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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Sphingosine-1-phosphate receptor 1

S1P1, Edg-1, S1P receptor, sphingosine-1-phosphate receptor
The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: V1a, S1P3, CAN, S1P2, sphingosine kinase
Papers on S1P1
Sphingosine-1-Phosphate reduces ischemia/reperfusion injury by phosphorylating the gap junction protein Connexin43.
Kwak et al., Copenhagen, Denmark. In Cardiovasc Res, Feb 2016
Mechanistic in vitro and ex vivo studies revealed that 5 min of S1P treatment induced phosphorylation of the gap junction protein Connexin43 (Cx43) on Serine368, which was mediated by S1P2 and S1P3, but not by S1P1, receptors in cardiomyocytes.
Discovery of tetrahydro-pyrazolo-pyridine as sphingosine 1-phosphate receptor 3 (S1P3)-sparing S1P1 agonists active at low oral doses.
Witherington et al., In J Med Chem, Feb 2016
It is a potent agonist of the S1P1 receptor but its lack of selectivity against the S1P3 receptor has been linked to most of the cardiovascular side effects observed in the clinic.
The hematopoietic oncoprotein FOXP1 promotes tumor cell survival in diffuse large B-cell lymphoma by repressing S1PR2 signaling.
Müller et al., Zürich, Switzerland. In Blood, Feb 2016
We find that the sphingosine-1-phosphate receptor 2 (S1PR2) is repressed by FOXP1 in activated B-cell (ABC) and germinal center B-cell (GCB) DLBCL cell lines with aberrantly high FOXP1 levels; S1PR2 expression is further inversely correlated with FOXP1 expression in three patient cohorts.
Ponesimod, a selective S1P1 receptor modulator: a potential treatment for multiple sclerosis and other immune-mediated diseases.
Prinz et al., Basel, Switzerland. In Ther Adv Chronic Dis, Jan 2016
The first oral treatment for relapsing multiple sclerosis, the nonselective sphingosine-1-phosphate receptor (S1PR) modulator fingolimod, led to identification of a pivotal role of sphingosine-1-phosphate and one of its five known receptors, S1P1R, in regulation of lymphocyte trafficking in multiple sclerosis.
Elevated Nuclear and Cytoplasmic FTY720-Phosphate in Mouse Embryonic Fibroblasts Suggests the Potential for Multiple Mechanisms in FTY720-Induced Neural Tube Defects.
Gelineau-van Waes et al., Omaha, United States. In Toxicol Sci, Jan 2016
Cytoplasmic FTY720-P is an agonist for four of the five sphingosine-1-phosphate (S1P) receptors (S1P1, 3-5) and can also act as a functional antagonist of S1P1, whereas FTY720-P generated in the nucleus inhibits histone deacetylases (HDACs), leading to increased histone acetylation.
Pharmacology of bile acid receptors: Evolution of bile acids from simple detergents to complex signaling molecules.
Li et al., East Lansing, United States. In Pharmacol Res, Jan 2016
Ultimately, seminal studies by many investigators led to the discovery of several bile acid-activated receptors including the farnesoid X receptor, the vitamin D receptor, the pregnane X receptor, TGR5, α5 β1 integrin, and sphingosine-1-phosphate receptor 2. Several of these receptors are expressed outside of the gastrointestinal system, indicating that bile acids may have diverse functions throughout the body.
Exit Strategies: S1P Signaling and T Cell Migration.
Schwab et al., New York City, United States. In Trends Immunol, Dec 2015
Whereas the role of sphingosine 1-phosphate receptor 1 (S1PR1) in T cell egress and the regulation of S1P gradients between lymphoid organs and circulatory fluids in homeostasis are increasingly well understood, much remains to be learned about S1P signaling and distribution during an immune response.
The role of epidermal sphingolipids in dermatologic diseases.
Cudnoch-Jedrzejewska et al., Warsaw, Poland. In Lipids Health Dis, Dec 2015
A recent clinical study of the efficacy and safety of ponesimod (a selective modulator of the S1P receptor 1) suggested that sphingolipid metabolism may become a new target for the pharmacological treatment of psoriasis.
HDL-bound sphingosine-1-phosphate restrains lymphopoiesis and neuroinflammation.
