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N-acetylneuraminic acid synthase

S as, sialic acid synthase
This gene encodes an enzyme that functions in the biosynthetic pathways of sialic acids. In vitro, the encoded protein uses N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN), respectively; however, it exhibits much higher activity toward the Neu5Ac phosphate product. In insect cells, expression of this gene results in Neu5Ac and KDN production. This gene is related to the E. coli sialic acid synthase gene neuB, and it can partially restore sialic acid synthase activity in an E. coli neuB-negative mutant. [provided by RefSeq, Jul 2008] (from NCBI)
Papers on S as
Identification of the nuclear export signals that regulate the intracellular localization of the mouse CMP-sialic acid synthetase.
Kitajima et al., Nagoya, Japan. In Biochem Biophys Res Commun, 2007
Intracellular localization of this enzyme is regulated not only due to the nuclear localization signal but also two nuclear export signals.
Solution structure of the antifreeze-like domain of human sialic acid synthase.
Hirota et al., Yokohama, Japan. In Protein Sci, 2006
The structure of the C-terminal antifreeze-like domain of human sialic acid synthase was determined. The structure comprises one alpha- and two single-turn 3(10)-helices and two beta-strands, and is similar to those of the type III antifreeze proteins.
Cloning, expression, and characterization of sialic acid synthases.
Sundaramoorthy et al., Nashville, United States. In Biochem Biophys Res Commun, 2006
sialic acid synthases kinetics and preliminary mutagenesis experiments reveal the importance of C-terminal antifreeze protein domain
Amplification of CDK4, MDM2, SAS and GLI genes in leiomyosarcoma, alveolar and embryonal rhabdomyosarcoma.
Benassi et al., Bologna, Italy. In Histol Histopathol, 2004
CDK4, MDM2, SAS and GLI genes are amplified in leiomyosarcoma, alveolar and embryonal rhabdomyosarcoma
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