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EGF containing fibulin-like extracellular matrix protein 1

S15, EFEMP1, fibulin-3
This gene encodes a member of the fibulin family of extracellular matrix glycoproteins. Like all members of this family, the encoded protein contains tandemly repeated epidermal growth factor-like repeats followed by a C-terminus fibulin-type domain. This gene is upregulated in malignant gliomas and may play a role in the aggressive nature of these tumors. Mutations in this gene are associated with Doyne honeycomb retinal dystrophy. Alternatively spliced transcript variants that encode the same protein have been described.[provided by RefSeq, Nov 2009] (from NCBI)
Top mentioned proteins: AGE, HAD, CAN, Epidermal Growth Factor, ACID
Papers using S15 antibodies
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
Yin Weilun et al., In BMC Plant Biology, 1975
... M: DL2000 marker, CK1: positive control, CK2: wild-type tobacco, S11-S15: transgenic tobacco of S1-GUS; S21-S25: ...
Papers on S15
Benzyl isothiocyanate alters the gene expression with cell cycle regulation and cell death in human brain glioblastoma GBM 8401 cells.
Chung et al., Laizhou, China. In Oncol Rep, Feb 2016
We also found that expression of 182 genes was downregulated and two genes were associated with receptor for cell responses to stimuli, the EGF containing fibulin-like extracellular matrix protein 1 (EFEMP1) was inhibited 2.01-fold and the TNF receptor-associated protein 1 (TRAP1) was inhibited 2.08-fold.
Identification of Genes Associated with Papillary Thyroid Carcinoma (PTC) for Diagnosis by Integrated Analysis.
Pang et al., Chongqing, China. In Horm Metab Res, Feb 2016
In the PPI network, MLLT1, DLG2, and EFEMP1 were the hub proteins, in which DLG2 and EFEMP1 were involved in tumor progression.
HMGB1 and its hyper-acetylated isoform are sensitive and specific serum biomarkers to detect asbestos exposure and to identify mesothelioma patients.
Yang et al., United States. In Clin Cancer Res, Feb 2016
Blood levels of previously proposed MM biomarkers fibulin-3, mesothelin, and osteopontin were also measured in non-healthy individuals.
Epidermal growth factor-containing fibulin-like extracellular matrix protein 1 (EFEMP1) expression and regulation in uterine leiomyoma.
Bulun et al., Chicago, United States. In Fertil Steril, Jan 2016
OBJECTIVE: To determine the presence, differential expression, and regulation of epidermal growth factor-containing fibulin-like extracellular matrix protein 1 (EFEMP1) in uterine leiomyomas.
Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference.
Shu et al., Nashville, United States. In Sci Rep, Dec 2015
We identified four novel loci near the EFEMP1, ADAMTSL3 , CNPY2, and GNAS genes that were associated with WC after adjustment for body mass index (BMI); two loci near the NID2 and HLA-DRB5 genes associated with WHR after adjustment for BMI, and three loci near the CEP120, TSC22D2, and SLC22A2 genes associated with WC without adjustment for BMI.
Comparison of mesothelin and fibulin-3 in pleural fluid and serum as markers in malignant mesothelioma.
Robinson et al., Perth, Australia. In Curr Opin Pulm Med, Jul 2015
One of the few new biomarkers to be identified through a biomarker discovery pipeline and evaluated in pleural effusions is fibulin-3.
The established and future biomarkers of malignant pleural mesothelioma.
Røe et al., Aalborg, Denmark. In Cancer Treat Rev, Jun 2015
Circulating proteomic and microRNA signatures, fibulin-3, tumor cell gene-ratio test, transcriptomic, lncRNA, glycopeptides, pleural fluid FISH assay, hyaluronate/N-ERC mesothelin and deformability cytometry may be important future markers.
Genome-wide association analysis identifies six new loci associated with forced vital capacity.
London et al., Rotterdam, Netherlands. In Nat Genet, 2014
We found six new regions associated at genome-wide significance (P < 5 × 10(-8)) with FVC in or near EFEMP1, BMP6, MIR129-2-HSD17B12, PRDM11, WWOX and KCNJ2.
Fibulin-4 and fibulin-5 in elastogenesis and beyond: Insights from mouse and human studies.
