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S100 calcium binding protein B

S-100, Nef, S100B
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, AGE, CD4, V1a
Papers using S-100 antibodies
Pseudo-merohedral twinning and noncrystallographic symmetry in orthorhombic crystals of SIVmac239 Nef core domain bound to different-length TCRζ fragments
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Stern Lawrence J. et al., In Acta Crystallographica Section D: Biological Crystallography, 2009
... Following cell lysis, the Nef fusion protein was isolated by Ni–NTA affinity chromatography (Qiagen) under denaturing conditions (8  ...
Cell death
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Shintaku Masayuki, In Virchows Archiv, 2008
... LC3 (polyclonal; Medical & Biological Laboratories, Nagoya, Japan; 1:1,000), CD68 (clone KP1, Dako; 1:100), and S-100 protein (clone ER-PR8, Dako; 1:500) ...
Quantifying the role of aberrant somatic hypermutation in transformation of follicular lymphoma
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Delabie Jan et al., In Journal of Hematopathology, 2007
... S-100 (polyclonal)DAKO Cytomation, Denmark A/S ...
Cell adhesion protein expression in melanocytic matricoma
Supplier
Burchette James L et al., In Rare Tumors, 2006
... IgG1, (Dako) used at 1:100; HMB- 45 mouse monoclonal IgG1 (Dako) used at 1:100, and S-100 rabbit polyclonal antibody (Dako, Carpinteria CA) used at ...
A case of primary small cell carcinoma of the breast
Supplier
Bergkvist Leif et al., In Pathology Research International, 2006
... clone CALP1, 1 : 600), p63 (Biocare Medical, clone BC4A4, 1 : 100), CD10 (Dako, clone 56C6, 1 : 50), and S-100 protein (Dako, clone ZO311, 1 : 3000) ...
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Papers on S-100
Migraine in patients with systemic lupus erythematosus is associated with reduced cerebral grey matter volume but not with measures of glial activation or anti-NR2 or anti-P antibodies.
New
Omdal et al., Stavanger, Norway. In Eur J Neurol, Feb 2016
Anti-NR2 and anti-P antibodies and protein S100B were measured in cerebrospinal fluid.
Potential Role of the Formation of Tunneling Nanotubes in HIV-1 Spread in Macrophages.
New
Suzu et al., Kumamoto, Japan. In J Immunol, Feb 2016
In this study, we show that HIV-1 promotes TNT formation per se via its protein Nef and a cellular protein M-Sec, which appears to mediate approximately half of viral spread among monocyte-derived macrophages (MDMs).
Vaccine Induction of Lymph Node-Resident Simian Immunodeficiency Virus Env-Specific T Follicular Helper Cells in Rhesus Macaques.
New
Robert-Guroff et al., Bethesda, United States. In J Immunol, Feb 2016
Macaques were primed twice mucosally with adenovirus 5 host range mutant recombinants encoding SIV Env, Rev, Gag, and Nef followed by two i.m. boosts with monomeric SIV gp120 or oligomeric SIV gp140 proteins.
Intracerebroventricular application of S100B selectively impairs pial arteriolar dilating function in rats.
New
Pelligrino et al., Chicago, United States. In Brain Res, Feb 2016
UNASSIGNED: S100B is an astrocyte-derived protein that can act through the receptor for advanced glycation endproducts (RAGE) to mediate either "trophic" or "toxic" responses.
Relative Resistance of HLA-B to Downregulation by Naturally Occurring HIV-1 Nef Sequences.
New
Ueno et al., Kumamoto, Japan. In Mbio, Dec 2015
UNLABELLED: HIV-1 Nef binds to the cytoplasmic region of HLA-A and HLA-B and downregulates these molecules from the surface of virus-infected cells, thus evading immune detection by CD8(+) T cells.
HIV-1 Nef hijacks clathrin coats by stabilizing AP-1:Arf1 polygons.
New
Impact
Hurley et al., Berkeley, United States. In Science, Nov 2015
The lentiviral Nef protein helps viruses evade innate and adaptive immune defenses by hijacking the adaptor protein 1 (AP-1) and AP-2 clathrin adaptors.
SERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by Nef.
New
Impact
Göttlinger et al., Worcester, United States. In Nature, Nov 2015
HIV-1 Nef and the unrelated mouse leukaemia virus glycosylated Gag (glycoGag) strongly enhance the infectivity of HIV-1 virions produced in certain cell types in a clathrin-dependent manner.
HIV-1 Nef promotes infection by excluding SERINC5 from virion incorporation.
New
Impact
Pizzato et al., Trento, Italy. In Nature, Nov 2015
HIV-1 Nef, a protein important for the development of AIDS, has well-characterized effects on host membrane trafficking and receptor downregulation.
Cerebral Toxocariasis: Silent Progression to Neurodegenerative Disorders?
