Targeting Mitosis in Cancer: Emerging Strategies.
Toronto, Canada. In Mol Cell, Dec 2015
This reasoning stimulated our development of novel inhibitors targeting the critical regulators of genomic stability and the mitotic checkpoint: AURKA, PLK4, and Mps1/TTK.
Chronic centrosome amplification without tumorigenesis.
San Diego, United States. In Proc Natl Acad Sci U S A, Dec 2015
To do this, we constructed and analyzed mice in which centrosome amplification can be induced by a Cre-recombinase-mediated increase in expression of Polo-like kinase 4 (Plk4).
What next-generation sequencing (NGS) technology has enabled us to learn about primary autosomal recessive microcephaly (MCPH).
London, United Kingdom. In Mol Cell Probes, Oct 2015
The functions of proteins such as WDR62, CASC5, PHC1, CDK6, CENP-E, CENP-F, CEP63, ZNF335, PLK4 and TUBGPC, have been added to the complex network of critical cellular processes known to be involved in brain growth and size.