Yanagisawa et al., Dallas, United States. In Matrix Biol, 2014
The fibulin family of extracellular matrix/matricellular proteins is composed of long fibulins (fibulin-1, -2, -6) and short fibulins (fibulin-3, -4, -5, -7) and is involved in protein-protein interaction with the components of basement membrane and extracellular matrix proteins.
Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson's disease.
Dawson et al., Baltimore, United States. In Cell, 2014
Here, we show that ribosomal protein s15 is a key pathogenic LRRK2 substrate in Drosophila and human neuron PD models.
Age-related macular degeneration and changes in the extracellular matrix.
Romaniuk et al., Katowice, Poland. In Med Sci Monit, 2013
In the pathogenesis of AMD, a significant role is played by collagen type I and type IV; elastin; fibulin-3, -5, and -6; matrix metalloproteinase (MMP)-2, MMP-9, MMP-14, and MMP-1; and TIMP-3.
Fibulin-3 as a blood and effusion biomarker for pleural mesothelioma.
Goparaju et al., New York City, United States. In N Engl J Med, 2012
We investigated whether fibulin-3 in plasma and pleural effusions could meet sensitivity and specificity criteria for a robust biomarker.
Fibulin-3 promotes glioma growth and resistance through a novel paracrine regulation of Notch signaling.
Viapiano et al., Columbus, United States. In Cancer Res, 2012
Fibulin-3 promotes glioma growth and resistance through a novel paracrine regulation of Notch signaling.
Fibulin 3 peptides Fib3-1 and Fib3-2 are potential biomarkers of osteoarthritis.
Deberg et al., Liège, Belgium. In Arthritis Rheum, 2012
Our findings indicate that Fib3-1 and Fib3-2 are potential biochemical markers for the diagnosis of osteoarthritis
Compromised mutant EFEMP1 secretion associated with macular dystrophy remedied by proteostasis network alteration.
Kelly et al., Los Angeles, United States. In Mol Biol Cell, 2011
This study highlights the mechanisms underlying the inefficient secretion of R345W EFEMP1
Responsiveness of choroidal neovascular membranes in patients with R345W mutation in fibulin 3 (Doyne honeycomb retinal dystrophy) to anti-vascular endothelial growth factor therapy.
Tufail et al., Iowa City, United States. In Arch Ophthalmol, 2011
Choroid neovascularization in doyne honeycomb retinal dystrophy is sensitive to treatment with intravitreal bevacizumab, providing indirect evidence that vascular endothelial growth factor may play a role in this disease.
EFEMP1 suppresses malignant glioma growth and exerts its action within the tumor extracellular compartment.
Zhou et al., Irvine, United States. In Mol Cancer, 2010
EEFEMP1 suppresses glioma growth in vivo, both by modulating the tumor extracellular microenvironment and by altering critical intracellular oncogenic signaling pathways
Retinal ultrastructure of murine models of dry age-related macular degeneration (AMD).
Chan et al., Bethesda, United States. In Prog Retin Eye Res, 2010
First, genetically engineered mice that target genes related to juvenile macular dystrophies are the most common models, and they include abcr(-/-) (Stargardt disease), transgenic ELOVL4 (Stargardt-3 dominant inheritary disease), Efemp1(R345W/R345W) (Doyne honeycomb retinal dystrophy), and Timp3(S156C/S156C) (Sorsby fundus dystrophy) mice.
Genome-wide association analysis identifies 20 loci that influence adult height.
Frayling et al., Exeter, United Kingdom. In Nat Genet, 2008
The loci we identified implicate genes in Hedgehog signaling (IHH, HHIP, PTCH1), extracellular matrix (EFEMP1, ADAMTSL3, ACAN) and cancer (CDK6, HMGA2, DLEU7) pathways, and provide new insights into human growth and developmental processes.
A single EFEMP1 mutation associated with both Malattia Leventinese and Doyne honeycomb retinal dystrophy.
Schorderet et al., Iowa City, United States. In Nat Genet, 1999
Malattia Leventinese (ML) and Doyne honeycomb retinal dystrophy (DHRD) refer to two autosomal dominant diseases characterized by yellow-white deposits known as drusen that accumulate beneath the retinal pigment epithelium (RPE).
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