Senescence-associated-gene signature identifies genes linked to age, prognosis, and progression of human gliomas.
Tampa, United States. In J Geriatr Oncol, 2014
GeneChip, for expression of fourteen senescence-associated genes: CCL2, CCL7, CDKN1A, COPG, CSF2RB, CXCL1, ICAM-1, IGFBP-3, IL-6, IL-8, SAA4, TNFRSF-11B, TNFSF-11 and TP53.
Serum amyloid A and pairing formyl peptide receptor 2 are expressed in corneas and involved in inflammation-mediated neovascularization.
Qingdao, China. In Int J Ophthalmol, 2013
On the contrary, other SAA members (Saa2, Saa4), other SAA receptors (Tlr2, Tlr4, Cd36, P2rx7, etc), or other Mmps (Mmp1a, Mmp1b, Mmp9, Mmp10, Mmp13) did not show consistent changes.
Reduced apolipoprotein glycosylation in patients with the metabolic syndrome.
Sioux Falls, United States. In Plos One, 2013
RESULTS: Metabolic syndrome patients differed from healthy controls in the following ways: (1) total plasma--apoA1 was lower, whereas apoB, apoC2, apoC3, and apoE were higher; (2) VLDL--apoB, apoC3, and apoE were increased; (3) LDL--apoC3 was increased, (4) HDL--associated constitutive serum amyloid A protein (SAA4) was reduced (p<0.05 vs. controls for all).
Discovery of Inverse Agonists for the Liver Receptor Homologue-1 (LRH1; NR5A2)
Bethesda, United States. In Unknown Journal, 2010
We pursued a Center-based Initiative with transfection studies testing the ability of various chemical scaffolds to inhibit LRH-1-mediated activation of the Cyp19-Aromatase-luciferase and the StAR-luciferase reporter, followed by counterscreening against SF-1 and VP16, as well as studies examining the effect of compounds on LRH-1 modulation of the APR markers haptoglobin and serum amyloid A1 and A4 (SAA1 and SAA4).