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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Sphingosine-1-phosphate receptor 3

S1P3, Edg-3
This gene encodes a member of the EDG family of receptors, which are G protein-coupled receptors. This protein has been identified as a functional receptor for sphingosine 1-phosphate and likely contributes to the regulation of angiogenesis and vascular endothelial cell function. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: S1P1, S1P2, V1a, ACID, S1P5
Papers on S1P3
Deletion of sphingosine kinase 1 ameliorates hepatic steatosis in diet-induced obese mice: Role of PPARγ.
Xia et al., Sydney, Australia. In Biochim Biophys Acta, Feb 2016
In contrast, the siRNA-mediated knockdown of SphK1 or S1P receptors, S1P2 and S1P3, profoundly inhibited lipid accumulation in hepatocytes.
Late-stage optimization of a tercyclic class of S1P3-sparing, S1P1 receptor agonists.
Lemieux et al., United States. In Bioorg Med Chem Lett, Feb 2016
Poor solubility and cationic amphiphilic drug-likeness were liabilities identified for a lead series of S1P3-sparing, S1P1 agonists originally developed from a high-throughput screening campaign.
Sphingosine-1-Phosphate reduces ischemia/reperfusion injury by phosphorylating the gap junction protein Connexin43.
Kwak et al., Copenhagen, Denmark. In Cardiovasc Res, Feb 2016
Mechanistic in vitro and ex vivo studies revealed that 5 min of S1P treatment induced phosphorylation of the gap junction protein Connexin43 (Cx43) on Serine368, which was mediated by S1P2 and S1P3, but not by S1P1, receptors in cardiomyocytes.
Discovery of tetrahydro-pyrazolo-pyridine as sphingosine 1-phosphate receptor 3 (S1P3)-sparing S1P1 agonists active at low oral doses.
Witherington et al., In J Med Chem, Feb 2016
It is a potent agonist of the S1P1 receptor but its lack of selectivity against the S1P3 receptor has been linked to most of the cardiovascular side effects observed in the clinic.
S1P3 receptor influences key physiological properties of fast-twitch extensor digitorum longus muscle.
Danieli-Betto et al., Padova, Italy. In J Appl Physiol, Jan 2016
UNASSIGNED: To examine the role of sphingosine 1-phosphate (S1P) receptor 3 (S1P3) in modulating muscle properties, we utilized transgenic mice depleted of the receptor.
Azacyclic FTY720 Analogues That Limit Nutrient Transporter Expression but Lack S1P Receptor Activity and Negative Chronotropic Effects Offer a Novel and Effective Strategy to Kill Cancer Cells in Vivo.
Hanessian et al., Montréal, Canada. In Acs Chem Biol, Jan 2016
Of importance is that these compounds fail to activate S1P1 or S1P3 receptors in vivo but retain inhibitory effects on nutrient transporter proteins and anticancer activity in solid tumor xenograft models.
Signal transduction by HDL: agonists, receptors, and signaling cascades.
Nofer, Münster, Germany. In Handb Exp Pharmacol, 2014
Several HDL-associated receptor ligands such as apolipoprotein A-I (apoA-I) or sphingosine-1-phosphate (S1P) have been identified in addition to HDL holoparticles, which interact with surface receptors such as ATP-binding cassette transporter A1 (ABCA1); S1P receptor types 1, 2, and 3 (S1P1, S1P2, and S1P3); or scavenger receptor type I (SR-BI) and activate intracellular signaling cascades encompassing kinases, phospholipases, trimeric and small G-proteins, and cytoskeletal proteins such as actin or junctional protein such as connexin43.
Sphingosine kinase 1/sphingosine 1-phosphate signalling pathway as a potential therapeutic target of pulmonary hypertension.
Yang et al., Kunming, China. In Int J Clin Exp Med, 2014
The S1P receptors S1P1 and S1P3 promote, while S1P2 inhibits VSMC proliferation and migration in vitro in response to S1P.
