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Sphingosine-1-phosphate receptor 4

S1P4, LPC-1, Edg-6
This gene is a member of the endothelial differentiation, G-protein-coupled (EDG)) receptor gene family. EDG receptors bind lysophospholipids or lysosphingolipids as ligands, and are involved in cell signalling in many different cell types. This EDG receptor gene is intronless and is specifically expressed in the lymphoid tissue. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: S1P1, S1P3, S1P2, S1P5, V1a
Papers on S1P4
Sphingosine-1-phosphate receptor antagonism enhances proliferation and migration of engrafted neural progenitor cells in a model of viral-induced demyelination.
New
Lane et al., Salt Lake City, United States. In Am J Pathol, Oct 2015
The oral drug FTY720 affects sphingosine-1-phosphate (S1P) signaling on targeted cells that bear the S1P receptors S1P1, S1P3, S1P4, and S1P5.
Role of sphingosine 1-phosphate receptors, sphingosine kinases and sphingosine in cancer and inflammation.
Review
New
Pyne et al., Bologna, Italy. In Adv Biol Regul, Oct 2015
S1P4) and SK1 in cancer, where high expression of these proteins in ER negative breast cancer patient tumours is linked with poor prognosis.
Sphingosine 1-Phosphate Receptor 3-Deficient Dendritic Cells Modulate Splenic Responses to Ischemia-Reperfusion Injury.
New
Okusa et al., Charlottesville, United States. In J Am Soc Nephrol, Sep 2015
Sphingosine 1-phosphate (S1P) is a sphingolipid and the natural ligand for five G protein-coupled receptors (S1P1, S1P2, S1P3, S1P4, and S1P5), and S1PR agonists reduce kidney ischemia-reperfusion injury (IRI) in mice.
Lysophosphatidic acid stimulates cell migration of satellite cells. A role for the sphingosine kinase/sphingosine 1-phosphate axis.
Donati et al., Florence, Italy. In Febs J, 2014
Moreover, the LPA-dependent stimulation of cell chemotaxis was found to be impaired by down-regulation of the sphingosine 1-phosphate (S1P) receptors S1P1 or S1P4 by specific siRNAs.
Sphingosine-1-phosphate receptors control B-cell migration through signaling components associated with primary immunodeficiencies, chronic lymphocytic leukemia, and multiple sclerosis.
Eibel et al., Freiburg, Germany. In J Allergy Clin Immunol, 2014
RESULTS: Showing that different B-cell populations express different combinations of S1P receptors, we found that S1P1 promotes migration, whereas S1P4 modulates and S1P2 inhibits S1P1 signals.
TNF-α production in NKT cell hybridoma is regulated by sphingosine-1-phosphate: implications for inflammation in atherosclerosis.
Fujii et al., Sapporo, Japan. In Coron Artery Dis, 2014
RESULTS: Hybridomas expressed S1P receptors, S1P1, S1P2, and S1P4.
Sphingosine kinase 2 prevents the nuclear translocation of sphingosine 1-phosphate receptor-2 and tyrosine 416 phosphorylated c-Src and increases estrogen receptor negative MDA-MB-231 breast cancer cell growth: The role of sphingosine 1-phosphate receptor-4.
Pyne et al., Glasgow, United Kingdom. In Cell Signal, 2014
Treatment of HA-S1P2 over-expressing MDA-MB-231 cells with the sphingosine 1-phosphate receptor-4 (S1P4) antagonist CYM50367 or with S1P4 siRNA also promoted nuclear translocation of HA-tagged S1P2.
An mRNA atlas of G protein-coupled receptor expression during primary human monocyte/macrophage differentiation and lipopolysaccharide-mediated activation identifies targetable candidate regulators of inflammation.
Sweet et al., Brisbane, Australia. In Immunobiology, 2013
For example, EDG1 was expressed at elevated levels in CSF-1 Mϕ versus GM-CSF Mϕ, whereas the reverse was true for EDG6.
TGFβ1 evokes myoblast apoptotic response via a novel signaling pathway involving S1P4 transactivation upstream of Rho-kinase-2 activation.
Bruni et al., Florence, Italy. In Faseb J, 2013
Herein we report the identification of a new signaling pathway, relying on Rho kinase-2 stimulation, subsequent to SMAD-dependent S1P4 up-regulation and transactivation via sphingosine kinase (SK)-2, that accounts for TGFβ1-induced apoptosis in cultured myoblasts.
