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Polo-like kinase 4

SAK, Plk4
This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. Three alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jun 2010] (from NCBI)
Papers using SAK antibodies
Sak serine-threonine kinase acts as an effector of Tec tyrosine kinase
Supplier
Cleveland Don W. et al., In The Journal of Cell Biology, 2000
... A fragment of mouse Plk4 (aa 223–387) encoding the appropriate mutations was synthesized (Genscript) and used to replace ...
Papers on SAK
Polo-like kinase 4 controls centriole duplication but does not directly regulate cytokinesis.
GeneRIF
Cleveland et al., San Diego, United States. In Mol Biol Cell, 2012
Plk4 is a centriole-localized kinase that does not directly regulate cytokinesis.
Cell-cycle-regulated expression of STIL controls centriole number in human cells.
GeneRIF
Nigg et al., Basel, Switzerland. In J Cell Sci, 2012
STIL cooperates with SAS-6 and PLK4 in the control of centriole number and represents a key centriole duplication factor in human cells.
The Protein Phosphatase 2A regulatory subunit Twins stabilizes Plk4 to induce centriole amplification.
GeneRIF
Rogers et al., Tucson, United States. In J Cell Biol, 2011
PP2A (Protein Phosphatase 2A(Twins)) counteracts Plk4 autophosphorylation, thus stabilizing Plk4 and promoting centriole duplication
Male hypogonadism and germ cell loss caused by a mutation in Polo-like kinase 4.
GeneRIF
Jameson et al., Chicago, United States. In Endocrinology, 2011
the I242N heterozygous mutation in PLK4 is causative for patchy germ cell loss beginning at P10, suggesting a role for PLK4 during the initiation of spermatogenesis.
The SCF-FBXW5 E3-ubiquitin ligase is regulated by PLK4 and targets HsSAS-6 to control centrosome duplication.
Impact
GeneRIF
Malek et al., Hannover, Germany. In Nat Cell Biol, 2011
The activity of SCF-FBXW5 is negatively regulated by Polo-like kinase 4 (PLK4), which phosphorylates FBXW5 at Ser 151 to suppress its ability to ubiquitylate HsSAS-6.
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