Hla et al., New York City, United States. In Nature, Aug 2015
Here we show that ApoM-S1P is dispensable for lymphocyte trafficking yet restrains lymphopoiesis by activating the S1P1 receptor on bone marrow lymphocyte progenitors.
Bile acids and sphingosine-1-phosphate receptor 2 in hepatic lipid metabolism.
Zhou et al., Richmond, United States. In Acta Pharm Sin B, Mar 2015
Recent studies identified a new signaling pathway by which conjugated bile acids (CBA) activate the extracellular regulated protein kinases (ERK1/2) and protein kinase B (AKT) signaling pathway via sphingosine-1-phosphate receptor 2 (S1PR2).
Loss of signalling via Gα13 in germinal centre B-cell-derived lymphoma.
Cyster et al., San Francisco, United States. In Nature, 2015
Work in mice showed that sphingosine-1-phosphate receptor-2 (S1PR2), a Gα12 and Gα13 coupled receptor, promotes growth regulation and local confinement of germinal centre B cells.
Sphingosine kinase 1/sphingosine 1-phosphate signalling pathway as a potential therapeutic target of pulmonary hypertension.
Yang et al., Kunming, China. In Int J Clin Exp Med, 2014
S1P has been shown to regulate VSMC proliferation and migration and vascular tension via a family of five S1P G-protein-coupled receptors (S1P1-SIP5).
S1P-Dependent trafficking of intracellular yersinia pestis through lymph nodes establishes Buboes and systemic infection.
Abraham et al., Singapore, Singapore. In Immunity, 2014
Retention of multiple subsets of phagocytes within peripheral LNs using the S1P receptor agonist FTY720 or S1P1-specific agonist SEW2871 increased survival, reduced colonization of downstream LNs, and limited progression to transmission-associated septicemic or pneumonic disease states.
Transcriptional downregulation of S1pr1 is required for the establishment of resident memory CD8+ T cells.
Jameson et al., Minneapolis, United States. In Nat Immunol, 2013
We found that CD8(+) T(RM) cells lacked expression of the transcription factor KLF2 and its target gene S1pr1 (which encodes S1P1, a receptor for sphingosine 1-phosphate).
Defective sphingosine 1-phosphate receptor 1 (S1P1) phosphorylation exacerbates TH17-mediated autoimmune neuroinflammation.
Han et al., Stanford, United States. In Nat Immunol, 2013
However, alternative mechanisms of S1P-S1P1 signaling have been reported.
Sphingosine-1-phosphate receptor-1 controls venous endothelial barrier integrity in zebrafish.
Presta et al., Brescia, Italy. In Arterioscler Thromb Vasc Biol, 2012
Report role for S1PR1 in regulation venous endothelial barrier function.
S1PR1 is an effective target to block STAT3 signaling in activated B cell-like diffuse large B-cell lymphoma.
Yu et al., Duarte, United States. In Blood, 2012
Persistent activated STAT3 colocalizes with elevated expression of S1PR1, a G-protein-coupled receptor for sphingosine-1-phosphate (S1P), in the tumor cells of the activated B cell-like subtype of diffuse large B-cell lymphoma.
Proximal cerebral arteries develop myogenic responsiveness in heart failure via tumor necrosis factor-α-dependent activation of sphingosine-1-phosphate signaling.
Bolz et al., Toronto, Canada. In Circulation, 2012
Proximal cerebral arteries develop myogenic responsiveness in heart failure via tumor necrosis factor-alpha-dependent activation of sphingosine-1-phosphate signaling.
Sphingosine 1-phosphate receptor activation enhances BMP-2-induced osteoblast differentiation.
Sano et al., Nishinomiya, Japan. In Biochem Biophys Res Commun, 2012
These results indicate that S1P receptor-mediated signaling plays a crucial role for osteoblast differentiation.
S1PR1-STAT3 signaling is crucial for myeloid cell colonization at future metastatic sites.
Yu et al., Duarte, United States. In Cancer Cell, 2012
Demonstrate that S1PR1-STAT3 signalling enables myeloid cells to intravasate, prime the distant organ microenvironment and mediate sustained proliferation and survival of their own and other stromal cells at future metastatic sites.
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