Review
New
Barghouth et al., Taipei, Taiwan. In Clin Microbiol Rev, Jul 2015
Recent data describe an enhanced expression of biomarkers associated with brain injury, such as GFAP, AβPP, transforming growth factor β1 (TGF-β1), NF-L, S100B, tTG, and p-tau, in mice receiving even low doses of Toxocara ova.
Clinical Relevance of Kynurenine Pathway in HIV/AIDS: An Immune Checkpoint at the Crossroads of Metabolism and Inflammation.
Review
New
Jenabian et al., Montréal, Canada. In Aids Rev, Apr 2015
In addition to the activation of the kynurenine pathway by HIV proteins Tat and Nef, the tryptophan-degrading bacteria present in the intestinal flora have been associated with dysfunction of gut mucosal CD4 Th17/Th22 cells, leading to microbial translocation and creating a systemic kynurenine pathway activation cycle.
Antagonism of aminoacid transport in primary CD4 T cells by HIV-1 Vpu.
New
Impact
Lehner et al., Manchester, United Kingdom. In Lancet, Mar 2015
Novel substrates of the viral accessory proteins Vpu and Nef were sought by use of deletion viruses and single gene overexpression.
Biomarkers of Brain Damage and Postoperative Cognitive Disorders in Orthopedic Patients: An Update.
Review
Tomaszewski, Warsaw, Poland. In Biomed Res Int, 2014
In this review the short description of such biomarkers of brain damage as the S100B protein, NSE, GFAP, Tau protein, metalloproteinases, ubiquitin C terminal hydrolase, microtubule-associated protein, myelin basic protein, α-II spectrin breakdown products, and microRNA was made.
The role of molecular chaperones in clathrin mediated vesicular trafficking.
Review
Lafer et al., San Antonio, United States. In Front Mol Biosci, 2014
Association of clathrin with Hsc70 in vivo is regulated by Hsp110, an Hsp70 NEF that is itself a member of the Hsp70 family.
HIV-1 Infection of T Lymphocytes and Macrophages Affects Their Migration via Nef.
Review
Maridonneau-Parini et al., Toulouse, France. In Front Immunol, 2014
HIV-1-infected macrophages exhibit a reduced amoeboid migration but an enhanced mesenchymal migration, via the viral protein Nef.
Efficacy trial of a DNA/rAd5 HIV-1 preventive vaccine.
Impact
HVTN 505 Study Team et al., Aş Şanamayn, Syria. In N Engl J Med, 2013
The 6-plasmid DNA vaccine (expressing clade B Gag, Pol, and Nef and Env proteins from clades A, B, and C) was administered at weeks 0, 4, and 8.
Impact of frequent nocturnal hemodialysis on myocardial mechanics and cardiomyocyte gene expression.
GeneRIF
Rakowski et al., Toronto, Canada. In Circ Cardiovasc Imaging, 2012
Uremia clearance using NHD is accompanied by improvement in LV strain, rotation, reduction in mass and volume index. Dialysis downregulates genes for cardiomyocyte apoptosis and fibrosis and upregulates S100A1, which may improve LV contractility.
Calmodulin and S100A1 protein interact with N terminus of TRPM3 channel.
GeneRIF
Teisinger et al., Praha, Czech Republic. In J Biol Chem, 2012
Calmodulin and S100A1 protein interact with N terminus of TRPM3 channel.
[Jugular venous and arterial concentrations of serum S100B protein in patients with severe head injury].
GeneRIF
Sapin et al., Clermont-Ferrand, France. In Ann Biol Clin (paris), 2012
Determination of S100B concentration in jugular samples appears to be better than in arterial to predict clinical outcome after brain injury.
S100 proteins modulate protein phosphatase 5 function: a link between CA2+ signal transduction and protein dephosphorylation.
GeneRIF
Kobayashi et al., Japan. In J Biol Chem, 2012
S100A1 and permanently active S100P inhibited the apoptosis signal-regulating kinase 1 (ASK1) and PP5 interaction, resulting the inhibition of dephosphorylation of phospho-ASK1 by PP5
S100B serves as a Ca(2+) sensor for ROS-GC1 guanylate cyclase in cones but not in rods of the murine retina.
GeneRIF
Sharma et al., Boston, United States. In Cell Physiol Biochem, 2011
S100B is expressed in mouse photoreceptor cone outer segments but not in rods.
More papers using S-100 antibodies
Follicular dendritic cell sarcoma in the lymph nodes of the neck
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Adam Patrick et al., In Diagnostic Pathology, 2006
... S100DAKO ...
qBase relative quantification framework and software for management and automated analysis of real-time quantitative PCR data.
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Mallucci Giovanna R., In PLoS ONE, 2006
... protein zero () (1∶1000 in WB); polyclonal anti-glyceraldeyde 3 phosphate deydrogenase (I-19) (Santa Cruz, Biotechnology), a monoclonal anti-S100 antibody (Abcam), a monoclonal anti-myelin protein zero ...
