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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

BR serine/threonine kinase 1

Sad1, BRSK1, Sad1p
Top mentioned proteins: ACID, CAN, POLYMERASE, AGE, LKB1
Papers on Sad1
SUPPRESSOR OF APICAL DOMINANCE1 of Sporisorium reilianum Modulates Inflorescence Branching Architecture in Maize and Arabidopsis.
New
Schirawski et al., Aachen, Germany. In Plant Physiol, Dec 2015
By deletion analysis of cluster 19-1, the largest genomic divergence cluster in S. reilianum, we identified a secreted fungal effector responsible for S. reilianum-induced loss of apical dominance, which we named SUPPRESSOR OF APICAL DOMINANCE1 (SAD1).
Endogenous Small RNA Mediates Meiotic Silencing of a Novel DNA Transposon.
New
Stajich et al., Riverside, United States. In G3 (bethesda), Oct 2015
These small RNAs are dependent on SAD-1, an RNA-dependent RNA polymerase necessary for meiotic silencing.
UNC-16 (JIP3) Acts Through Synapse-Assembly Proteins to Inhibit the Active Transport of Cell Soma Organelles to Caenorhabditis elegans Motor Neuron Axons.
New
Miller et al., Oklahoma City, United States. In Genetics, Sep 2015
We used an unc-16 suppressor screen in Caenorhabditis elegans to discover that UNC-16 acts through CDK-5 (Cdk5) and two conserved synapse assembly proteins: SAD-1 (SAD-A Kinase), and SYD-2 (Liprin-╬▒).
Synapse-Assembly Proteins Maintain Synaptic Vesicle Cluster Stability and Regulate Synaptic Vesicle Transport in Caenorhabditis elegans.
New
Miller et al., Oklahoma City, United States. In Genetics, Sep 2015
The data further showed that the synapse-assembly proteins SYD-1, SYD-2, and SAD-1 protected SV clusters from degradation by motor proteins.
SAD1, an RNA polymerase I subunit A34.5 of rice, interacts with Mediator and controls various aspects of plant development.
Kyozuka et al., Tokyo, Japan. In Plant J, 2015
We isolated a recessive mutant named super apical dormant (sad1-1) from a suppressor screen of d14-1.
Characterizing the roles of Cryphonectria parasitica RNA-dependent RNA polymerase-like genes in antiviral defense, viral recombination and transposon transcript accumulation.
Nuss et al., Rockville, United States. In Plos One, 2013
Sequence relationships with other eukaryotic RdRPs indicated that RDR1 and RDR2 were closely related to QDE-1, an RdRP involved in RNA silencing ("quelling") in Neurospora crassa, whereas RDR3 was more closely related to the meiotic silencing gene SAD-1 in N. crassa.
Transcriptome profiling identifies ABA mediated regulatory changes towards storage filling in developing seeds of castor bean (Ricinus communis L.).
Liu et al., Kunming, China. In Cell Biosci, 2013
These genes were involved in sugar metabolism (such as glucose-6-phosphate, fructose 1,6 bis-phosphate, glycerol-3-phosphate, pyruvate kinase), lipid biosynthesis (such as ACS, ACBP, GPAT2, GPAT3, FAD2, FAD3, SAD1 and DGAT1), storage proteins synthesis (such as SGP1, zinc finger protein, RING H2 protein, nodulin 55 and cytochrome P450), and ABA biosynthesis (such as NCED1, NCED3 and beta carotene).
Protein interactions at the higher plant nuclear envelope: evidence for a linker of nucleoskeleton and cytoskeleton complex.
Review
Graumann et al., Oxford, United Kingdom. In Front Plant Sci, 2013
Following the description of SAD1/UNC84 (SUN) domain proteins in higher plants, evidence has rapidly increased that plants contain a functional linker of nucleoskeleton and cytoskeleton (LINC) complex bridging the nuclear envelope (NE).
The regulation and function of the NUAK family.
Review
Zhao et al., Taipei, Taiwan. In J Mol Endocrinol, 2013
Twelve AMPK-related kinases (ARKs; BRSK1, BRSK2, NUAK1, NUAK2, QIK, QSK, SIK, MARK1, MARK2, MARK3, MARK4, and MELK) have been identified recently.
Replication of loci influencing ages at menarche and menopause in Hispanic women: the Women's Health Initiative SHARe Study.
GeneRIF
Franceschini et al., Seattle, United States. In Hum Mol Genet, 2012
Single nucleotide polymorphism in BRSK1 is associated with the length of reproductive lifespan.
ESR1, HK3 and BRSK1 gene variants are associated with both age at natural menopause and premature ovarian failure.
Review
Chen et al., Jinan, China. In Orphanet J Rare Dis, 2011
RESULTS: Three SNPs - rs2278493 in HK3, rs2234693 in ESR1 and rs12611091 in BRSK1 - showed nominally significant association with POF.
SADB phosphorylation of gamma-tubulin regulates centrosome duplication.
Impact
GeneRIF
Carrera et al., Madrid, Spain. In Nat Cell Biol, 2009
SADB kinase activity controls centrosome homeostasis by regulating phosphorylation of gamma-tubulin.
Genome-wide association studies identify loci associated with age at menarche and age at natural menopause.
Impact
Chasman et al., Boston, United States. In Nat Genet, 2009
(in or near the gene BRSK1), 5q35.2 (in or near genes UIMC1 and HK3) and 6p24.2 (in the gene SYCP2L).
The regulation and function of mammalian AMPK-related kinases.
Review
Carling et al., London, United Kingdom. In Acta Physiol (oxf), 2009
Recently, 12 AMPK-related kinases (BRSK1, BRSK2, NUAK1, NUAK2, QIK, QSK, SIK, MARK1, MARK2, MARK3, MARK4 and MELK) were identified that are closely related by sequence homology to the catalytic domain of AMPK.
C-terminal phosphorylation of LKB1 is not required for regulation of AMP-activated protein kinase, BRSK1, BRSK2, or cell cycle arrest.
GeneRIF
Hardie et al., Dundee, United Kingdom. In J Biol Chem, 2009
STRADalpha.MO25alpha complexes containing LKB1 variants were equally effective at phosphorylating and activating AMPK, BRSK1, and BRSK2
A network of nuclear envelope membrane proteins linking centromeres to microtubules.
Impact
GeneRIF
Blobel et al., New York City, United States. In Cell, 2008
The functions of Ima1, Sad1, and Kms2 establish a means of communication between the cytoplasm and nucleus that is independent of the nuclear pore complex.
Investigating the regulation of brain-specific kinases 1 and 2 by phosphorylation.
GeneRIF
Thornton et al., London, United Kingdom. In J Biol Chem, 2008
protein phosphatase 2C is a likely candidate for catalyzing the dephosphorylation and inactivation of BRSK1/2.
Meiotic silencing by unpaired DNA.
Impact
Metzenberg et al., Stanford, United States. In Cell, 2002
A semidominant Neurospora mutant, Sad-1, fails to perform MSUD.
Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways.
Impact
Elledge et al., Houston, United States. In Science, 1996
Mutants of the Saccharomyces cerevisiae ataxia telangiectasia mutated (ATM) homolog MEC1/SAD3/ESR1 were identified that could live only if the RAD53/SAD1 checkpoint kinase was overproduced.
DNA polymerase epsilon links the DNA replication machinery to the S phase checkpoint.
Impact
Elledge et al., Houston, United States. In Cell, 1995
Unlike sad1 mutants defective for multiple cell cycle checkpoints, pol2 mutants are defective only for the S phase checkpoint and the activation of DUN1 kinase necessary for the transcriptional response to damage.
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