gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Scaffold attachment factor B2

SAFB2
Top mentioned proteins: CAN, HAD, Estrogen Receptor, fibrillin-1, Histone
Papers on SAFB2
Scaffold attachment factor B2 (SAFB2)-null mice reveal non-redundant functions of SAFB2 compared with its paralog, SAFB1.
New
Oesterreich et al., Houston, United States. In Dis Model Mech, Sep 2015
Scaffold attachment factors SAFB1 and SAFB2 are multifunctional proteins that share >70% sequence similarity.
Tumor size, stage and grade alterations of urinary peptidome in RCC.
Magni et al., Monza, Italy. In J Transl Med, 2014
Among them, C1RL, A1AGx, ZAG2G, PGBM, MMP23, GP162, ADA19, G3P, RSPH3, DREB, NOTC2 SAFB2 and CC168 were identified.
Unravelling the RNA-Binding Properties of SAFB Proteins in Breast Cancer Cells.
Tyson-Capper et al., Ljubljana, Slovenia. In Biomed Res Int, 2014
Scaffold attachment factor B1 (SAFB1) and SAFB2 proteins are oestrogen (ER) corepressors that bind to and modulate ER activity through chromatin remodelling or interaction with the basal transcription machinery.
Genetic aberrations in imatinib-resistant dermatofibrosarcoma protuberans revealed by whole genome sequencing.
La Choi et al., Seoul, South Korea. In Plos One, 2012
Of note, we identified newly emerged 8 non-synonymous somatic mutations of the genes (ACAP2, CARD10, KIAA0556, PAAQR7, PPP1R39, SAFB2, STARD9, and ZFYVE9) in the imatinib-resistant tumor tissue.
Scaffold attachment factor B (SAFB)1 and SAFB2 cooperatively inhibit the intranuclear mobility and function of ERα.
GeneRIF
Kawata et al., Kyoto, Japan. In J Cell Biochem, 2012
Results indicate that SAFB1 and SAFB2 are crucial repressors for ERalpha dynamics in association with the nuclear matrix and that their synergistic regulation of ERalpha mobility is sufficient for inhibiting ERalpha function.
SAFB1- and SAFB2-mediated transcriptional repression: relevance to cancer.
Review
Tyson-Capper et al., Newcastle upon Tyne, United Kingdom. In Biochem Soc Trans, 2012
SAFB1 (scaffold attachment factor B1) and a second family member SAFB2, are multifunctional proteins implicated in a variety of cellular processes including cell growth, apoptosis and stress response.
Quantitative proteomic identification of the BRCA1 ubiquitination substrates.
Shiio et al., San Antonio, United States. In J Proteome Res, 2011
These include scaffold attachment factor B2 (SAFB2) and Tel2 as well as BARD1.
Low SAFB levels are associated with worse outcome in breast cancer patients.
GeneRIF
Oesterreich et al., Houston, United States. In Breast Cancer Res Treat, 2010
This study shows that low SAFB protein levels predict poor prognosis of breast cancer patients, suggesting critical functions of SAFB1 and SAFB2 in breast cancer cells.
SAFB1 mediates repression of immune regulators and apoptotic genes in breast cancer cells.
GeneRIF
Oesterreich et al., Houston, United States. In J Biol Chem, 2010
Study confirms the primary role of SAFB1/SAFB2 as corepressors and also uncovers a previously unknown role for SAFB1 in the regulation of immune genes and in estrogen-mediated repression of genes.
SAFB1's multiple functions in biological control-lots still to be done!
Oesterreich et al., Houston, United States. In J Cell Biochem, 2010
SAFB1 is part of a protein family with at least two other family members, SAFB2 and the SAFB-like transcriptional modulator SLTM.
The enzymatic activity of SR protein kinases 1 and 1a is negatively affected by interaction with scaffold attachment factors B1 and 2.
GeneRIF
Georgatsou et al., Lárisa, Greece. In Febs J, 2009
The enzymatic activity of SR protein kinases 1 and 1a is negatively affected by interaction with scaffold attachment factors B1 and 2.
Estrogen-mediated downregulation of CD24 in breast cancer cells.
Brauch et al., Stuttgart, Germany. In Int J Cancer, 2008
Histone deacetylase inhibition by Trichostatin A completely abolished the repression, but decrease of the ER alpha corepressors NCoR, LCoR, RIP140, silencing mediator of retinoid and thyroid hormone receptors, SAFB1 and SAFB2 by siRNA or overexpression of SAFB2, NCoR and silencing mediator of retinoid and thyroid hormone receptors had no effect.
No germline mutations in supposed tumour suppressor genes SAFB1 and SAFB2 in familial breast cancer with linkage to 19p.
GeneRIF
Nordling et al., Göteborg, Sweden. In Bmc Med Genet, 2007
SAFB2 is not likely to be causative of the hereditary breast cancer syndrome in west Swedish breast cancer families
Alternative RNA splicing complexes containing the scaffold attachment factor SAFB2.
Elliott et al., Newcastle upon Tyne, United Kingdom. In J Cell Sci, 2007
The scaffold attachment factor SAFB1 and its recently discovered homologue SAFB2 might provide an important link between pre-mRNA splicing, intracellular signalling and transcription.
Scaffold attachment factors SAFB1 and SAFB2: Innocent bystanders or critical players in breast tumorigenesis?
Review
GeneRIF
Oesterreich, Houston, United States. In J Cell Biochem, 2003
REVIEW: possibility that SAFB1 and SAFB2 are novel breast tumor suppressor genes, and how they might function in this role, are discussed
share on facebooktweetadd +1mail to friends