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S100 calcium binding protein A2

S100A2, CaN19
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may have a tumor suppressor function. Chromosomal rearrangements and altered expression of this gene have been implicated in breast cancer. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: S-100, calcyclin, S100A4, p53, HAD
Papers on S100A2
Overexpression of the S100A2 protein as a prognostic marker for patients with stage II and III colorectal cancer.
New
Sugihara et al., Tokyo, Japan. In Int J Oncol, Feb 2016
Of these proteins, the S100 calcium-binding protein A2 (S100A2) has been observed in several human cancers.
Novel RNA variants in colorectal cancers.
New
Skotheim et al., Oslo, Norway. In Oncotarget, Dec 2015
These include a recurrent read-through fusion transcript between KLK8 and KLK7, and a splice variant of S100A2.
Diagnostic significance of S100A2 and S100A6 levels in sera of patients with non-small cell lung cancer.
New
Ren et al., Xi'an, China. In Tumour Biol, Oct 2015
Recent studies have demonstrated a link involving S100 Calcium Binding Proteins (S100A2, S100A6) and non-small cell lung cancer (NSCLC), but the expediency of their serum levels in NSCLC has not been established.
Carcinogenic nitrosamines in traditional beer as the cause of oesophageal squamous cell carcinoma in black South Africans.
New
Kumar et al., Johannesburg, South Africa. In S Afr Med J, Aug 2015
METHODS: Analysis by high-performance liquid chromatography was conducted for the identification of nitrosamines in traditional beer samples, and molecular docking studies were employed to predict the affinity between N-nitrosamines and the S100A2 protein.
Global analysis of chromosome 1 genes among patients with lung adenocarcinoma, squamous carcinoma, large-cell carcinoma, small-cell carcinoma, or non-cancer.
New
Wang et al., Shanghai, China. In Cancer Metastasis Rev, Jun 2015
CDC20, IL10, ECM1, GABPB2, CRABP2, and COL11A1 significantly predicted the poor overall survival of ADC patients and S100A2 and TIMM17A in SCC patients.
Comparative Proteomic Analysis of Human Cholangiocarcinoma Cell Lines: S100A2 as a Potential Candidate Protein Inducer of Invasion.
Komyod et al., Bangkok, Thailand. In Dis Markers, 2014
S100A2, a calcium-binding protein in S100 protein family, is upregulated in KKU-M213.
Use of proteins as biomarkers and their role in carcinogenesis.
Review
Zarogoulidis et al., Thessaloníki, Greece. In J Cancer, 2014
Other members of this family of proteins include S100A4, which has been associated with several malignancies and S100A2, which has been found to be decreased in some cancers.
Epigenetic silencing of S100A2 in bladder and head and neck cancers.
Moon et al., Baltimore, United States. In Oncoscience, 2014
S100A2, a member of the S100 protein family, is known to be downregulated in a number of human cancers, leading to its designation as a potential tumor suppressor gene.
Up-Regulation of S100A11 in Lung Adenocarcinoma - Its Potential Relationship with Cancer Progression.
Masuda et al., Yokohama, Japan. In Plos One, 2014
The aim of the present study was to elucidate the potential molecular basis of these highly malignant lung tumors by focusing on S100 proteins (S100A2, S100A7, and S100A11), which are downstream targets of oncogenic KRAS and promoters of tumor progression.
S100A2 protein and non-small cell lung cancer. The dual role concept.
Review
Kakolyris et al., Athens, Greece. In Tumour Biol, 2014
S100A2 is a member of the EF-hand motif family S100.
Joining S100 proteins and migration: for better or for worse, in sickness and in health.
Review
Rudland et al., Birmingham, United Kingdom. In Cell Mol Life Sci, 2014
This review summarises some of the reported regulatory functions of S100 proteins (namely S100A1, S100A2, S100A4, S100A6, S100A7, S100A8/S100A9, S100A10, S100A11, S100A12, S100B and S100P) on cellular migration and invasion, established in both culture and animal model systems and the possible mechanisms that have been proposed to be responsible.
S100 family signaling network and related proteins in pancreatic cancer (Review).
Review
Xiao et al., Nantong, China. In Int J Mol Med, 2014
Recently, S100A2 has been suggested to be a negative prognostic biomarker in pancreatic cancer, and the expression of S100A6 may be an independent prognostic impact factor.
Regulation of S100A2 expression by TGF-β-induced MEK/ERK signalling and its role in cell migration/invasion.
GeneRIF
Kondaiah et al., Bengaluru, India. In Biochem J, 2012
findings highlight an important link between the TGF-beta1-induced MAPK and p53 signalling pathways in the regulation of S100A2 expression and pro-tumorigenic actions
S100 proteins in cartilage: role in arthritis.
Review
Yammani, Winston-Salem, United States. In Biochim Biophys Acta, 2012
Several members of the S100 family (S100A1, S100A2, S100A4, S1008, S100A9, S100A11, and S100B) have been identified in human articular cartilage, and their expression is upregulated in diseased tissue.
Loss of Reprimo and S100A2 expression in human gastric adenocarcinoma.
GeneRIF
Liu et al., Wuhan, China. In Diagn Cytopathol, 2011
Loss of Reprimo and S100A2 expressions occurs frequently in gastric adenocarcinomas. The expressions of Reprimo and S100A2 may be potential biomarkers for gastric adenocarcinomas detection.
Lack of modulatory function of coding nucleotide polymorphism S100A2_185G>A in oral squamous cell carcinoma.
GeneRIF
Wu et al., T'ai-chung-shih, Taiwan. In Oral Dis, 2011
The coding sequence polymorphism S100A2_185G>A had no regulatory role in S100A2-mediated tumor suppression in oral cancer.
Identification of potential biomarkers for early and advanced gastric adenocarcinoma detection.
GeneRIF
Diaconu et al., Bucureşti, Romania. In Hepatogastroenterology, 2010
S100A2 is upregulated in gastric adenocarcinoma and is associated with tumor progression.
Crystallization and calcium/sulfur SAD phasing of the human EF-hand protein S100A2.
GeneRIF
Fritz et al., Konstanz, Germany. In Acta Crystallogr Sect F Struct Biol Cryst Commun, 2010
Although the diffraction data of S100A2 were recorded at a wavelength of 0.90 A, which is usually not assumed to be suitable for calcium/sulfur SAD, the anomalous signal was satisfactory.
Gene expression profiling of localized esophageal carcinomas: association with pathologic response to preoperative chemoradiation.
Impact
Ajani et al., Houston, United States. In J Clin Oncol, 2006
Using a combination marker approach, levels of PERP, S100A2, and SPRR3 allowed discrimination of pathCR from < pathCR with high sensitivity and specificity (85%).
Differential expression of S100A2 and S100A4 during progression of human prostate adenocarcinoma.
Impact
Mukhtar et al., Cleveland, United States. In J Clin Oncol, 2003
PURPOSE: To establish the clinical significance of calcium binding proteins S100A2 and S100A4 during progression of human prostate adenocarcinoma.
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