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Runt-related transcription factor 2

Runx2, Cbfa1, Core Binding Factor Alpha 1
This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Osteocalcin, CAN, C22, osteopontin, V1a
Papers using Runx2 antibodies
Age-related changes in the osteogenic differentiation potential of mouse bone marrow stromal cells.
Shi Songtao, In PLoS ONE, 2007
... SYBR Green PCR Master Mix (#4367659) from Applied Biosystems; Osx antibody (#ab22552) from Abcam Inc.; Runx2 (#130-3) monoclonal antibody from MBL International; Smurf1 (#AP2104a) and ...
CHIP promotes Runx2 degradation and negatively regulates osteoblast differentiation
Chang Zhijie et al., In The Journal of Cell Biology, 2003
... Anti–β-actin and anti-Runx2 (8G5) were purchased from Sigma-Aldrich and MBL International, respectively ...
Osteocyte dendrogenesis in static and dynamic bone formation: an ultrastructural study
De Pol A. et al., In European Journal of Histochemistry : EJH, 2003
... Rabbit anti-Runx2Abcam, Cambridge, UK ...
Cbfa1 contributes to the osteoblast-specific expression of type I collagen genes
Sun Xinhua et al., In International Journal of Molecular Sciences, 2000
... The anti-phospho-Runx2 antibody was purchased from Abcam Co (UK) ...
Regulation of E2F1 activity by acetylation.
Vanacker Jean-Marc, In PLoS ONE, 1999
... Polyclonal anti- Runx2 was purchased from Alpha Diagnostics Int ...
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Papers on Runx2
miR-33a-5p modulates TNF-α-inhibited osteogenic differentiation by targeting SATB2 expression in hBMSCs.
Huang et al., Shanghai, China. In Febs Lett, Feb 2016
Moreover, we show that BMP-2 induces SATB2 expression by interacting with SATB2 directly via the BMP-2-RUNX2 pathway.
EGCG ameliorates the hypoxia-induced apoptosis and osteogenic differentiation reduction of mesenchymal stem cells via upregulating miR-210.
Yang et al., Shenzhen, China. In Mol Biol Rep, Feb 2016
Results demonstrated that EGCG treatment significantly inhibited the hypoxia-induced apoptosis in MSCs and promoted the level of alkaline phosphatase (ALP), bone morphogenetic protein 2 (BMP-2), propeptide of type I procollagen I (PINP) and runt-related transcription factor 2 (RUNX2) in MSCs under either normoxia or hypoxia.
Tranilast stimulates endochondral ossification by upregulating SOX9 and RUNX2 promoters.
Ohno et al., Nagoya, Japan. In Biochem Biophys Res Commun, Feb 2016
It is strictly controlled by the expression of crucial transcriptional factors: SOX9 in the early phase and RUNX2 in the late phase.
Selective regulation of Mmp13 by 1,25(OH)2D3, PTH, and Osterix through distal enhancers.
Pike et al., Madison, United States. In J Steroid Biochem Mol Biol, Oct 2015
These activities occur through participation by the transcription factors VDR, RUNX2, FOS, JUN, and Osterix (OSX), respectively.
Glucose Uptake and Runx2 Synergize to Orchestrate Osteoblast Differentiation and Bone Formation.
Karsenty et al., New York City, United States. In Cell, Jul 2015
The synthesis of type I collagen, the main component of bone matrix, precedes the expression of Runx2, the earliest determinant of osteoblast differentiation.
Role of RUNX2 in Breast Carcinogenesis.
Pawlowska et al., Łódź, Poland. In Int J Mol Sci, 2014
RUNX2 is a transcription factor playing the major role in osteogenesis, but it can be involved in DNA damage response, which is crucial for cancer transformation.
Glucocorticoid-Induced Osteoporosis.
Tuckermann et al., Los Angeles, United States. In Adv Exp Med Biol, 2014
Future therapeutic approaches may aim at GC targets such as those mentioned above, or newly identified targets including the Notch pathway, the AP-1/Il11 axis and the osteoblast master regulator RUNX2.
RUNX2 and the PI3K/AKT axis reciprocal activation as a driving force for tumor progression.
Lasfar et al., New Brunswick, United States. In Mol Cancer, 2014
From the first reported role of the transcription factor RUNX2 in osteoblast and chondrocyte differentiation and migration to its involvement in promigratory/proinvasive behavior of breast, prostate, and thyroid cancer cells, osteosarcoma, or melanoma cells, RUNX2 currently emerges as a key player in metastasis.
Novel Implications of DNA Damage Response in Drug Resistance of Malignant Cancers Obtained from the Functional Interaction between p53 Family and RUNX2.
