.
Wang et al., Beijing, China. In Aging (albany Ny), Jan 2016
Here, we show that the tRNA methyltransferase NSun2 represses the expression of p27 in replicative senescence.
NSun2 Promotes Cell Growth via Elevating Cyclin-Dependent Kinase 1 Translation.
Wang et al., Beijing, China. In Mol Cell Biol, Jan 2016
The tRNA methytransferase NSun2 promotes cell proliferation, but the molecular mechanism has not been elucidated.
A Novel Single-Nucleotide Deletion (c.1020delA) in NSUN2 Causes Intellectual Disability in an Emirati Child.
Al-Gazali et al., Al `Ayn, United Arab Emirates. In J Mol Neurosci, Nov 2015
NOP2/Sun transfer RNA (tRNA) methyltransferase family member 2 encoded by NSUN2 gene is a highly conserved protein and has been shown to cause autosomal recessive ID type 5 (MRT5).
Proteinase-activated Receptor 2 Promotes Cancer Cell Migration through RNA Methylation-mediated Repression of miR-125b.
Wang et al., Beijing, China. In J Biol Chem, Nov 2015
Remarkably, knock down of NOP2/Sun domain family, member 2 (NSun2), a RNA methyltransferase, blocked the reduction in miR-125b induced by PAR2.
The epitranscriptome in modulating spatiotemporal RNA translation in neuronal post-synaptic function.
Bashir et al., Bristol, United Kingdom. In Front Cell Neurosci, 2014
Here, we propose that RNA modifications may be a critical regulator over the spatiotemporal control of protein-synthesis in neurons, which is supported by our finding that the RNA methylase NSun2 colocalizes with the translational-repressor FMRP at neuronal dendrites.
Frequencies of Six (Five Novel) STR Markers Linked to TUSC3 (MRT7) or NSUN2 (MRT5) Genes Used for Homozygosity Mapping of Recessive Intellectual Disability.
Zeinali et al., In Clin Lab, 2014
In this research, we aimed to find novel STRs for two common NS-ARID genes (TUSC3 and NSUN2) and, in addition, to identify allele frequencies of those STR markers.
Trm4 and Nsun2 RNA:m5C methyltransferases form metabolite-dependent, covalent adducts with previously methylated RNA.
Redman et al., Fort Wayne, United States. In Biochemistry, 2014
Trm4p from Saccharomyces cerevisiae and its mammalian orthologue Nsun2 fabricate 5-methylcytosine (m(5)C) in RNA molecules utilizing a dual-cysteine catalytic mechanism.
Methylation by NSun2 represses the levels and function of microRNA 125b.
Wang et al., Beijing, China. In Mol Cell Biol, 2014
Here, we show that the tRNA methyltransferase NSun2 methylates primary (pri-miR-125b), precursor (pre-miR-125b), and mature microRNA 125b (miR-125b) in vitro and in vivo.
Identification of genes important for cutaneous function revealed by a large scale reverse genetic screen in the mouse.
Smyth et al., Melbourne, Australia. In Plos Genet, 2014
Many of these were not previously associated with skin disease in the organ (Mysm1, Vangl1, Trpc4ap, Nom1, Sparc, Farp2, and Prkab1), while others were ascribed new cutaneous functions on the basis of the screening approach (Krt76, Lrig1, Myo5a, Nsun2, and Nf1).
Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders.
Frye et al., Paris, France. In Embo J, 2014
Mutations in the cytosine-5 RNA methyltransferase NSun2 cause microcephaly and other neurological abnormalities in mice and human.
tRNA modifying enzymes, NSUN2 and METTL1, determine sensitivity to 5-fluorouracil in HeLa cells.
Tatsuka et al., Hiroshima, Japan. In Plos Genet, 2014
The tRNA modifying enzymes, NSUN2 and METTL1, are mammalian orthologs of yeast Trm4 and Trm8, which are required for protecting tRNA against RTD.
Whole exome sequencing unravels disease-causing genes in consanguineous families in Qatar.
Ben-Omran et al., Montréal, Canada. In Clin Genet, 2014
Using WES approach, we identified the definitive disease-causing mutations in four families: (i) a novel nonsense homozygous (c.1034C>G) in PHKG2 causing glycogen storage disease type 9C (GSD9C) in a male with initial diagnosis of GSD3; (ii) a novel homozygous 1-bp deletion (c.915del) in NSUN2 in a male proband with Noonan-like syndrome; (iii) a homozygous SNV (c.1598C>G) in exon 11 of IDUA causing Hurler syndrome in a female proband with unknown clinical diagnosis; (iv) a de novo known splicing mutation (c.1645+1G>A) in PHEX in a female proband with initial diagnosis of autosomal recessive hypophosphatemic rickets.
NSun2-mediated cytosine-5 methylation of vault noncoding RNA determines its processing into regulatory small RNAs.
Frye et al., Cambridge, United Kingdom. In Cell Rep, 2013
Autosomal-recessive loss of the NSUN2 gene has been identified as a causative link to intellectual disability disorders in humans.
Mapping and significance of the mRNA methylome.
Preiss et al., Canberra, Australia. In Wiley Interdiscip Rev Rna, 2013
The RNA:m(5)C MTases NSUN2 and TRDMT1 have roles in tRNA methylation but they also act on mRNA.
Identification of direct targets and modified bases of RNA cytosine methyltransferases.
Cairns et al., Salt Lake City, United States. In Nat Biotechnol, 2013
When applied in a human cell line to the RNA methyltransferases DNMT2 and NSUN2, Aza-IP enabled >200-fold enrichment of tRNAs that are known targets of the enzymes.
RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis.
Lyko et al., Heidelberg, Germany. In Nat Struct Mol Biol, 2012
Steady-state levels of unmethylated tRNAs were substantially reduced, and loss of Dnmt2 and NSun2 was further associated with reduced rates of overall protein synthesis.
Mutations in NSUN2 cause autosomal-recessive intellectual disability.
Kuss et al., Berlin, Germany. In Am J Hum Genet, 2012
A deficiency in NSUN2 function causes intellectual disability in individuals homozygous for these mutations.
Mutation in NSUN2, which encodes an RNA methyltransferase, causes autosomal-recessive intellectual disability.
Vincent et al., Toronto, Canada. In Am J Hum Genet, 2012
NSUN2 localizes to the nucleolus of Purkinje cells in the cerebellum. Mutation to arginine at residue 679 causes NSUN2 to fail to localize within the nucleolus.
The RNA-methyltransferase Misu (NSun2) poises epidermal stem cells to differentiate.
Frye et al., Cambridge, United Kingdom. In Plos Genet, 2011
we identify that an RNA methyltransferase (Misu/Nsun2) is required to balance stem cell self-renewal and differentiation in skin
The tRNA methyltransferase NSun2 stabilizes p16INK⁴ mRNA by methylating the 3'-untranslated region of p16.
Wang et al., Beijing, China. In Nat Commun, 2011
findings show that NSun2, a transfer RNA methyltransferase, inhibits the turnover of p16(INK4) mRNA; conclude that NSun2-mediated methylation of the p16 3'UTR is a novel mechanism to stabilize p16 mRNA
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