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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

R-spondin 3

Rspo3, hPWTSR, cristin, R-spondin3, THSD2, thrombospondin type I domain containing 2
This gene encodes a member of the thrombospondin type 1 repeat supergene family. In addition, the protein contains a furin-like cysteine-rich region. Furin-like repeat domains have been found in a variety of eukaryotic proteins involved in the mechanism of signal transduction by receptor tyrosine kinases. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, CAN, Lgr5, thrombospondin-1, fibrillin-1
Papers on Rspo3
Targeting RSPO3 Reduces Stem Cell Function in PTPRK-RSPO3 Colon Tumors.
New
In Cancer Discov, Feb 2016
UNASSIGNED: Inhibition of RSPO3 induces differentiation of PTPRK-RSPO3 fusion-positive colon tumors.
Endothelial RSPO3 Controls Vascular Stability and Pruning through Non-canonical WNT/Ca(2+)/NFAT Signaling.
New
Augustin et al., Heidelberg, Germany. In Dev Cell, Feb 2016
The WNT signaling enhancer R-spondin3 (RSPO3) is prominently expressed in the vasculature.
Targeting PTPRK-RSPO3 colon tumours promotes differentiation and loss of stem-cell function.
New
Impact
de Sauvage et al., San Francisco, United States. In Nature, Feb 2016
Here we show that targeting RSPO3 in PTPRK-RSPO3-fusion-positive human tumour xenografts inhibits tumour growth and promotes differentiation.
RUNX1 and FOXP3 interplay regulates expression of breast cancer related genes.
New
Rubinstein et al., Buenos Aires, Argentina. In Oncotarget, Jan 2016
Furthermore we demonstrate that Runx1 is able to bind to R-spondin 3 (RSPO3) and Gap Junction protein Alpha 1 (GJA1) promoters.
Targeting the Wnt/β-catenin pathway in primary ovarian cancer with the porcupine inhibitor WNT974.
New
Buchsbaum et al., Birmingham, United States. In Lab Invest, Jan 2016
Expression of R-spondin 2 (RSPO2), RSPO3, PORCN, WLS, AXIN2, and three previously characterized RSPO fusion transcripts were assessed using Taqman assays.
The Angiocrine Factor Rspondin3 Is a Key Determinant of Liver Zonation.
New
Schedl et al., Nice, France. In Cell Rep, Jan 2016
Conditional deletion of Rspo3 in mice disrupts activation of central fate, demonstrating its crucial role in determining and maintaining β-catenin-dependent zonation.
Sequence variants in the PTCH1 gene associate with spine bone mineral density and osteoporotic fractures.
New
Stefansson et al., Reykjavík, Iceland. In Nat Commun, Dec 2015
We also identified a new spine BMD signal in RSPO3, rs577721086 (freq.
Wnt addiction of genetically defined cancers reversed by PORCN inhibition.
New
Virshup et al., Singapore, Singapore. In Oncogene, Sep 2015
Consistent with a central role of Wnt signaling in regulation of gene expression, inhibition of PORCN in RSPO3-translocated cancers causes a marked remodeling of the transcriptome, with loss of cell cycle, stem cell and proliferation genes, and an increase in differentiation markers.
Targeting Wnts at the source--new mechanisms, new biomarkers, new drugs.
Review
New
Virshup et al., Singapore, Singapore. In Mol Cancer Ther, May 2015
Loss-of-function mutations in RNF43 or ZNRF3 and gain-of-function chromosome translocations involving RSPO2 and RSPO3 are surprisingly common and markedly increase Wnt/β-catenin signaling in response to secreted Wnts.
The genetics of fat distribution.
Review
Kovacs et al., Leipzig, Germany. In Diabetologia, 2014
Moreover, recent GWAS identified several polymorphisms in developmental genes (including TBX15, HOXC13, RSPO3 and CPEB4) strongly associated with FD.
Clinical review: Genome-wide association studies of skeletal phenotypes: what we have learned and where we are headed.
Review
Kiel et al., Boston, United States. In J Clin Endocrinol Metab, 2012
Among 59 novel BMD GWAS loci that have not been reported by previous candidate gene association studies, some have been shown to be involved in key biological pathways involving the skeleton, particularly Wnt signaling (AXIN1, LRP5, CTNNB1, DKK1, FOXC2, HOXC6, LRP4, MEF2C, PTHLH, RSPO3, SFRP4, TGFBR3, WLS, WNT3, WNT4, WNT5B, WNT16), bone development: ossification (CLCN7, CSF1, MEF2C, MEPE, PKDCC, PTHLH, RUNX2, SOX6, SOX9, SPP1, SP7), mesenchymal-stem-cell differentiation (FAM3C, MEF2C, RUNX2, SOX4, SOX9, SP7), osteoclast differentiation (JAG1, RUNX2), and TGF-signaling (FOXL1, SPTBN1, TGFBR3).
Recurrent R-spondin fusions in colon cancer.
Impact
GeneRIF
de Sauvage et al., San Francisco, United States. In Nature, 2012
using RNA-seq data, identification of multiple fusion transcripts including recurrent gene fusions involving R-spondin family members RSPO2 and RSPO3 that together occur in 10% of colon tumours
Atlas of Wnt and R-spondin gene expression in the developing male mouse lower urogenital tract.
GeneRIF
Vezina et al., Madison, United States. In Dev Dyn, 2011
Sexually dimorphic expression patterns were observed for WNT/beta-catenin-responsive genes, and for Wnt2b, Wnt4, Wnt7a, Wnt9b, Wnt10b, Wnt11, Wnt16, and Rspo3 mRNAs.
Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits.
Impact
Cho et al., South Korea. In Nat Genet, 2011
(in C12orf51) for high-density lipoprotein cholesterol, 2p21 (near SIX2-SIX3) for fasting plasma glucose, 19q13.33 (in RPS11) and 6q22.33 (in RSPO3) for renal traits, and 12q24.11
Rspo3 binds syndecan 4 and induces Wnt/PCP signaling via clathrin-mediated endocytosis to promote morphogenesis.
GeneRIF
Niehrs et al., Heidelberg, Germany. In Dev Cell, 2011
Data show that Rspo3 binds syndecan 4 and that together they activate Wnt5a/PCP signaling.
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.
Impact
Lindgren et al., Regensburg, Germany. In Nat Genet, 2010
We identified 13 new loci in or near RSPO3, VEGFA, TBX15-WARS2, NFE2L3, GRB14, DNM3-PIGC, ITPR2-SSPN, LY86, HOXC13, ADAMTS9, ZNRF3-KREMEN1, NISCH-STAB1 and CPEB4 (P = 1.9 × 10⁻⁹ to P = 1.8 × 10⁻⁴⁰) and the known signal at LYPLAL1.
The Wnt signaling regulator R-spondin 3 promotes angioblast and vascular development.
GeneRIF
Niehrs et al., Heidelberg, Germany. In Development, 2008
identify Rspo3 as a novel, evolutionarily conserved angiogenic factor in embryogenesis
MMTV insertional mutagenesis identifies genes, gene families and pathways involved in mammary cancer.
Impact
Hilkens et al., Amsterdam, Netherlands. In Nat Genet, 2007
We validated one of these genes, Rspo3, as an oncogene by overexpression in a p53-deficient mammary epithelial cell line.
R-spondin3 is required for mouse placental development.
GeneRIF
Okamoto et al., Wako, Japan. In Dev Biol, 2007
suggest a critical role for Rspo3 in the interaction between chorion and allantois in labyrinthine development
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