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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

S100 calcium binding protein A7

S100A7, Psoriasin, S100A15
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein differs from the other S100 proteins of known structure in its lack of calcium binding ability in one EF-hand at the N-terminus. This protein is markedly over-expressed in the skin lesions of psoriatic patients, but is excluded as a candidate gene for familial psoriasis susceptibility. The exact function of this protein is not known. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: S-100, CagA, Calgranulin B, CAN, Defensin
Papers using S100A7 antibodies
Papers on S100A7
Lipocalin-2 exacerbates psoriasiform skin inflammation by augmenting T-helper 17 response.
Watanabe et al., Tokyo, Japan. In J Dermatol, Jan 2016
Clinically, i.p. injected LCN2 exacerbated erythema and scaling in IMQ-treated murine skin compared with phosphate-buffered saline injection alone, and it augmented interleukin (IL)-17A, IL-17F, IL-22, IL-23p19, IL-12p40, CCL20, tumor necrosis factor-α, chemokine (C-X-C motif) ligand (CXCL)1, CXCL2, DEFB4, DEFB14, LCN2 and S100A7 mRNA levels of IMQ-treated murine skin while it did not increase the mRNA levels of interferon-γ, IL-12p35 or CXCL10.
Selection of specific interactors from phage display library based on sea lamprey variable lymphocyte receptor sequences.
Otlewski et al., Wrocław, Poland. In Biochim Biophys Acta, Dec 2015
We demonstrate general applicability of the scaffold by selecting dVLRs specific for lysozyme and S100A7 protein with KD values in the micromolar range.
Transcriptome profiling unveils the role of cholesterol in IL-17A signaling in psoriasis.
Saini et al., Delhi, India. In Sci Rep, Dec 2015
We found that accumulation of cholesterol was essential for IL-17A signaling as reduced total cholesterol levels by methyl β cyclodextrin (MBCD), significantly decreased IL-17A induced secretion of CCL20, IL-8 and S100A7 from the keratinocytes.
Evaluation and screening of mRNA S100A genes as serological biomarkers in different stages of bladder cancer in Egypt.
Abozeed et al., Cairo, Egypt. In Tumour Biol, Nov 2015
S100A7 can be used for the diagnosis of squamous cell carcinoma.
Disulphide-reduced psoriasin is a human apoptosis-inducing broad-spectrum fungicide.
Morita et al., Izumo, Japan. In Proc Natl Acad Sci U S A, Nov 2015
We purified Trichophyton rubrum-inhibiting activity from lesional psoriasis scale extracts and identified the Cys-reduced form of S100A7/psoriasin (redS100A7) as a principal antifungal factor.
Among the S100 proteins, S100A12 is the most significant marker for psoriasis disease activity.
Wenzel et al., Bonn, Germany. In J Eur Acad Dermatol Venereol, Oct 2015
OBJECTIVE: The aim of this study was to evaluate the impact of S100A7, S100A8, S100A9 and S100A12 as possible markers for disease activity in patients with psoriasis skin disease.
Up-Regulation of S100A11 in Lung Adenocarcinoma - Its Potential Relationship with Cancer Progression.
Masuda et al., Yokohama, Japan. In Plos One, 2014
The aim of the present study was to elucidate the potential molecular basis of these highly malignant lung tumors by focusing on S100 proteins (S100A2, S100A7, and S100A11), which are downstream targets of oncogenic KRAS and promoters of tumor progression.
Erratum to: Mechanistic attributes of S100A7 (psoriasin) in resistance of anoikis resulting tumor progression in squamous cell carcinoma of the oral cavity.
Mandal et al., Kharagpur, India. In Cancer Cell Int, 2014
[This corrects the article DOI: 10.1186/s12935-015-0226-9.].
Opposing Effects of Zac1 and Curcumin on AP-1-Regulated Expressions of S100A7.
Wang et al., Taipei, Taiwan. In Plos One, 2014
We demonstrated that mZac1 can enhance AP-1-responsive S100A7 expression of which the encoding gene was located in PSORS4 with HaCaT keratinocytes.
Joining S100 proteins and migration: for better or for worse, in sickness and in health.
Rudland et al., Birmingham, United Kingdom. In Cell Mol Life Sci, 2014
This review summarises some of the reported regulatory functions of S100 proteins (namely S100A1, S100A2, S100A4, S100A6, S100A7, S100A8/S100A9, S100A10, S100A11, S100A12, S100B and S100P) on cellular migration and invasion, established in both culture and animal model systems and the possible mechanisms that have been proposed to be responsible.
Psoriasin, a multifunctional player in different diseases.
Zheng et al., Xi'an, China. In Curr Protein Pept Sci, 2013
Psoriasin (S100A7) is one of the members in the S100 protein family.
Opposing functions of psoriasin (S100A7) and koebnerisin (S100A15) in epithelial carcinogenesis.
Wolf et al., München, Germany. In Curr Opin Pharmacol, 2013
Psoriasin (S100A7) and koebnerisin (S100A15) are highly homologous proteins that have been first described in psoriasis, which is characterized by disturbed epidermal maturation and chronic inflammation.
Psoriasin (S100A7) increases the expression of ROS and VEGF and acts through RAGE to promote endothelial cell proliferation.
Enerbäck et al., Göteborg, Sweden. In Breast Cancer Res Treat, 2012
psoriasin expression in mammary epithelial cells leads to increased endothelial cell proliferation in a paracrine manner through the receptor for advanced glycation end products.
S100A7 is present in human sperm and a homologous pig sperm protein interacts with sperm-binding glycoprotein (SBG).
Marini et al., Rosario, Argentina. In Andrologia, 2012
report the presence of S100A7 in human sperm and of a homologous protein in pig, with similar localisations
S100A7 enhances mammary tumorigenesis through upregulation of inflammatory pathways.
Ganju et al., Columbus, United States. In Cancer Res, 2012
Data show that hS100A7 and mS100a7a15 overexpression induce proliferation and expression of inflammatory cytokines/chemokines.
Tumor-suppressive effects of psoriasin (S100A7) are mediated through the β-catenin/T cell factor 4 protein pathway in estrogen receptor-positive breast cancer cells.
Ganju et al., Columbus, United States. In J Biol Chem, 2012
Tumor-suppressive effects of psoriasin (S100A7) are mediated through the beta-catenin/T cell factor 4 protein pathway in estrogen receptor-positive breast cancer cells.
Diminished levels of nasal S100A7 (psoriasin) in seasonal allergic rhinitis: an effect mediated by Th2 cytokines.
Cardell et al., Huddinge, Sweden. In Respir Res, 2011
The study showed an epithelial expression and excretion of S100A7 in the nose after microbial stimulation. The levels were diminished in rhinitis patients and in the presence of an allergic cytokine milieu.
Psoriasin: key molecule of the cutaneous barrier?
Harder et al., Kiel, Germany. In J Dtsch Dermatol Ges, 2011
Recent studies point to an important role of psoriasin as an antimicrobial and immunomodulatory protein in skin and other epithelia.
Novel S100A7 (psoriasin)/S100A15 (koebnerisin) subfamily: highly homologous but distinct in regulation and function.
Yuspa et al., Bethesda, United States. In Amino Acids, 2011
S100A7 (psoriasin) and S100A15 (koebnerisin) were first identified in inflamed psoriatic skin.
Antimicrobial psoriasin (S100A7) protects human skin from Escherichia coli infection.
Schröder et al., Kiel, Germany. In Nat Immunol, 2005
We show here that keratinocytes secrete, as the main E. coli-killing compound, the S100 protein psoriasin in vitro and in vivo in a site-dependent way.
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