Serpin A1 C-Terminal Peptides as Collagen Turnover Modulators.
Sesto Fiorentino, Italy. In Chemmedchem, Dec 2015
Interestingly, we identified a decapeptide, termed SA1-III (Ac-MGKVVNPTQK-NH2 ), as a promising candidate for our purposes; it is able to induce a significant increase in type I collagen levels in the culture medium of treated cells at micromolar concentrations.
Increased Rat Placental Fatty Acid, But Decreased Amino Acid and Glucose Transporters Potentially Modify Intrauterine Programming.
Köln, Germany. In J Cell Biochem, Dec 2015
Gene and protein expression of placental nutrient transporters for fatty acids (h-FABP, CD36), amino acids (SNAT1, SNAT2) and glucose (GLUT-1, Connexin 26) were examined by qRT-PCR, western blot and immunohistochemistry. Interestingly, the mean protein expression of h-FABP was doubled in placentas of LIG and SOP animals 4, 24 (SOP significant) and 72 h (SOP significant) after surgery.
Triazole linked mono carbonyl curcumin-isatin bifunctional hybrids as novel anti tubulin agents: Design, synthesis, biological evaluation and molecular modeling studies.
Amritsar, India. In Bioorg Med Chem, Dec 2015
The results revealed that the compounds SA-1 to SA-9, SB-2, SB-3, SB-4, SB-7 and SC-2 showed a good range of IC50 values against THP-1, COLO-205, HCT-116 and PC-3 cell lines, while the other four cell lines among these were found to be almost resistant.
Mechanotransduction in epidermal Merkel cells.
New York City, United States. In Pflugers Arch, 2015
Merkel cell-neurite complexes mediate slowly adapting type I (SAI) responses, which encode sustained pressure and represent object features with high fidelity.
Impairment of glutamine/glutamate-γ-aminobutyric acid cycle in manganese toxicity in the central nervous system.
Cambridge, United Kingdom. In Folia Neuropathol, 2013
Manganese added directly to astrocytes induces deregulation in the expression of SNAT3, SNAT2, ASCT2 and LAT2 transporters and significantly decreases in Gln uptake mediated by the transporting Systems N and ASC, and a decrease in Gln efflux mediated by Systems N, ASC and L. Further, Mn disrupts Glu transporting systems leading to both a reduction in Glu uptake and elevation in extracellular Glu levels.
Evolutionary origin of amino acid transporter families SLC32, SLC36 and SLC38 and physiological, pathological and therapeutic aspects.
Uppsala, Sweden. In Mol Aspects Med, 2013
The most well characterized genes within these families are the vesicular inhibitory amino acid transporter (VIAAT, SLC32A1), PAT1 (SLC36A1), PAT2 (SLC36A2), PAT4 (SLC36A4), SNAT1 (SLC38A1), SNAT2 (SLC38A2), SNAT3 (SLC38A3), and SNAT4 (SLC38A4).
Neural mechanisms of tactual form and texture perception.
Baltimore, United States. In Annu Rev Neurosci, 1991
Evidence from neurophysiological and psychophysical studies in which static touch, scanning touch, and the Optacon were used indicate that the spatial acuity of the RA system may be as much as three times poorer than the SAI system, evidence that suggests that form perception is dominated by the SAI system.