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EGF containing fibulin-like extracellular matrix protein 1

S15, EFEMP1, fibulin-3
This gene encodes a member of the fibulin family of extracellular matrix glycoproteins. Like all members of this family, the encoded protein contains tandemly repeated epidermal growth factor-like repeats followed by a C-terminus fibulin-type domain. This gene is upregulated in malignant gliomas and may play a role in the aggressive nature of these tumors. Mutations in this gene are associated with Doyne honeycomb retinal dystrophy. Alternatively spliced transcript variants that encode the same protein have been described.[provided by RefSeq, Nov 2009] (from NCBI)
Papers using S15 antibodies
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
Supplier
Yin Weilun et al., In BMC Plant Biology, 1975
... M: DL2000 marker, CK1: positive control, CK2: wild-type tobacco, S11-S15: transgenic tobacco of S1-GUS; S21-S25: ...
Papers on S15
Fibulin-3 promotes glioma growth and resistance through a novel paracrine regulation of Notch signaling.
GeneRIF
Viapiano et al., Columbus, United States. In Cancer Res, 2012
Fibulin-3 promotes glioma growth and resistance through a novel paracrine regulation of Notch signaling.
Fibulin 3 peptides Fib3-1 and Fib3-2 are potential biomarkers of osteoarthritis.
GeneRIF
Deberg et al., Li├Ęge, Belgium. In Arthritis Rheum, 2012
Our findings indicate that Fib3-1 and Fib3-2 are potential biochemical markers for the diagnosis of osteoarthritis
Compromised mutant EFEMP1 secretion associated with macular dystrophy remedied by proteostasis network alteration.
GeneRIF
Kelly et al., Los Angeles, United States. In Mol Biol Cell, 2011
This study highlights the mechanisms underlying the inefficient secretion of R345W EFEMP1
Responsiveness of choroidal neovascular membranes in patients with R345W mutation in fibulin 3 (Doyne honeycomb retinal dystrophy) to anti-vascular endothelial growth factor therapy.
GeneRIF
Tufail et al., Iowa City, United States. In Arch Ophthalmol, 2011
Choroid neovascularization in doyne honeycomb retinal dystrophy is sensitive to treatment with intravitreal bevacizumab, providing indirect evidence that vascular endothelial growth factor may play a role in this disease.
EFEMP1 suppresses malignant glioma growth and exerts its action within the tumor extracellular compartment.
GeneRIF
Zhou et al., Irvine, United States. In Mol Cancer, 2010
EEFEMP1 suppresses glioma growth in vivo, both by modulating the tumor extracellular microenvironment and by altering critical intracellular oncogenic signaling pathways
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