Shimozato et al., Chiba, Japan. In Biomolecules, 2014
Intriguingly, we have recently found that silencing ofpro-oncogenic RUNX2 enhances drug sensitivity of aggressive cancer cells regardless of p53status.
Expression of OPG, RANKL, and RUNX2 in rabbit periodontium under orthodontic force.
Zhang et al., Beijing, China. In Genet Mol Res, 2014
This study aims to investigate the expression changes of RANKL, RUNX2, and OPG in rabbit periodontal tissues under orthodontic force and explore its effect on the remodeling of periodontal tissues.
Genetic expression and functional characterization of the RUNX2 gene in human adult bone marrow mesenchymal stem cells.
Li et al., Shouguang, China. In Genet Mol Res, 2014
Past studies have revealed the critical role of runt-related transcription factor 2 (RUNX2) in the proliferation and differentiation of mesenchymal stem cells (MSCs).
Mechanical memory and dosing influence stem cell fate.
Anseth et al., Boulder, United States. In Nat Mater, 2014
We found that the activation of the Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding domain (TAZ) as well as the pre-osteogenic transcription factor RUNX2 in human mesenchymal stem cells (hMSCs) cultured on soft poly(ethylene glycol) (PEG) hydrogels (Young's modulus E ~ 2 kPa) depended on previous culture time on stiff tissue culture polystyrene (TCPS; E ~ 3 GPa).
Smooth muscle cell-specific runx2 deficiency inhibits vascular calcification.
Chen et al., Birmingham, United States. In Circ Res, 2012
We defined the functional role of smooth muscle cell-derived Runx2 in regulating vascular calcification and promoting infiltration of macrophages into the calcified lesion to form osteoclast-like cells.
Loss of RASSF1A synergizes with deregulated RUNX2 signaling in tumorigenesis.
O'Neill et al., Cambridge, United Kingdom. In Cancer Res, 2012
Loss of RASSF1A synergizes with deregulated RUNX2 signaling in tumorigenesis.
Transcription factor Runx2 is a regulator of epithelial-mesenchymal transition and invasion in thyroid carcinomas.
Katoh et al., Japan. In Lab Invest, 2012
Studied the potential molecular mechanism of thyroid cancer invasion.Data suggest enhanced Runx2 is functionally linked to tumor invasion and metastasis of thyroid carcinoma by regulating EMT-related molecules, MMPs and angiogenic/lymphangiogenic factors.
Control of mesenchymal lineage progression by microRNAs targeting skeletal gene regulators Trps1 and Runx2.
Stein et al., Worcester, United States. In J Biol Chem, 2012
analysis of control of mesenchymal lineage progression by microRNAs targeting skeletal gene regulators Trps1 and Runx2
Prevention of premature fusion of calvarial suture in GLI-Kruppel family member 3 (Gli3)-deficient mice by removing one allele of Runt-related transcription factor 2 (Runx2).
Rice et al., Helsinki, Finland. In J Biol Chem, 2012
a novel role for Gli3 in regulating calvarial suture development by controlling canonical Bmp-Smad signaling, which integrates a Dlx5/Runx2-II cascade
Building strong bones: molecular regulation of the osteoblast lineage.
Long, Saint Louis, United States. In Nat Rev Mol Cell Biol, 2012
In particular, all of the major developmental signals (including WNT and Notch signalling), along with an increasing number of transcription factors (such as RUNX2 and osterix), have been shown to regulate the differentiation and/or function of osteoblasts.
Modulating hedgehog signaling can attenuate the severity of osteoarthritis.
Alman et al., Toronto, Canada. In Nat Med, 2009
Furthermore, we show in mice and in human cartilage explants that pharmacological or genetic inhibition of Hh signaling reduces the severity of osteoarthritis and that runt-related transcription factor-2 (RUNX2) potentially mediates this process by regulating a disintegrin and metalloproteinase with thrombospondin type 1 motif-5 (ADAMTS5) expression.
Differential gene expression patterns and interaction networks in BCR-ABL-positive and -negative adult acute lymphoblastic leukemias.
Sikic et al., Stanford, United States. In J Clin Oncol, 2007
Finally, we constructed a gene expression- and interaction-based outcome predictor consisting of 27 genes (including GRB2, GAB1, GLI1, IRS1, RUNX2, and SPP1), which correlated with overall survival in BCR-ABL-positive adult ALL (P = .0001),
More papers using Runx2 antibodies
Overexpression of Cbfa1 in osteoblasts inhibits osteoblast maturation and causes osteopenia with multiple fractures
Komori Toshihisa et al., In The Journal of Cell Biology, 1986
... A DNA fragment covering the entire coding region of the mouse type II Cbfa1 isoform (Harada et al., 1999) was cloned into the mammalian expression vector pNASSβ (CLONTECH Laboratories, Inc.) by replacing ...
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