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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

L1 cell adhesion molecule

S10, Neural Cell Adhesion Molecule L1, L1CAM, MASA
The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause three X-linked neurological syndromes known by the acronym CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of a neuron-specific exon is thought to be functionally relevant. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, V1a, ACID, fibronectin
Papers using S10 antibodies
Negative regulation of primitive hematopoiesis by the FGF signaling pathway.
Supplier
Blagosklonny Mikhail, In PLoS ONE, 2005
... Anti- phospho-S10-H3 antibody was purchased from Upstate Cell Signaling (NY, #06-570), anti-GFP antibody ...
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.
Supplier
Faivre-sarrailh Catherine, In PLoS ONE, 1975
... Anti-L1CAM monoclonal antibody (ab24345) and anti-IgG polyclonal antibody (ab27478) were from Abcam.
Papers on S10
Generation, characterization and preclinical studies of a human anti-L1CAM monoclonal antibody that cross-reacts with rodent L1CAM.
New
Hong et al., Taejŏn, South Korea. In Mabs, Feb 2016
UNASSIGNED: L1 cell adhesion molecule (L1CAM) is aberrantly expressed in malignant tumors and plays important roles in tumor progression.
L1 cell adhesion molecule as a therapeutic target in cancer.
New
Jin et al., Shanghai, China. In Expert Rev Anticancer Ther, Feb 2016
UNASSIGNED: L1 cell adhesion molecule (L1CAM) is the prototype member of the L1-family of closely related neural adhesion molecules.
Prognostic significance of L1CAM expression and its association with mutant p53 expression in high-risk endometrial cancer.
New
Bosse et al., Leiden, Netherlands. In Mod Pathol, Feb 2016
UNASSIGNED: Studies in early-stage, predominantly low- and intermediate-risk endometrial cancer have demonstrated that L1 cell adhesion molecule (L1CAM) overexpression identifies patients at increased risk of recurrence, yet its prognostic significance in high-risk endometrial cancer is unclear.
Advances in the Understanding of the Pathogenesis of Inflammatory Acne.
New
Kircik, In J Drugs Dermatol, Feb 2016
</em>2016;15(1 Suppl 1):s7-s10.
Molecular targets and pathways involved in liver metastasis of colorectal cancer.
Review
New
Krüger et al., München, Germany. In Clin Exp Metastasis, Aug 2015
In addition, the functional role and validation of targets such as PRL3, Trop-2, L1CAM, S100A4, S100P, CD133, LIPC, and APOBEC3G are summarized.
L1CAM in human cancer.
Review
New
Fogel et al., Mannheim, Germany. In Int J Cancer, Jul 2015
UNASSIGNED: L1 cell adhesion molecule (L1CAM) is one of the first neural adhesion molecules described with important functions in the development of the nervous system.
Matrix interactions modulate neurotrophin-mediated neurite outgrowth and pathfinding.
Review
New
Heilshorn et al., Stanford, United States. In Neural Regen Res, Apr 2015
This synergism was mediated by Schwann cell-neurite contact through L1CAM.
The role of L1cam in murine corticogenesis, and the pathogenesis of hydrocephalus.
Review
New
Fushiki et al., Kyoto, Japan. In Pathol Int, Feb 2015
L1cam (L1), one of the cell adhesion molecules belonging to the immunoglobulin superfamily, plays critical roles in neuronal migration, axon growth, guidance, fasciculation, and synaptic plasticity in the central as well as the peripheral nervous system.
miR-503 inhibits cell proliferation and invasion in glioma by targeting L1CAM.
Yang et al., Changsha, China. In Int J Clin Exp Med, 2014
Furthermore, bioinformatics analysis indicated that L1CAM was a putative target of miR-503.
The ubiquitous neural cell adhesion molecule (N-CAM).
Review
Assob et al., Cameroon. In Ann Med Surg (lond), 2014
L1CAM and receptor tyrosine kinase.
Serpins promote cancer cell survival and vascular co-option in brain metastasis.
Impact
Massagué et al., New York City, United States. In Cell, 2014
Plasmin suppresses brain metastasis in two ways: by converting membrane-bound astrocytic FasL into a paracrine death signal for cancer cells, and by inactivating the axon pathfinding molecule L1CAM, which metastatic cells express for spreading along brain capillaries and for metastatic outgrowth.
An extracellular adhesion molecule complex patterns dendritic branching and morphogenesis.
Impact
Shen et al., Stanford, United States. In Cell, 2013
The ligand complex SAX-7/L1CAM and MNR-1 function at defined locations in the surrounding hypodermal tissue, whereas DMA-1 acts as the cognate receptor on PVD.
Skin-derived cues control arborization of sensory dendrites in Caenorhabditis elegans.
Impact
Bülow et al., United States. In Cell, 2013
We provide biochemical and genetic evidence that MNR-1 acts as a contact-dependent or short-range cue in concert with the neural cell adhesion molecule SAX-7/L1CAM in the skin and through the neuronal leucine-rich repeat transmembrane receptor DMA-1 on sensory dendrites.
Prognostic significance of L1CAM in ovarian cancer and its role in constitutive NF-κB activation.
GeneRIF
Altevogt et al., Heidelberg, Germany. In Ann Oncol, 2012
L1CAM expression and shedding in the tumor microenvironment could contribute to enhanced invasion and tumor progression through increased IL-1beta production and NF-kappaB activation.
Aberrant l1 cell adhesion molecule affects tumor behavior and chemosensitivity in anaplastic thyroid carcinoma.
GeneRIF
Shong et al., Taejŏn, South Korea. In Clin Cancer Res, 2012
L1CAM plays an important role in determining tumor behavior and chemosensitivity in cell lines derived from ATCs. Therefore
L1 cell adhesion molecule promotes tumorigenicity and metastatic potential in non-small cell lung cancer.
GeneRIF
Tsao et al., Toronto, Canada. In Clin Cancer Res, 2012
Data suggest that targeted inhibition of L1CAM may be a novel therapy for non-small cell lung cancer (NSCLC).
Myofibroblast-induced tumorigenicity of pancreatic ductal epithelial cells is L1CAM dependent.
GeneRIF
Sebens et al., Kiel, Germany. In Carcinogenesis, 2012
H6c7 cells exhibiting elevated L1CAM expression and epithelial-mesenchymal transition-associated alterations show a decreased apoptosis sensitivity toward death ligands
Autosomal recessive hereditary spastic paraplegia with thin corpus callosum among Saudis.
GeneRIF
Bohlega et al., Riyadh, Saudi Arabia. In Neurosciences (riyadh), 2012
Two novel mutations in SPG11 gene identified that confirmed link between SPG11 and autosomal recessive hereditary spastic paraplegia with thin corpus callosum.
Ankyrin-based subcellular gradient of neurofascin, an immunoglobulin family protein, directs GABAergic innervation at purkinje axon initial segment.
Impact
Huang et al., United States. In Cell, 2004
This synapse targeting process followed the establishment of a subcellular gradient of neurofascin186 (NF186), an L1 family immunoglobulin cell adhesion molecule (L1CAM), along the Purkinje AIS-soma axis.
Identification of potential anticancer drug targets through the selection of growth-inhibitory genetic suppressor elements.
Impact
Roninson et al., Chicago, United States. In Cancer Cell, 2003
Monoclonal antibodies against a cell surface protein identified by GSE selection, neural cell adhesion molecule L1CAM, strongly inhibited the growth of several tumor cell lines but not of untransformed cells.
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