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Nuclear receptor subfamily 1, group D, member 2

RVR, Rev-erbbeta, NR1D2
This gene encodes a member of the nuclear hormone receptor family, specifically the NR1 subfamily of receptors. The encoded protein functions as a transcriptional repressor and may play a role in circadian rhythms and carbohydrate and lipid metabolism. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009] (from NCBI)
Top mentioned proteins: HAD, Angiotensin II, Renin, CAN, ACID
Papers on RVR
A Mechanistic Model of the Intravitreal Pharmacokinetics of Large Molecules and the Pharmacodynamic Suppression of Ocular VEGF Levels by Ranibizumab in Patients with Neovascular Age-related Macular Degeneration.
Mazer et al., In Mol Pharm, Feb 2016
To understand the biophysical determinants of t1/2 for anti-VEGF antibodies and the time-course of VEGF in ocular fluids we developed a mechanistic model of intravitreal pharmacokinetics (IVT PK) for anti-VEGF antibodies and combined it with a mechanistic model of the pharmacodynamics (RVR PD) of VEGF suppression by ranibizumab, an anti-VEGF recombinant, humanized monoclonal antibody fragment (Fab).
Stabilization of Hypoxia-inducible Factor by DMOG Inhibits Development of Chronic Hypoxia-Induced Right Ventricular Remodeling.
Li et al., Beijing, China. In J Cardiovasc Pharmacol, Jan 2016
However, there is a paucity of data concerning right ventricular remodeling (RVR) in the setting of chronic hypoxia.
Comparison of three quantitative HCV RNA assays in samples from HCV genotype 1- or 4-infected patients treated with the NS3/4A protease inhibitor simeprevir.
Sarrazin et al., Beerse, Belgium. In J Clin Virol, Nov 2015
RESULTS: In GT1, of the 440 samples, 81% were undetectable (rapid virological response; RVR) by HPS at Week 4, 76% by CAP and 44% by ART.
Regulation of Renal Hemodynamics and Function by RGS2.
Blumer et al., Saint Louis, United States. In Plos One, 2014
RBF was reduced (35.4 ± 3.6 vs. 29.1 ± 2.1 μl/min/g body weight, p=0.08) while renal vascular resistance (RVR; 2.1 ± 0.2 vs. 3.0 ± 0.2 mmHg/μl/min/g body weight, p<0.01) was elevated in RGS2-/- compared to WT mice.
A Lead-In with Silibinin Prior to Triple-Therapy Translates into Favorable Treatment Outcomes in Difficult-To-Treat HIV/Hepatitis C Coinfected Patients.
Swiss HIV Cohort Study et al., Zürich, Switzerland. In Plos One, 2014
Six of the sixteen patients (37%) did not reach SVR 12: One patient had rapid virologic response (RVR) (i.e., undetectable HCV-RNA at week 4) but stopped treatment at week 8 due to major depression.
Performance and Value of IFN-Lambda3 and IFN-Lambda4 Genotyping in Patients with Chronic Hepatitis C (CHC) Genotype 2/3 in a Real World Setting.
Cornberg et al., Hannover, Germany. In Plos One, 2014
RESULTS: Both preferable IFNL3 genotypes were associated with RVR (both p<0.0001) rather than with SVR (rs12979860: p = 0.251; rs8099917: p = 0.447).
Role of Mas Receptor Antagonist A799 in Renal Blood Flow Response to Ang 1-7 after Bradykinin Administration in Ovariectomized Estradiol-Treated Rats.
Nematbakhsh et al., Eşfahān, Iran. In Adv Pharmacol Sci, 2014
Catheterized animals were subjected to BK and A799 infusion and mean arterial pressure (MAP), RBF, and renal vascular resistance (RVR) responses to Ang 1-7 (0, 100, and 300 ng kg(-1) min(-1)) were determined.
The Usefulness of Defining Rapid Virological Response by a Very Sensitive Assay (TMA) during Treatment of HCV Genotype 2/3 Infection.
Marcellin et al., Norway. In Plos One, 2014
Recruitment was from two trials comparing 14 and 24 weeks treatment to patients with rapid virological response (RVR) (n = 550).
Hepatitis C virus (HCV) genotype 2a has a better virologic response to antiviral therapy than HCV genotype 1b.