Fingolimod: direct CNS effects of sphingosine 1-phosphate (S1P) receptor modulation and implications in multiple sclerosis therapy.
Review
Chun et al., Los Angeles, United States. In J Neurol Sci, 2013
Following phosphorylation in vivo, the active agent, fingolimod phosphate (fingolimod-P), acts as a sphingosine 1-phosphate (S1P) receptor modulator, binding with high affinity to four of the five known S1P receptors (S1P1, S1P3, S1P4 and S1P5).
Expression of sphingosine 1-phosphate receptor 4 and sphingosine kinase 1 is associated with outcome in oestrogen receptor-negative breast cancer.
GeneRIF
Edwards et al., Glasgow, United Kingdom. In Br J Cancer, 2012
findings highlight an important role for S1P(4) and SK1 in ER(-) breast cancer progression.
Discovery, design and synthesis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P₄-R) agonists.
GeneRIF
Roberts et al., Los Angeles, United States. In Bioorg Med Chem Lett, 2012
analysis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P-R) agonists
Sphingosine 1-phosphate receptor 1 as a useful target for treatment of multiple sclerosis.
Adachi et al., Yokohama, Japan. In Pharmaceuticals (basel), 2011
FTY720-P shows high affinity to 4 of the S1P receptors (S1P1, S1P3, S1P4, and S1P5).
Sphingosine-1-phospate receptor 4 (S1P₄) deficiency profoundly affects dendritic cell function and TH17-cell differentiation in a murine model.
GeneRIF
Lipp et al., Berlin, Germany. In Faseb J, 2011
S1P4 signaling is involved in the regulation of dendritic cell function and TH17 T-cell differentiation. S1P4-mediated S1P signaling also modifies the course of various immune diseases in a murine model
Probe Development Efforts for an Allosteric Agonist of the Sphingosine 1-phosphate Receptor 3 (S1P3)
Review
Rosen et al., Bethesda, United States. In Unknown Journal, 2011
ML249 activates S1P3 receptor with an EC50 of 72.3 nM–132 nM, and is inactive as an agonist against other members of the receptor family S1P1 (EC50 >10 μM), S1P2 (EC50 >50 μM), S1P4 (EC50 >50 μM), and S1P5 (EC50 >25 μM).
Discovery of AMG 369, a Thiazolo[5,4-b]pyridine Agonist of S1P1 and S1P5.
Bürli et al., Thousand Oaks, United States. In Acs Med Chem Lett, 2011
These efforts resulted in the discovery of 1-(3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo-[5,4-b]pyridin-2-yl)benzyl)azetidine-3-carboxylic acid (5d, AMG 369), a potent dual S1P1/S1P5 agonist with limited activity at S1P3 and no activity at S1P2/S1P4.
Shaping of terminal megakaryocyte differentiation and proplatelet development by sphingosine-1-phosphate receptor S1P4.
GeneRIF
Lipp et al., Berlin, Germany. In Faseb J, 2010
Megakaryocytes generated from S1P(4)-deficient murine bone marrow showed atypical and reduced formation of proplatelets in vitro.
Sphingosine 1-phosphate receptor 4 uses HER2 (ERBB2) to regulate extracellular signal regulated kinase-1/2 in MDA-MB-453 breast cancer cells.
GeneRIF
Pyne et al., Glasgow, United Kingdom. In J Biol Chem, 2010
Data show that S1P4 uses HER2 to regulate extracellular signal regulated kinase-1/2 MDA-MB-453 breast cancer cells.
Probe Development Efforts to Identify Novel Agonists of the Sphingosine 1-phosphate Receptor 4 (S1P4)
Review
Rosen et al., Bethesda, United States. In Unknown Journal, 2010
S1P4 receptor is coupled to Gαi and Gαo G proteins and activates extracellular-signal-regulated kinases (ERK), Mitogen-activated protein kinases (MAPK) and Phospholipase C (PLC) downstream pathways.
Identification of a Novel Agonist of the Sphingosine 1-phosphate Receptor 4 (S1P4)
Review
Roberts et al., Bethesda, United States. In Unknown Journal, 0001
S1P4 receptor is coupled to Gαi and Gαo G proteins and activates extracellular signal-regulated kinases (ERK) mitogen-activated protein kinases (MAPK) and Phospholipase C (PLC) downstream pathways.
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