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RNA binding protein, fox-1 homolog

RTA
This gene is one of several human genes similar to the C. elegans gene Fox-1. This gene encodes an RNA binding protein that is thought to be a key regulator of alternative exon splicing in the nervous system and other cell types. The protein binds to a conserved UGCAUG element found downstream of many alternatively spliced exons and promotes inclusion of the alternative exon in mature transcripts. The protein also interacts with the estrogen receptor 1 transcription factor and regulates estrogen receptor 1 transcriptional activity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, Barr, HAD, ACID, V1a
Papers using RTA antibodies
Receptor affinity, stability and binding mode of Shiga toxins are determinants of toxicity.
Supplier
Cobine Paul, In PLoS ONE, 2006
... Ricin and RTA were purchased from Vector Laboratories (Burlingame, CA) ...
Activation of CD21 and CD23 gene expression by Kaposi's sarcoma-associated herpesvirus RTA.
Supplier
Gao Shou-Jiang, In PLoS Pathogens, 2004
... TIME cell lines expressing vIRF-1 or RTA in doxycycline (Dox)-inducible fashion were generated using the Retro-X Tet-On Advanced system (Clontech Laboratories; Mountainview, CA) ...
Chemical chaperones: a pharmacological strategy for disorders of protein folding and trafficking.
Supplier
Popoff Michel R., In PLoS ONE, 2001
... Ricin holotoxin, ricin B chain, and RTA were purchased from Vector Laboratories, Inc ...
Charting latency transcripts in Kaposi's sarcoma-associated herpesvirus by whole-genome real-time quantitative PCR.
Supplier
Sugden Bill, In PLoS Pathogens, 2001
... cells were grown in presence of hygromycin B (100 µg/ml) to maintain selection for the ORF50 (RTA) gene.The following antibodies were purchased from commercial suppliers: Cell Signaling Technologies [anti-p38 (Cat ...
Structure of ricin A-chain at 2.5 A. Proteins
Supplier
Popoff Michel R., In PLoS ONE, 1990
... agglutinin I (RCA-I), ricin toxin A subunit (RTA), and ricin toxin B subunit (RTB) were purchased from Vector Laboratories (Burlingame, CA) ...
Papers on RTA
Effects of ER stress on unfolded protein responses, cell survival, and viral replication in primary effusion lymphoma.
New
Fujimuro et al., Kyoto, Japan. In Biochem Biophys Res Commun, Feb 2016
In addition to the pro-apoptotic UPR, thapsigargin-induced ER stress enhanced transcription of lytic genes, including RTA, K-bZIP and K8.1, and viral production in PEL cells resulted in induction of the lytic cycle.
Engineering signaling aptamers that rely on kinetic rather than equilibrium competition.
New
Ellington et al., In Anal Chem, Feb 2016
Using an anti-ricin aptamer as a starting point, we developed a "competitive" aptasensor with a measured limit of detection (LOD) of 30 nM with an optical readout and as low as 3 nM for ricin toxin A-chain (RTA) detection on an electrochemical platform.
Histomorphological changes in testes of broad-snouted caimans (Caiman latirostris) associated with in ovo exposure to endocrine-disrupting chemicals.
New
Muñoz-de-Toro et al., Santa Fe de la Vera Cruz, Argentina. In J Exp Zool A Ecol Genet Physiol, Jan 2016
The relative seminiferous tubular area (RTA) was measured in testes and the proliferation index and the expression of estrogen receptor alpha (ERα) were quantified in intratubular cells.
The novel triterpenoid RTA 408 protects human retinal pigment epithelial cells against H2O2-induced cell injury via NF-E2-related factor 2 (Nrf2) activation.
New
Wu et al., Fort Worth, United States. In Redox Biol, Jan 2016
Previous studies have shown that RTA 408, a synthetic triterpenoid compound, potently activates Nrf2.
Comprehensive clinical approach to renal tubular acidosis.
Review
New
Saxena et al., New Delhi, India. In Clin Exp Nephrol, Aug 2015
Renal tubular acidosis (RTA) is essentially characterized by normal anion gap and hyperchloremic metabolic acidosis.
Maximizing the reactivity of phenolic and aminic radical-trapping antioxidants: just add nitrogen!
New
Impact
Pratt et al., Bologna, Italy. In Acc Chem Res, May 2015
Unprecedented reactivity was also observed when hydrocarbon autoxidations were carried out at elevated temperatures, real-world conditions where diarylamines are uniquely effective because of a catalytic RTA activity that makes use of the hydrocarbon substrate as a sacrificial reductant.
Highly efficient Cas9-mediated transcriptional programming.