Sphingosine lysolipids in the CNS: endogenous cannabinoid antagonists or a parallel pain modulatory system?
Sim-Selley et al., Richmond, United States. In Life Sci, 2013
In contrast, S1P acting peripherally at S1P1 and S1P3 receptors can enhance sensitivity to various pain stimuli or elicit spontaneous pain.
Dendritic cell sphingosine 1-phosphate receptor-3 regulates Th1-Th2 polarity in kidney ischemia-reperfusion injury.
Okusa et al., Charlottesville, United States. In J Immunol, 2012
Mice deficient in bone marrow (BM) S1P3 are protected from kidney ischemia-reperfusion injury and have reduced infiltration of natural killer (NK)T cells and neutrophils, compared with mice with wild-type BM cells.
Sphingosine-1-phosphate receptor-3 signaling up-regulates epidermal growth factor receptor and enhances epidermal growth factor receptor-mediated carcinogenic activities in cultured lung adenocarcinoma cells.
Lee et al., Detroit, United States. In Int J Oncol, 2012
Suggest that the enhanced S1P3-EGFR signaling axis may contribute to the tumorigenesis or progression of lung adenocarcinomas.
Sphingosine-1-phosphate receptor 3 promotes neointimal hyperplasia in mouse iliac-femoral arteries.
Daum et al., Seattle, United States. In Arterioscler Thromb Vasc Biol, 2012
S1PR3 promoted neointimal hyperplasia on denudation of iliac-femoral arteries in mice, likely by stimulating cell migration and proliferation through activation of signaling pathways involving Erk, Akt, and Rac.
Differential expression of sphingosine-1-phosphate receptors in abdominal aortic aneurysms.
Cheng et al., Hong Kong, Hong Kong. In Mediators Inflamm, 2011
abdominal aortic aneurysms have down-regulation of the S1P2 protein with simultaneous up-regulation of the S1P3 protein, but not S1P1
Probe Development Efforts for an Allosteric Agonist of the Sphingosine 1-phosphate Receptor 3 (S1P3)
Rosen et al., Bethesda, United States. In Unknown Journal, 2011
S1P3 receptor couples promiscuously to Gi, Gq, and G12/13 proteins, and its tissue distribution is widespread.
Sphingosine kinase 1 and sphingosine 1-phosphate receptor 3 are functionally upregulated on astrocytes under pro-inflammatory conditions.
Pouly et al., Genève, Switzerland. In Plos One, 2010
the SphK1/S1P(3) signaling axis is upregulated when astrocytes are activated by LPS
Dendritic cell PAR1-S1P3 signalling couples coagulation and inflammation.
Ruf et al., Los Angeles, United States. In Nature, 2008
demonstration of a critical role for dendritic cell PAR1-S1P3 cross-talk in regulating amplification of inflammation in sepsis syndrome
Follicular shuttling of marginal zone B cells facilitates antigen transport.
Cyster et al., San Francisco, United States. In Nat Immunol, 2008
Migration to the follicle required the chemokine receptor CXCR5, whereas return to the marginal zone was promoted by the sphingosine 1-phosphate receptors S1P1 and S1P3.
CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs.
Matloubian et al., San Francisco, United States. In Nature, 2006
CD69 co-immunoprecipitated with S1P1 but not the related receptor, S1P3.
Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate.
Hla et al., Farmington, United States. In Cell, 1999
Both EDG-1-and EDG-3-regulated signaling pathways are required for endothelial cell morphogenesis into capillary-like networks.
Identification of a Novel Agonist of the Sphingosine 1-phosphate Receptor 4 (S1P4)
Roberts et al., Bethesda, United States. In Unknown Journal, 0001
ML248 activates S1P4 receptor with a half maximal effective concentration (EC50) of 37.7 nM–79.1 nM, and is inactive as an agonist against other members of the receptor family, with EC50s > 25 μM against S1P1, S1P2, and S1P3 receptors, and an EC50 of 2.1 μM against the S1P5 receptor.
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