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RTF1 Rtf1p

Rtf1
This locus may represent a gene involved in regulation of transcription elongation and chromatin remodeling, based on studies of similar proteins in other organisms. The encoded protein may bind single-stranded DNA. [provided by RefSeq, Sep 2010] (from NCBI)
Top mentioned proteins: Paf1, POLYMERASE, Histone, FACT, Ctr9
Papers on Rtf1
The Double-Strand Break Landscape of Meiotic Chromosomes Is Shaped by the Paf1 Transcription Elongation Complex in Saccharomyces cerevisiae.
New
Shinohara et al., Ōsaka, Japan. In Genetics, Jan 2016
Given that RNA polymerase II associated factor 1 complex, Paf1C, promotes both types of methylation, we addressed the role of Paf1C component, Rtf1, in the regulation of meiotic DSB formation.
An RNAi-Based Candidate Screen for Modifiers of the CHD1 Chromatin Remodeler and Assembly Factor in Drosophila melanogaster.
New
Armstrong et al., Claremont, United States. In G3 (bethesda), Dec 2015
Our results indicate that CHD1 may act in opposition to other remodeling factors, including INO80, and that the recruitment of CHD1 to active genes by RTF1 is conserved in flies.
MEK1 is associated with carboplatin resistance and is a prognostic biomarker in epithelial ovarian cancer.
Győrffy et al., Budapest, Hungary. In Bmc Cancer, 2013
Based on the ROC analysis the eight most significant genes were JRK, CNOT8, RTF1, CCT3, NFAT2CIP, MEK1, FUBP1 and CSDE1.
Effects of cellular activation on anti-HIV-1 restriction factor expression profile in primary cells.
Pillai et al., San Francisco, United States. In J Virol, 2013
Expression of RTF1, RNA polymerase II-associated factor 1 (PAF1), TRIM11, TRIM26, and BST-2/tetherin correlated with decreased HIV-1 infectivity.
The Paf1 complex subunit Rtf1 buffers cells against the toxic effects of [PSI+] and defects in Rkr1-dependent protein quality control in Saccharomyces cerevisiae.
Arndt et al., Pittsburgh, United States. In Genetics, 2012
The Rtf1 subunit of the Paf1 complex is required for specific histone modifications, including histone H2B lysine 123 monoubiquitylation.
Small region of Rtf1 protein can substitute for complete Paf1 complex in facilitating global histone H2B ubiquitylation in yeast.
GeneRIF
Arndt et al., Pittsburgh, United States. In Proc Natl Acad Sci U S A, 2012
A histone modification domain (HMD), when expressed as the only source of Rtf1, can promote H3 K4 and K79 methylation and H2B K123 ubiquitylation in yeast.
Identification of a role for histone H2B ubiquitylation in noncoding RNA 3'-end formation through mutational analysis of Rtf1 in Saccharomyces cerevisiae.
GeneRIF
Arndt et al., Pittsburgh, United States. In Genetics, 2011
Results reveal functionally important residues in Rtf1, better define the roles of Rtf1 in transcription and histone modification.
The Paf1 complex represses ARG1 transcription in Saccharomyces cerevisiae by promoting histone modifications.
GeneRIF
Arndt et al., Pittsburgh, United States. In Eukaryot Cell, 2011
Rtf1-dependent histone2B ubiquitylation and histone3 Lys4 methylation repress ARG1 expression
Mass spectrometric studies on epigenetic interaction networks in cell differentiation.
Zhang et al., Riverside, United States. In J Biol Chem, 2011
Differential protein expression analysis established the networks linking histone hypoacetylation to the down-regulated expression/activity of p300 and linking histone H2B ubiquitination to the RNA polymerase II-associated FACT-RTF1-PAF1 complex.
Screening for microsatellite instability identifies frequent 3'-untranslated region mutation of the RB1-inducible coiled-coil 1 gene in colon tumors.
Mori et al., Baltimore, United States. In Plos One, 2008
3'UTR MSs demonstrated MSI frequencies in MSI-H tumors higher than the 99% upper limit predicted by MS length for RB1-inducible coiled-coil 1(RB1CC1, mutation frequency 68.4%), NUAK family SNF1-like kinase 1(NUAK1, 31.0%), and Rtf1, Paf1/RNA polymerase II complex component, homolog (RTF1, 25.0%).
Structure and DNA binding of the human Rtf1 Plus3 domain.
GeneRIF
Folkers et al., Utrecht, Netherlands. In Structure, 2008
Potential role of Rtf1 Plus single stranded DNA binding during transcription elongation.
Autoantigenic nuclear proteins of a clinically atypical renal vasculitis.
Martín-Vasallo et al., Santa Cruz de Tenerife, Spain. In J Autoimmune Dis, 2007
Clones Jos002 code for protein HDAC5, Jos014 for TFC4, Jos107 for RTF1, and Jos313 for POLDIP3 polymerase.
Rtf1 is a multifunctional component of the Paf1 complex that regulates gene expression by directing cotranscriptional histone modification.
GeneRIF
Arndt et al., Pittsburgh, United States. In Mol Cell Biol, 2007
Results indicate that Rtf1 influences transcription and chromatin structure through several independent functional domains and that Rtf1 may function independently of its association with other members of the Paf1 complex.
Paf1 complex homologues are required for Notch-regulated transcription during somite segmentation.
Takada et al., Okazaki, Japan. In Embo Rep, 2007
Members of the yeast polymerase-associated factor 1 (Paf1) complex, which is composed of at least five components (Paf1, Rtf1, Cdc73, Leo1 and Ctr9), are conserved from yeast to humans.
Generation and characterization of antibody against paf1 complex in Drosophila melanogaster.
Miao et al., Suzhou, China. In Sheng Li Xue Bao, 2007
We identified the Drosophila homological components of paf1, CDC73 and RTF1 of paf1 complex.
[Tolerance and efficacy of conformal radiotherapy for hepatocellular carcinoma in cirrhotic patients. Results of the French RTF1 phase II trial].
Trepo et al., Saint-Pierre-des-Corps, France. In Cancer Radiother, 2005
PURPOSE: While some patients presenting with hepatocellular carcinoma (HCC) benefit from curative therapies (transplantation, surgery, percutaneous ablation), others are only candidates for palliative options such as chemoembolization or symptomatic care.
Histone H3 lysine 4 mono-methylation does not require ubiquitination of histone H2B.
Géli et al., Marseille, France. In J Mol Biol, 2005
In contrast to Paf1 inactivation, deleting RTF1 affects H3K4 mono-methylation at the 3' coding region of active genes and results in a decrease of global H3K4 mono-methylation.
A Requirement for the Saccharomyces cerevisiae Paf1 complex in snoRNA 3' end formation.
Arndt et al., Pittsburgh, United States. In Mol Cell, 2005
To elucidate the functions of this complex, we isolated missense mutations in the gene encoding the Rtf1 subunit and used them to identify functionally interacting proteins.
Genetics of Ustilago maydis, a fungal pathogen that induces tumors in maize.
Review
Impact
Banuett, San Francisco, United States. In Annu Rev Genet, 1994
Several other genes have been identified (fuz1, fuz2, rtf1, uac, ubc) that affect different aspects of the life cycle transitions.
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