Cost effectiveness of newborn screening for cystic fibrosis: A simulation study.
Québec, Canada. In J Cyst Fibros, 12 Dec 2013
NBS simulated options were based on a combination of tests between the two commonly used immunoreactive trypsinogen (IRT) cutoffs (96th percentile and 99.5th percentile) as first tier tests, and, as a second tier test, either a second IRT, pancreatic-associated protein (PAP) or CFTR mutation panels.
Molecular diagnosis of prostate cancer: are we up to age?
Philadelphia, United States. In Semin Oncol, Jun 2013
Historically used biomarkers such as prostatic acid phosphatase (PAP), serum prostate-specific antigen (PSA), and its precursor have not stood the challenge of sensitivity and specificity.
The novel poly(A) polymerase Star-PAP is a signal-regulated switch at the 3'-end of mRNAs.
Madison, United States. In Adv Biol Regul, Jan 2013
We have discovered a novel nuclear poly(A) polymerase termed Star-PAP (nuclear speckle targeted PIPKIα regulated-poly(A) polymerase) that couples with the transcriptional machinery and is regulated by the phosphoinositide lipid messenger phosphatidylinositol-4,5-bisphosphate (PI4,5P(2)), the central lipid in phosphoinositide signaling.
Emerging Roles of Human Prostatic Acid Phosphatase.
South Korea. In Biomol Ther (seoul), Jan 2013
Prostatic acid phosphatase (PAP) is a non-specific phosphomonoesterase synthesized in prostate epithelial cells and its level proportionally increases with prostate cancer progression.
A PtdIns4,5P2-regulated nuclear poly(A) polymerase controls expression of select mRNAs.
More papers using
Madison, United States. In Nature, 2008
Here we show that PIPKIalpha co-localizes at nuclear speckles and interacts with a newly identified non-canonical poly(A) polymerase, which we have termed Star-PAP (nuclear speckle targeted PIPKIalpha regulated-poly(A) polymerase) and that the activity of Star-PAP can be specifically regulated by PtdIns4,5P2.