Pharmacology of bile acid receptors: Evolution of bile acids from simple detergents to complex signaling molecules.
East Lansing, United States. In Pharmacol Res, Jan 2016
Ultimately, seminal studies by many investigators led to the discovery of several bile acid-activated receptors including the farnesoid X receptor, the vitamin D receptor, the pregnane X receptor, TGR5, α5 β1 integrin, and sphingosine-1-phosphate receptor 2. Several of these receptors are expressed outside of the gastrointestinal system, indicating that bile acids may have diverse functions throughout the body.
Exit Strategies: S1P Signaling and T Cell Migration.
New York City, United States. In Trends Immunol, Dec 2015
Whereas the role of sphingosine 1-phosphate receptor 1 (S1PR1) in T cell egress and the regulation of S1P gradients between lymphoid organs and circulatory fluids in homeostasis are increasingly well understood, much remains to be learned about S1P signaling and distribution during an immune response.
The role of epidermal sphingolipids in dermatologic diseases.
Warsaw, Poland. In Lipids Health Dis, Dec 2015
A recent clinical study of the efficacy and safety of ponesimod (a selective modulator of the S1P receptor 1) suggested that sphingolipid metabolism may become a new target for the pharmacological treatment of psoriasis.