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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Perilipin 4

S3-12, PLIN4
Members of the perilipin family, such as PLIN4, coat intracellular lipid storage droplets (Wolins et al., 2003 [PubMed 12840023]).[supplied by OMIM, Feb 2010] (from NCBI)
Top mentioned proteins: Perilipin, ADRP, TIP47, ACID, Insulin
Papers on S3-12
Combined assessment of polymorphisms in the LHCGR and FSHR genes predict chance of pregnancy after in vitro fertilization.
New
Giwercman et al., Malmö, Sweden. In Hum Reprod, Feb 2016
Higher pregnancy rates were also evident for women carrying LHCGR S312, regardless of FSHR variant (OR = 1.61, 95% CI: [1.13, 2.29], P = 0.008).
Effect of Interaction between PLIN Gene Polymorphisms and Open Lifestyle Intervention on Weight-loss in Chinese Han Adults.
New
Chang et al., Beijing, China. In Zhongguo Yi Xue Ke Xue Yuan Xue Bao, Jan 2016
Anthropometric and metabolic indicators were measured for all subjects before and after intervention,and the PLIN1,PLIN4,and PLIN6 genotypes were amplified by polymerase chain reaction and sequenced through the first-generation sequencing technologies.
Tobacco Smoke Exposure Impairs Brain Insulin/IGF Signaling: Potential Co-Factor Role in Neurodegeneration.
New
de la Monte et al., Providence, United States. In J Alzheimers Dis, Jan 2016
In addition, relative levels of S312-IRS-1, which inhibits downstream signaling, were increased in the CS4, CS8, and CS8+R groups.
Olanzapine promotes the accumulation of lipid droplets and the expression of multiple perilipins in human adipocytes.
New
Itabe et al., Tokyo, Japan. In Biochem Biophys Res Commun, Dec 2015
Proteomic analysis revealed that PLIN4 and several enzymes for lipid metabolism were increased in the hMSCs after olanzapine treatment.
Pathophysiology of lipid droplet proteins in liver diseases.
Review
New
Ahima et al., Philadelphia, United States. In Exp Cell Res, Nov 2015
Five proteins of the perilipin (PLIN) family (PLIN1 (perilipin), PLIN2 (adipose differentiation-related protein), PLIN3 (tail-interacting protein of 47kDa), PLIN4 (S3-12), and PLIN5 (myocardial lipid droplet protein)), are associated with LD formation.
[Lipid droplet-associated proteins : Importance in steatosis, steatohepatitis and hepatocarcinogenesis].
Review
New
Straub, Heidelberg, Germany. In Pathologe, Oct 2015
The lipid droplet (LD)-associated proteins perilipin, adipophilin, TIP47 ("tail interacting protein of 47 kDa"), S3-12 and myocardial LD protein (MLDP), so-called perilipins 1-5 (PAT family) govern formation, maintenance and degradation of LDs.
Perilipin 4 in human skeletal muscle: localization and effect of physical activity.
New
Norheim et al., Oslo, Norway. In Physiol Rep, Aug 2015
PLIN4 mRNA exhibited the highest expression of all five PLINs in both tissues, and the expression was significantly reduced after long-term exercise in skeletal muscle.
Role of Runx2 phosphorylation in prostate cancer and association with metastatic disease.
New
Franceschi et al., Ann Arbor, United States. In Oncogene, May 2015
During bone development, Runx2 is activated by signals known to be hyperactive in PCa including the RAS/MAP kinase pathway, which phosphorylates Runx2 on multiple serine residues including S301 and S319 (equivalent to S294 and S312 in human Runx2).
Whole genome and transcriptome sequencing of matched primary and peritoneal metastatic gastric carcinoma.
Yu et al., Shanghai, China. In Sci Rep, 2014
We identified 27 mutated genes, of which 19 genes are reported in COSMIC database (ZNF208, CRNN, ATXN3, DCTN1, RP1L1, PRB4, PRB1, MUC4, HS6ST3, MUC17, JAM2, ITGAD, IREB2, IQUB, CORO1B, CCDC121, AKAP2, ACAN and ACADL), and eight genes have not previously been described in gastric cancer (CCDC178, ARMC4, TUBB6, PLIN4, PKLR, PDZD2, DMBT1and DAB1).Additionally,GPX4 and MPND in 19q13.3-13.4
Expression analysis of human adipose-derived stem cells during in vitro differentiation to an adipocyte lineage.
