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Ras suppressor protein 1

Rsu-1, RSP-1, Ras suppressor protein1
This gene encodes a protein that is involved in the Ras signal transduction pathway, growth inhibition, and nerve-growth factor induced differentiation processes, as determined in mouse and human cell line studies. In mouse, the encoded protein was initially isolated based on its ability to inhibit v-Ras transformation. Multiple alternatively spliced transcript variants for this gene have been reported; one of these variants was found only in glioma tumors. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Actin, integrin-linked kinase, ACID, AP-1, fibrillin-1
Papers on Rsu-1
Rsu1 regulates ethanol consumption in Drosophila and humans.
New
Rothenfluh et al., London, United Kingdom. In Proc Natl Acad Sci U S A, Aug 2015
Here, we report that Ras suppressor 1 (Rsu1) affects ethanol consumption in flies and humans.
Elimination of Ras Suppressor-1 from hepatocellular carcinoma cells hinders their in vitro metastatic properties.
New
Bogdanos et al., London, United Kingdom. In Anticancer Res, Mar 2015
Ras Suppressor-1 (RSU-1) is localized in the cell-ECM adhesions but its role in HCC is unexplored.
Ras suppressor-1 promotes apoptosis in breast cancer cells by inhibiting PINCH-1 and activating p53-upregulated-modulator of apoptosis (PUMA); verification from metastatic breast cancer human samples.
New
Gkretsi et al., Lárisa, Greece. In Clin Exp Metastasis, Mar 2015
Ras suppressor-1 (RSU-1) localizes to cell-ECM adhesions and binds to pro-survival adhesion protein PINCH-1.
Shift of the interconnection from the reaction system of paraoxonase 1 to the peroxidation reaction system of myeloperoxidase with HDL-C levels: a marker of atherosclerosis in patients with normal cholesterol levels.
Zheng et al., Changchun, China. In Clin Chim Acta, 2015
BACKGROUND: The interconnectivity of the peroxidation reaction system of myeloperoxidase (PRSM) or the reaction system of paraoxonase 1 (RSP1) with atherosclerosis remains elusive in patients with normal cholesterol levels.
Rsu1 contributes to cell adhesion and spreading in MCF10A cells via effects on P38 map kinase signaling.
Cutler et al., Bethesda, United States. In Cell Adh Migr, 2014
ILK also binds the adaptor protein PINCH which connects signaling proteins including Rsu1 to the complex.
Dissecting integrin-dependent regulation of neural stem cell proliferation in the adult brain.
Jessberger et al., Zürich, Switzerland. In J Neurosci, 2014
This effect downstream of ILK signaling is mediated through loss of Ras suppressor unit-1 (RSU-1), as virus-based reconstitution of RSU-1 expression rescued the ILK-dependent effects on NSPC proliferation.
Rsu1 contributes to regulation of cell adhesion and spreading by PINCH1-dependent and - independent mechanisms.
Cutler et al., Bethesda, United States. In J Cell Commun Signal, 2013
The signaling protein Rsu1 is linked to the complex via binding PINCH1.
Interactions by 2D Gel Electrophoresis Overlap (iGEO): a novel high fidelity approach to identify constituents of protein complexes.
Kadrmas et al., Salt Lake City, United States. In Proteome Sci, 2012
In Drosophila melanogaster, PINCH has two known high-affinity binding partners-Integrin-linked kinase (ILK) that binds to LIM1 and Ras Suppressor 1 (RSU1) that binds to LIM5-but has been postulated to bind additional proteins as well.
Promyelocytic leukemia (PML) protein plays important roles in regulating cell adhesion, morphology, proliferation and migration.
Lee et al., Hong Kong, Hong Kong. In Plos One, 2012
Nine proteins (PML, NDRG1, CACYBP, CFL1, RSU1, TRIO, CTRO, ANXA4 and UBE2M) were determined to be down-regulated in PML(-/-) MEFs.
PINCH-1 promotes Bcl-2-dependent survival signalling and inhibits JNK-mediated apoptosis in the primitive endoderm.
Fässler et al., Martinsried, Germany. In J Cell Sci, 2012
We report that loss of PINCH-1 in PrE cells leads to a sustained activity of JNK and the pro-apoptotic factor Bax. Mechanistically, the sustained JNK activation was due to diminished levels of the JNK inhibitory factor Ras suppressor protein-1 (RSU-1), whose stability was severely reduced upon loss of PINCH-1.
Strand-asymmetric endogenous Tetrahymena small RNA production requires a previously uncharacterized uridylyltransferase protein partner.
Collins et al., Berkeley, United States. In Rna, 2012
Here we characterize this 124-kDa protein, designated RNA silencing protein 1 (Rsp1), using endogenous locus tagging, affinity purification, and functional assays, as well as gene-knockout studies.
LRRC8 proteins share a common ancestor with pannexins, and may form hexameric channels involved in cell-cell communication.
Zardoya et al., Madrid, Spain. In Bioessays, 2012
We found that LRRC8 proteins originated from the combination of a pannexin and an LRR domain (most likely related to the SHOC2, LAP, RSU1 and LRRIQ4 protein families) before the diversification of chordates.
Altered expression of γ-secretase components in animal model of major depressive disorder induced by reserpine administration.
Hwang et al., Miryang, South Korea. In Lab Anim Res, 2012
Expression and phosphorylation of MKP-1, which is a key factor in MDD pathology, were both higher in the RSP2-treated group than the vehicle- and 1 mg/kg reserpine (RSP1)-treated groups (P<0.02).
The Rsu-1-PINCH1-ILK complex is regulated by Ras activation in tumor cells.
GeneRIF
Cutler et al., Italy. In Eur J Cell Biol, 2008
Rsu-1 links the Ras pathway with the IPP (integrin-linked kinase {ILK}, PINCH-1/LIMS1, parvin) complex and the perturbations of cell attachment-dependent signaling that occur in the malignant process
The Ras suppressor Rsu-1 binds to the LIM 5 domain of the adaptor protein PINCH1 and participates in adhesion-related functions.
GeneRIF
Cutler et al., Bethesda, United States. In Exp Cell Res, 2005
Rsu-1 interacts with the LIM 5 domain of PINCH1 in mammalian cells and functions, in part, by altering cell adhesion.
Identification of an alternatively spliced RNA for the Ras suppressor RSU-1 in human gliomas.
GeneRIF
Cutler et al., Bethesda, United States. In J Neurooncol, 2002
alternative splicing of exon 8 of the RSU-1 RNA to produce the exon-deleted form constitutes a mechanism for reduction or loss of functional Rsu-1. The exon-deleted form was not found in normal tissue.
Variations in chromosome size and organization in Candida albicans and Candida stellatoidea.
Review
Magee, Saint Paul, United States. In Trends Microbiol, 1993
These translocations seem to occur at hot spots characterized by the repeated DNA sequence RSP1.
Role of GTPases and GTPase regulatory proteins in oncogenesis.
Review
Maly et al., Innsbruck, Austria. In Crit Rev Oncog, 1992
Putative suppressor genes isolated from revertants from ras-transformed cells include rsp-1 and the ras recision gene (rrg).
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