New
Impact
Church et al., Cambridge, United States. In Nat Methods, Apr 2015
We describe an improved transcriptional regulator obtained through the rational design of a tripartite activator, VP64-p65-Rta (VPR), fused to nuclease-null Cas9.
Molecular biology of KSHV lytic reactivation.
Review
Verma et al., Reno, United States. In Viruses, 2015
Enhanced replication and transcription activator (RTA) gene expression triggers a cascade of events, resulting in the modulation of various cellular pathways to support viral DNA synthesis.
KSHV reactivation and novel implications of protein isomerization on lytic switch control.
Review
Lukac et al., Newark, United States. In Viruses, 2015
The KSHV Rta protein is the lytic switch for reactivation.
Ricin trafficking in cells.
Review
Lord et al., Coventry, United Kingdom. In Toxins (basel), 2015
Subsequently, the cell-binding B chain (RTB) and the catalytic A chain (RTA) are separated reductively, RTA embeds in the ER membrane and then retrotranslocates (or dislocates) across this membrane.
Epigenetic modification of Rta (ORF50) promoter is not responsible for distinct reactivation patterns of murine gammaherpesviruses.
Režuchová et al., In Acta Virol, 2014
Gammaherpesviruses-encoded replication and transcription activator (Rta) (ORF50) plays an essential role in the initiation of viral lytic gene expression and reactivation from latency.
Bardoxolone methyl (CDDO-Me) as a therapeutic agent: an update on its pharmacokinetic and pharmacodynamic properties.
Review
Zhou et al., Yinchuan, China. In Drug Des Devel Ther, 2013
Bardoxolone methyl, the C-28 methyl ester of 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid (CDDO) known as CDDO-Me or RTA 402, is one of the derivatives of synthetic triterpenoids.
RBFOX2 promotes protein 4.1R exon 16 selection via U1 snRNP recruitment.
GeneRIF
Benz et al., Boston, United States. In Mol Cell Biol, 2012
This study characterizes the mechanism by which RBFOX2 regulates protein 4.1R exon 16 splicing through the downstream intronic element UGCAUG.
FOX-2 dependent splicing of ataxin-2 transcript is affected by ataxin-1 overexpression.
GeneRIF
Krobitsch et al., Berlin, Germany. In Plos One, 2011
FOX-2 is involved in splicing of ataxin-2 transcripts and that this splicing event is altered by overexpression of ataxin-1
An EMT-driven alternative splicing program occurs in human breast cancer and modulates cellular phenotype.
GeneRIF
Gertler et al., Cambridge, United States. In Plos Genet, 2011
functional significance of EMT-associated alternative splicing depletion of RBFOX2 in mesenchymal cells
The ubiquitin E3 ligase RAUL negatively regulates type i interferon through ubiquitination of the transcription factors IRF7 and IRF3.
Impact
Hayward et al., Baltimore, United States. In Immunity, 2011
The Kaposi's sarcoma-associated herpes virus immediate-early lytic cycle trigger protein RTA recruited this mechanism to augment its countermeasures against the host antiviral response.
NeuN/Rbfox3 nuclear and cytoplasmic isoforms differentially regulate alternative splicing and nonsense-mediated decay of Rbfox2.
GeneRIF
Jensen et al., Adelaide, Australia. In Plos One, 2010
the negative regulation of Rbfox2 by Rbfox3 through a novel mechanism
Fox-2 protein regulates the alternative splicing of scleroderma-associated lysyl hydroxylase 2 messenger RNA.
GeneRIF
Yeowell et al., Durham, United States. In Arthritis Rheum, 2010
Fox-2 plays an integral role in the regulation of LH2 splicing and knockdown of Fox-2 may suggest a novel approach to strategies directed against scleroderma.
The KSHV immediate-early transcription factor RTA encodes ubiquitin E3 ligase activity that targets IRF7 for proteosome-mediated degradation.
Impact
Hayward et al., Baltimore, United States. In Immunity, 2005
Here, we report that interferon regulatory factor 7 (IRF7), a key mediator of type I IFN induction, is targeted for degradation by binding to the RTA immediate-early nuclear transcription factor encoded by Kaposi's sarcoma-associated herpesvirus (KSHV or HHV8).
Epidermal growth factor-toxin A chain conjugates: EGF-ricin A is a potent toxin while EGF-diphtheria fragment A is nontoxic.
Impact
Collier et al., In Cell, 1980
We have prepared a 2-pyridyl-dithiopropionate derivative of epidermal growth factor (EGF) and conjugated the derivative by disulfide interchange to the A chain of ricin (RTA) or to fragment A of diphtheria toxin (DTA).
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