Rubin et al., Pittsburgh, United States. In Bmc Med Genomics, 2014
In addition to confirming differential expression of known markers of adipogenesis (e.g., FABP4, ADIPOQ, PLIN4), multiple genes and signaling pathways not previously known to be involved in regulating adipogenesis were identified (e.g.
On the formation of lipid droplets in human adipocytes: the organization of the perilipin-vimentin cortex.
Franke et al., Heidelberg, Germany. In Plos One, 2013
Using these cells and highly specific antibodies for LD-binding proteins of the perilipin (PLIN) family, we could distinguish between endogenously derived LDs (endogenous LDs) positive for perilipin from exogenously induced LDs (exogenous LDs) positive for adipophilin, TIP47 and S3-12.
Perilipin family (PLIN) proteins in human skeletal muscle: the effect of sex, obesity, and endurance training.
GeneRIF
Tarnopolsky et al., Canada. In Appl Physiol Nutr Metab, 2012
PLIN2-PLIN5 proteins were all more abundant in women than in men (p = 0.037 and p < 0.0001, respectively), consistent with higher intramyocellular lipid content observed in female skeletal muscle.
A Polymorphism in a gene encoding Perilipin 4 is associated with height but not with bone measures in individuals from the Framingham Osteoporosis Study.
GeneRIF
Ordovas et al., Boston, United States. In Calcif Tissue Int, 2012
we found a significant association between one single-nucleotide polymorphism in PLIN4 and height but not with bone traits
Role of lipid droplet proteins in liver steatosis.
Review
Okumura, Asahikawa, Japan. In J Physiol Biochem, 2011
Five proteins of the perilipin (Plin) family such as Plin1 (perilipin) Plin2 (adipose differentiation-related protein), Plin3 (tail-interacting protein of 47 kDa), Plin4 (S3-12), and Plin5 (myocardial lipid droplet protein) are characterized as lipid droplet (LD) proteins in adipocytes.
Lipid droplet associated proteins: an emerging role in atherogenesis.
Review
Robenek et al., Münster, Germany. In Histol Histopathol, 2011
However, only more recently has it become apparent that a special set of lipid droplet associated proteins - the PAT protein family (perilipin, adipophilin, TIP47, S3-12 and OXPAT) - is fundamental to the formation, growth, stabilization and functions of lipid droplets.
The PLIN4 variant rs8887 modulates obesity related phenotypes in humans through creation of a novel miR-522 seed site.
GeneRIF
Ordovas et al., Boston, United States. In Plos One, 2010
These results suggest variation at the PLIN4 locus, and its interaction with PUFA as a modulator of obesity related phenotypes, acts in part through creation of a miR-522 regulatory site
Association of lifestyle factors, polymorphisms in adiponectin, perilipin and hormone sensitive lipase, and clinical markers in Japanese males.
GeneRIF
Otsuka et al., Tokyo, Japan. In J Nutr Sci Vitaminol (tokyo), 2009
Those findings indicate improvement and conservation of lifestyle depending on genetic predisposition in ADIPOQ, PLIN and LIPE should be encouraged.
PAT proteins, an ancient family of lipid droplet proteins that regulate cellular lipid stores.
Review
Welte et al., Houston, United States. In Biochim Biophys Acta, 2009
The PAT family of lipid droplet proteins includes 5 members in mammals: perilipin, adipose differentiation-related protein (ADRP), tail-interacting protein of 47 kDa (TIP47), S3-12, and OXPAT.
S3-12, Adipophilin, and TIP47 package lipid in adipocytes.
GeneRIF
Bickel et al., Saint Louis, United States. In J Biol Chem, 2005
the non-lipid droplet pools of S3-12, adipophilin, and TIP47 constitute a ready reservoir of coat proteins to permit rapid packaging of newly synthesized triacylglycerol and to maximize energy storage during nutrient excess
Cloning of cell-specific secreted and surface proteins by subtractive antibody screening.
Impact
Lodish et al., Cambridge, United States. In Nat Biotechnol, 1998
We describe several of these, including a novel plasma membrane-associated protein, S3-12.
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