Serum proteomic analysis identifies sex-specific differences in lipid metabolism and inflammation profiles in adults diagnosed with Asperger syndrome.
Cambridge, United Kingdom. In Mol Autism, Dec 2013
Three of these proteins were altered in females (ADIPO, IgA, APOA1), seven were changed in males (BMP6, CTGF, ICAM1, IL-12p70, IL-16, TF, TNF-alpha) and six were changed in both sexes but in opposite directions (CHGA, EPO, IL-3, TENA, PAP, SHBG).
Molecular diagnosis of prostate cancer: are we up to age?
Philadelphia, United States. In Semin Oncol, Jun 2013
Historically used biomarkers such as prostatic acid phosphatase (PAP), serum prostate-specific antigen (PSA), and its precursor have not stood the challenge of sensitivity and specificity.
Emerging Roles of Human Prostatic Acid Phosphatase.
South Korea. In Biomol Ther (seoul), 2013
Prostatic acid phosphatase (PAP) is a non-specific phosphomonoesterase synthesized in prostate epithelial cells and its level proportionally increases with prostate cancer progression.
The novel poly(A) polymerase Star-PAP is a signal-regulated switch at the 3'-end of mRNAs.
Madison, United States. In Adv Biol Regul, 2013
We have discovered a novel nuclear poly(A) polymerase termed Star-PAP (nuclear speckle targeted PIPKIα regulated-poly(A) polymerase) that couples with the transcriptional machinery and is regulated by the phosphoinositide lipid messenger phosphatidylinositol-4,5-bisphosphate (PI4,5P(2)), the central lipid in phosphoinositide signaling.
A PtdIns4,5P2-regulated nuclear poly(A) polymerase controls expression of select mRNAs.
More papers using
Madison, United States. In Nature, 2008
Here we show that PIPKIalpha co-localizes at nuclear speckles and interacts with a newly identified non-canonical poly(A) polymerase, which we have termed Star-PAP (nuclear speckle targeted PIPKIalpha regulated-poly(A) polymerase) and that the activity of Star-PAP can be specifically regulated by PtdIns4,5P2.