Beta-catenin and E-cadherin expression in salivary gland tumors
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Manni J. J. et al., In European Archives of Oto-Rhino-Laryngology, 2005
... The immuno-histochemical panel contained antibodies against pankeratin (clone MNF116, 1:500, DAKO), S100 protein (1:5,000, DAKO) and Alfa smooth muscle ...
Activated AKT regulates NF-κB activation, p53 inhibition and cell survival in HTLV-1-transformed cells
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Simmet Thomas et al., In Journal of Biomedicine and Biotechnology, 2004
... Cruz, CA); actin-Chemicon International (Chemicon, Temecula, CA); HLA-DR, CD80, CD86, and CD1a-BD Biosciences (Heidelberg, Germany); S100 [28]-AbD SeroTec (Oxford, UK) ...
Tularemia in Denmark: identification of a Francisella tularensis subsp. holarctica strain by real-time PCR and high-resolution typing by multiple-locus variable-number tandem repeat analysis
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Wakasa Haruki et al., In Virchows Archiv, 2004
... Takeya, Kumamoto, Japan), Langerin (Novocastra Laboratories Ltd.), S-100 (Dako), D2-40 (Nichirei Corp.), Fascin, ...
Loss of keratin 10 is accompanied by increased sebocyte proliferation and differentiation
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Hummler Edith et al., In Nature Communications, 2003
... ) F4/80 and S100-positive cells in skin of 2-day-old transgenic and littermate controls ...
Serum S100B levels in patients with cerebral and extracerebral infectious disease
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Gonçalves Carlos-Alberto et al., In Journal of Neuroinflammation, 2003
... Polyclonal anti-S100B and anti-rabbit peroxidase linked were purchased from DAKO [São Paulo, Brazil] and ...
Comparative PRKAR1A genotype-phenotype analyses in humans with Carney complex and prkar1a haploinsufficient mice
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Blokx Willeke A. M. et al., In Acta Neuropathologica, 2003
... Slides were then incubated at room temperature with antibodies to S-100 protein (polyclonal, 1:800, Dako Co., Lot 00060051), Melan-A ...
Escherichia coli K-1 interaction with human brain micro-vascular endothelial cells triggers phospholipase C-gamma1 activation downstream of phosphatidylinositol 3-kinase.
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Jeyaseelan Samithamby, In PLoS ONE, 2002
... Biotechnology (Santa Cruz, CA); an anti-mouse CD146 Ab FITC-conjugated from Biolegend (San Diego, CA), a rabbit anti-S100B Ab from BD Biosciences, and a rabbit anti-CD54 Ab ...
hGFAP-cre transgenic mice for manipulation of glial and neuronal function in vivo
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Itohara Shigeyoshi et al., In Frontiers in Behavioral Neuroscience, 2000
... S100b-Cre transgenic mice ...
Cutting edgeidentification of GL50, a novel B7-like protein that functionally binds to ICOS receptor
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Moser Bernhard et al., In The Journal of Experimental Medicine, 1999
... (L26), CD21 (1F8), CD25 (ACT-1), and CD31 (JC/70A), rabbit IgG to CD3 (A0452), and bovine S-100 were from Dako; mouse antibodies to CCR3 (7B11) and CCR5 (5C7) were from LeukoSite, Inc.; and mouse antibody to HLA-DR (L243) was from Research Diagnostics Inc ...
Regulation of gene expression in vivo following transduction by two separate raav vectors
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Cucchiarini Magali et al., In Sarcoma, 1997
... the anti-Ki-67 (PP-67) and anti-SOX9 (C-20) antibodies from Santa Cruz Biotechnology (Heidelberg, Germany), and the anti-S-100 (Z0311) antibody from Dako Deutschland GmbH (Hamburg, Germany) ...
Viral dynamics in human immunodeficiency virus type 1 infection
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Koyanagi Yoshio et al., In Frontiers in Microbiology, 1994
... Cells were counted by staining them with an anti-SIV Nef monoclonal antibody (04–001, Santa Cruz Biotechnology, Santa Cruz, CA) labeled ...
Recurrent breakpoints at 9q31 and 22q12.2 in extraskeletal myxoid chondrsarcoma
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Mentzel Thomas et al., In Virchows Archiv, 1987
... S-100 proteinpolyclonal1:2000DAKO, Glostrup, Denmark ...
Studies on experimental malignant nerve sheath tumor maintained in tissue and organ culture system
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Rubin Brian P et al., In Rare Tumors, 1975
... paraffin-embedded tissue by the avidin-biotin-peroxidase complex technique using commercially available antibodies to the following antigens: S-100 (polyclonal; 1:8000; DAKO, Carpinteria, CA, USA), HMB-45/50 ...
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