Li et al., Zhengzhou, China. In Int J Clin Exp Med, 2014
Patients with HCV genotype 2a had a significantly higher rapid virologic response (RVR), early virologic response, end-of-treatment response and SVR, and a lower relapse rate than patients with HCV genotype 1b.
24 versus 48 Weeks of Peginterferon Plus Ribavirin in Hepatitis C Virus Genotype 6 Chronically Infected Patients with a Rapid Virological Response: A Non-Inferiority Randomized Controlled Trial.
Gao et al., Guangzhou, China. In Plos One, 2014
Because of a high predictive value of rapid virological response (RVR) for sustained virological response (SVR), we conducted an open-label randomized controlled trial to compare 24- and 48-week peginterferon/ribavirin combination therapy for patients with HCV genotype 6 in Southern China who achieved an RVR.
[The value of genetics in the era of hepatitis C triple therapy].
Salmerón et al., Granada, Spain. In Gastroenterol Hepatol, 2014
Other baseline factors related to the host, the virus and, especially, to intratreatment factors such as rapid virological response (RVR) are strongly associated with the probability of achieving an SVR.
Functional vascular changes of the kidney during pregnancy in animals: a systematic review and meta-analysis.
Spaanderman et al., Netherlands. In Plos One, 2013
Renal vascular responses to pregnancy have frequently been studied, by investigating renal vascular resistance (RVR), renal flow, glomerular filtration rate (GFR), and renal artery responses to stimuli.
[Treatment guidelines for patients with genotype 1 chronic hepatitis C infection].
Kurelac et al., In Acta Med Croatica, 2013
In treatment-naïve patients with advanced fibrosis (F3 and F4) as well as in patients with moderate fibrosis (F2) and unfavorable predictors of treatment outcome (age > 40 years, non-CC IL-28B genotype, non-RVR), triple therapy is recommended.
Hepatitis C genotype 6: A concise review and response-guided therapy proposal.
Tanwandee et al., Bangkok, Thailand. In World J Hepatol, 2013
Emerging data suggests that a shorter course 24-wk treatment is equally effective as a standard 48-wk treatment, particularly for those patients who attained undetectable HCV RNA at week 4 (RVR).
Statin therapy improves response to interferon alfa and ribavirin in chronic hepatitis C: a systematic review and meta-analysis.
Liu et al., Xi'an, China. In Antiviral Res, 2013
Secondary outcome measures were rapid virological response (RVR) and early virological response (EVR).
Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β.
Evans et al., Los Angeles, United States. In Nature, 2012
data now unite REV-ERB-alpha and REV-ERB-beta with PER, CRY and other components of the principal feedback loop that drives circadian expression and indicate a more integral mechanism for the coordination of circadian rhythm and metabolism
Rev-erbα and Rev-erbβ coordinately protect the circadian clock and normal metabolic function.
Lazar et al., Philadelphia, United States. In Genes Dev, 2012
In mouse livers, Rev-erbbeta mRNA and protein levels oscillate with a diurnal pattern similar to that of Rev-erbalpha, and both Rev-erbs are recruited to a remarkably similar set of binding sites across the genome, enriched near metabolic genes
Thiol-disulfide redox dependence of heme binding and heme ligand switching in nuclear hormone receptor rev-erb{beta}.
Ragsdale et al., Ann Arbor, United States. In J Biol Chem, 2011
oxidative stress leads to oxidation of cysteine(s), thus releasing heme from Rev-erbbeta and altering its transcriptional activity.
Regulation of adipogenesis by natural and synthetic REV-ERB ligands.
Burris et al., Jupiter, United States. In Endocrinology, 2010
The results suggest that heme, functioning as a REV-ERB ligand, is an important signaling molecule for induction of adipogenesis. Synthetic small molecule ligands for REV-ERB are effective modulators of adipogenesis.
Nuclear receptor rev-erb-{alpha} circadian gene variants and lithium carbonate prophylaxis in bipolar affective disorder.
Collier et al., London, United Kingdom. In J Biol Rhythms, 2010
Nuclear receptor rev-erb-{alpha} circadian gene variants have a role in response to lithium carbonate in bipolar affective disorder
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